INT67890

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Context Info
Confidence 0.67
First Reported 1997
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 26
Total Number 26
Disease Relevance 9.91
Pain Relevance 6.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SGCG) cytoskeleton (SGCG) cytoskeleton organization (SGCG)
cytoplasm (SGCG)
Anatomy Link Frequency
chondrocytes 2
nerve 2
HCT-15 2
epithelial cells 2
SGCG (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 13 100.00 Very High Very High Very High
analgesia 1 99.92 Very High Very High Very High
cINOD 4 99.56 Very High Very High Very High
Glutamate receptor 1 99.36 Very High Very High Very High
metalloproteinase 6 99.16 Very High Very High Very High
Pain 7 98.44 Very High Very High Very High
gABA 5 97.96 Very High Very High Very High
tetrodotoxin 8 97.40 Very High Very High Very High
peripheral neuropathy 6 97.10 Very High Very High Very High
agonist 7 94.92 High High
Disease Link Frequency Relevance Heat
Nociception 5 100.00 Very High Very High Very High
Pancreatic Cancer 10 99.84 Very High Very High Very High
Recurrence 5 99.60 Very High Very High Very High
Cancer 188 99.42 Very High Very High Very High
Breast Cancer 91 99.36 Very High Very High Very High
Disease 54 99.16 Very High Very High Very High
Tendinopathy 4 99.00 Very High Very High Very High
INFLAMMATION 9 98.84 Very High Very High Very High
Apoptosis 13 98.60 Very High Very High Very High
Pain 6 98.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blotting revealed that in hyperthermia there was initial release of Ca(2+) from the intracellular store site as indicated by increased expression of the type 1 inositol-1,4,5-trisphosphate receptor.
Positive_regulation (increased) of Gene_expression (expression) of type associated with fever
1) Confidence 0.67 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11861640 Disease Relevance 0.78 Pain Relevance 0.58
In degeneration, synthesis of matrix molecules changes, leading to an increase in the synthesis of collagens type I and III and a decreased production of aggrecan.
Positive_regulation (increase) of Gene_expression (synthesis) of type
2) Confidence 0.67 Published 2007 Journal Biochem. Soc. Trans. Section Abstract Doc Link 17635113 Disease Relevance 0.27 Pain Relevance 0.19
In animal models of CIPN, ALC administration promoted the recovery of nerve conduction velocity, restored the mechanical nociceptive threshold, and induced analgesia by up-regulating the expression of type-2 metabotropic glutamate receptors in dorsal root ganglia.
Positive_regulation (up-regulating) of Gene_expression (expression) of type in nerve associated with nociception, glutamate receptor, peripheral neuropathy and analgesia
3) Confidence 0.67 Published 2007 Journal CNS Drugs Section Abstract Doc Link 17696592 Disease Relevance 1.01 Pain Relevance 0.40
Growth factor treatment resulted in the following responses by the cells: (1) a higher mitogenic response than in the control cells; (2) a higher stimulation of type III collagen production and a lower stimulation of type I collagen production in CTS cells as compared with control cells; and (3) more alpha 2 (I) than alpha 1 (I) collagen production in CTS cells, unlike in control cells.
Positive_regulation (stimulation) of Gene_expression (production) of type
4) Confidence 0.67 Published 2000 Journal J. Occup. Environ. Med. Section Abstract Doc Link 10738704 Disease Relevance 0.24 Pain Relevance 0.24
However, overexpression of mam gene had statistically significant association with high grade (p = 0.0315) and showed a trend towards ER-negative tumors (22% vs. 11%) and a high risk category (15% vs. 6%; Table 3).
Positive_regulation (overexpression) of Gene_expression (overexpression) of mam associated with cancer
5) Confidence 0.58 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2292197 Disease Relevance 0.37 Pain Relevance 0
MUC1, a type I transmembrane mucin that can affect the adhesive properties of cells, contains a large extracellular tandem repeat domain, which is heavily glycosylated in normal epithelia, but is overexpressed and differentially glycosylated in pancreatic cancer.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of type associated with pancreatic cancer
6) Confidence 0.49 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17974963 Disease Relevance 0.73 Pain Relevance 0.10
Stable or transient expression of wild-type MC1R, but not of loss-of-function mutants, potently stimulates forskolin activation of adenylyl cyclase, a common feature of constitutively active Gs-coupled receptors.
Positive_regulation (stimulates) of Gene_expression (expression) of type associated with melanocortin 1 receptor
7) Confidence 0.49 Published 2004 Journal Pigment Cell Res. Section Abstract Doc Link 15250941 Disease Relevance 0.29 Pain Relevance 1.16
However, genistein-induced promoter activity was restored in HCT-15 cells by transfection with wild-type p53.
Positive_regulation (transfection) of Gene_expression (transfection) of type in HCT-15
8) Confidence 0.49 Published 2003 Journal Int. J. Cancer Section Abstract Doc Link 12767058 Disease Relevance 0.42 Pain Relevance 0.14
In breast carcinoma an increase in expression of peripheral-type benzodiazepine receptors (PBR) and the gamma aminobutyl acid (GABA) level has been discovered.
Positive_regulation (increase) of Gene_expression (expression) of type associated with gaba
9) Confidence 0.49 Published 2002 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 12139540 Disease Relevance 0.27 Pain Relevance 0.43
A 3.5-fold increase in type I collagen synthesis and a 7.5-fold increase in type III collagen synthesis of the affected areas was detected after 2 months of pimecrolimus treatment.
Positive_regulation (increase) of Gene_expression (synthesis) of type
10) Confidence 0.49 Published 2007 Journal Gynecol. Obstet. Invest. Section Body Doc Link 17085943 Disease Relevance 0.09 Pain Relevance 0
Growth factor treatment resulted in the following responses by the cells: (1) a higher mitogenic response than in the control cells; (2) a higher stimulation of type III collagen production and a lower stimulation of type I collagen production in CTS cells as compared with control cells; and (3) more alpha 2 (I) than alpha 1 (I) collagen production in CTS cells, unlike in control cells.
Positive_regulation (stimulation) of Gene_expression (production) of type
11) Confidence 0.49 Published 2000 Journal J. Occup. Environ. Med. Section Abstract Doc Link 10738704 Disease Relevance 0.24 Pain Relevance 0.24
Differential apoptosis by indomethacin in gastric epithelial cells through the constitutive expression of wild-type p53 and/or up-regulation of c-myc.
Positive_regulation (up-regulation) of Gene_expression (expression) of type in epithelial cells associated with apoptosis
12) Confidence 0.49 Published 1999 Journal Biochem. Pharmacol. Section Title Doc Link 10403534 Disease Relevance 0.91 Pain Relevance 0.20
Cloning of a new Kunitz-type protease inhibitor with a putative transmembrane domain overexpressed in pancreatic cancer.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of type associated with pancreatic cancer
13) Confidence 0.49 Published 1998 Journal Biochim. Biophys. Acta Section Title Doc Link 9434156 Disease Relevance 0.82 Pain Relevance 0.08
Interestingly, BDNF stimulation increased the expression of the pro-nociceptive genes cyclooxygenase-2, neurokinin-1 receptor, inositol trisphosphates receptor type 1, and BDNF itself, through both NFAT-dependent and NFAT-independent transcriptional mechanisms.
Positive_regulation (increased) of Gene_expression (expression) of type associated with nociception
14) Confidence 0.49 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17488277 Disease Relevance 0.61 Pain Relevance 0.52
Our recent studies show that alternative pre-mRNA splicing of a pair of 32 amino acid encoding exons in the C-terminus of Ca(V)2.2, e37a and e37b, underlie the expression of two mutually exclusive N-type channel isoforms.
Positive_regulation (underlie) of Gene_expression (expression) of type
15) Confidence 0.45 Published 2007 Journal Channels (Austin) Section Abstract Doc Link 18708749 Disease Relevance 0 Pain Relevance 0.37
A 3.5-fold increase in type I collagen synthesis and a 7.5-fold increase in type III collagen synthesis of the affected areas was detected after 2 months of pimecrolimus treatment.
Positive_regulation (increase) of Gene_expression (synthesis) of type
16) Confidence 0.45 Published 2007 Journal Gynecol. Obstet. Invest. Section Body Doc Link 17085943 Disease Relevance 0.08 Pain Relevance 0
In conclusion, NB69 cells displayed a slow, "TTX-resistant," or a fast, "TTX-sensitive" INa in DM and CM, respectively, suggesting that the CM contained diffusible trophic factors of astroglial origin that induced the expression of a different Na+ channel type.
Positive_regulation (induced) of Gene_expression (expression) of type associated with tetrodotoxin
17) Confidence 0.45 Published 1997 Journal Glia Section Abstract Doc Link 9034832 Disease Relevance 0.07 Pain Relevance 0.65
Eccentric rehabilitation exercise increases peritendinous type I collagen synthesis in humans with Achilles tendinosis.
Positive_regulation (increases) of Gene_expression (synthesis) of type associated with tendinopathy
18) Confidence 0.45 Published 2007 Journal Scand J Med Sci Sports Section Title Doc Link 16787448 Disease Relevance 0.45 Pain Relevance 0.10
Quantitative real-time polymerase chain reaction analyses showed that treatment with 5 ng/mL of PDGF-BB upregulated the mitochondrial RNA levels of type I and II collagens, MMPs, and TIMPs within 6 hours.
Positive_regulation (upregulated) of Gene_expression (levels) of type associated with metalloproteinase
19) Confidence 0.45 Published 2006 Journal Angle Orthod Section Abstract Doc Link 16637732 Disease Relevance 0.26 Pain Relevance 0.53
Ascorbic acid stimulates type I collagen production more in FR control than in FR-CTS.
Positive_regulation (stimulates) of Gene_expression (production) of type
20) Confidence 0.45 Published 2000 Journal J. Occup. Environ. Med. Section Abstract Doc Link 10738704 Disease Relevance 0.25 Pain Relevance 0.25

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