INT679

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Context Info
Confidence 0.57
First Reported 1978
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 4.63
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CST3) extracellular region (CST3) endoplasmic reticulum (CST3)
lysosome (CST3) cytoplasm (CST3)
Anatomy Link Frequency
spinal cord 1
CST3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 1 99.68 Very High Very High Very High
Inflammation 1 98.24 Very High Very High Very High
Lasting pain 1 95.16 Very High Very High Very High
abdominal pain 1 93.52 High High
cINOD 3 91.80 High High
pain labor 1 84.48 Quite High
depression 1 77.28 Quite High
Sciatica 5 75.36 Quite High
Pain 13 75.00 Quite High
palliative 1 62.88 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 4 98.24 Very High Very High Very High
Lymphopenia 1 95.64 Very High Very High Very High
Pain 10 94.72 High High
Syndrome 9 93.68 High High
Abdominal Pain 1 93.52 High High
Leukocytosis 1 93.28 High High
Disease 2 91.92 High High
Cancer 1 91.92 High High
Necrosis 1 91.44 High High
Vomiting 2 90.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The result of ELISA experiment confirmed a considerable decrease in the level of cystatin C (p<0.01) in the patients with sciatica.
Negative_regulation (decrease) of cystatin C
1) Confidence 0.57 Published 2005 Journal Saudi Med J Section Body Doc Link 16311651 Disease Relevance 0.05 Pain Relevance 0
A recent subtractive cDNA cloning study in rats demonstrated an unexpected increase in expression of the proteinase inhibitor, cystatin C in the spinal cord during acute peripheral inflammation, suggesting this protein may be involved in the pathogenesis of persistent pain.
Negative_regulation (inhibitor) of cystatin C in spinal cord associated with pain, inflammation, lasting pain and spinal cord
2) Confidence 0.42 Published 2004 Journal Pain Section Abstract Doc Link 14736582 Disease Relevance 0.70 Pain Relevance 0.70
Improvement or preservation of stable renal function was observed in all patients--cystatin C levels decreased significantly from a mean 1.35 to 0.96 mg/l (p=0.007).
Negative_regulation (decreased) of cystatin C
3) Confidence 0.42 Published 2006 Journal Prz. Lek. Section Abstract Doc Link 16898486 Disease Relevance 0.89 Pain Relevance 0.09
There is an increase in the levels of lactoferrin, beta(2)-microglobulin, sodium, lysozyme C, and cystatin C, and a decrease in salivary amylase and carbonic anhydrase.
Negative_regulation (se in sa) of cystatin C
4) Confidence 0.42 Published 2008 Journal J. Dent. Res. Section Abstract Doc Link 18362310 Disease Relevance 1.79 Pain Relevance 0.06
Chymopapain was found to be inhibited efficiently by the protein inhibitors, cystatin C and low molecular weight kininogen in vitro, and the possible relevance of this finding to the efficacy and safety of chemonucleolysis is discussed.
Negative_regulation (inhibited) of cystatin C
5) Confidence 0.41 Published 1986 Journal Spine Section Abstract Doc Link 3787340 Disease Relevance 0.15 Pain Relevance 0.15
[Studies on D-penicillamine (1): Inhibitory effect of D-penicillamine on the heat-Cu++ induced denaturation of human gamma-globulin (author's transl)].
Negative_regulation (denaturation) of gamma-globulin
6) Confidence 0.37 Published 1978 Journal Nippon Yakurigaku Zasshi Section Title Doc Link 77827 Disease Relevance 0.09 Pain Relevance 0.09
Moreover, the calves treated with flumethasone exhibited a decrease in gamma-globulin concentration, and phagocytic parameters.
Negative_regulation (decrease) of gamma-globulin
7) Confidence 0.01 Published 2003 Journal Vet. Microbiol. Section Abstract Doc Link 14516708 Disease Relevance 0.94 Pain Relevance 0.11

General Comments

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