INT67895

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Context Info
Confidence 0.57
First Reported 1997
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 5.76
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IL1R1) plasma membrane (IL1R1) intracellular (IL1R1)
signal transducer activity (IL1R1)
Anatomy Link Frequency
endometrium 4
IL1R1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 102 99.28 Very High Very High Very High
antagonist 32 99.16 Very High Very High Very High
endometriosis 368 97.92 Very High Very High Very High
cytokine 52 97.16 Very High Very High Very High
Arthritis 4 78.40 Quite High
rheumatoid arthritis 12 74.48 Quite High
Angina 2 62.64 Quite High
Osteoarthritis 4 50.00 Quite Low
depression 4 35.76 Quite Low
anakinra 8 34.64 Quite Low
Disease Link Frequency Relevance Heat
Injury 10 99.84 Very High Very High Very High
Atherosclerosis 24 99.38 Very High Very High Very High
INFLAMMATION 112 99.28 Very High Very High Very High
Endometriosis 524 98.84 Very High Very High Very High
Arteritis 2 98.70 Very High Very High Very High
Apoptosis 28 97.88 Very High Very High Very High
Acute Coronary Syndrome 84 96.84 Very High Very High Very High
Stress 6 95.76 Very High Very High Very High
Disease 202 91.36 High High
Arthritis 8 78.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was a trend to decreased levels of IL-1ra in synovial membranes from patients with OA that did not attain statistical significance.
Negative_regulation (decreased) of IL-1ra
1) Confidence 0.57 Published 1997 Journal J. Rheumatol. Section Body Doc Link 9034998 Disease Relevance 0.10 Pain Relevance 0
Similarly, there was a decrease in the ratio of IL-1ra to IL-1 alpha and beta with increasing grades of OA.
Negative_regulation (decrease) of IL-1ra
2) Confidence 0.41 Published 1997 Journal J. Rheumatol. Section Body Doc Link 9034998 Disease Relevance 0 Pain Relevance 0
Overall, our preliminary data indicate that 1) IL-1 is a potent mediator of arterial inflammation in the context of atherosclerosis and vessel wall injury and 2) IL-1 inhibition restores endothelial function, reduces inflammatory vessel wall responses and reduces vascular oxidative stress.
Negative_regulation (inhibition) of IL-1 associated with stress, arteritis, inflammation, atherosclerosis and injury
3) Confidence 0.16 Published 2008 Journal Trials Section Body Doc Link PMC2289802 Disease Relevance 1.73 Pain Relevance 0.31
We believe our pre-clinical data indicates that a purely anti-inflammatory approach based upon Interleukin-1 (IL-1) inhibition using IL-1 receptor antagonist (IL-1ra) is a feasible and logical therapy for ACS and this approach could open a new therapeutic paradigm for evaluation in further studies.
Negative_regulation (inhibition) of IL-1 associated with acute coronary syndrome, inflammation and antagonist
4) Confidence 0.12 Published 2008 Journal Trials Section Body Doc Link PMC2289802 Disease Relevance 0.88 Pain Relevance 0.36
Reduction of IL-1R1 in the eutopic endometrium of baboons with induced endometriosis may increase the proliferative index of the endometrium; furthermore, aberration of ?
Negative_regulation (Reduction) of IL-1R1 in endometrium associated with endometriosis
5) Confidence 0.01 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775067 Disease Relevance 0.63 Pain Relevance 0.30
IL-1R1 mRNA levels were down-regulated 5-fold in eutopic endometriotic endometrium, while those of NFkB, eotaxin, and members of the activating protein-1 (AP-1) family, junD, c-fos and JNK2, were up-regulated 3.0-, 7.9-, 2.3-, and 1.8-fold, respectively [71].
Negative_regulation (down) of IL-1R1 in endometrium associated with endometriosis
6) Confidence 0.01 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775067 Disease Relevance 0.85 Pain Relevance 0.26
As described above, IL-1R1 was down-regulated in the eutopic endometrium of baboons experimentally induced with endometriosis [71].
Negative_regulation (down) of IL-1R1 in endometrium associated with endometriosis
7) Confidence 0.01 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775067 Disease Relevance 0.78 Pain Relevance 0.33
As described above, IL-1R1 was down-regulated in the eutopic endometrium of baboons experimentally induced with endometriosis [71].
Negative_regulation (regulated) of IL-1R1 in endometrium associated with endometriosis
8) Confidence 0.01 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775067 Disease Relevance 0.78 Pain Relevance 0.34

General Comments

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