INT6791

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Context Info
Confidence 0.46
First Reported 1984
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 55
Total Number 57
Disease Relevance 5.36
Pain Relevance 17.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain 3
nerve 2
pyramidal cells 1
pore 1
skeletal muscle 1
NA (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 319 100.00 Very High Very High Very High
Nucleus accumbens 112 100.00 Very High Very High Very High
noradrenaline 50 100.00 Very High Very High Very High
antagonist 44 100.00 Very High Very High Very High
Hippocampus 39 100.00 Very High Very High Very High
Opioid 13 100.00 Very High Very High Very High
opiate 4 100.00 Very High Very High Very High
Clonidine 2 100.00 Very High Very High Very High
lidocaine 61 99.98 Very High Very High Very High
local anesthetic 47 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Influenza Virus Infection 86 100.00 Very High Very High Very High
Chronic Hepatitis 22 99.12 Very High Very High Very High
Hypoxia 15 98.76 Very High Very High Very High
Poisoning 29 97.56 Very High Very High Very High
Shellfish Poisoning 22 96.16 Very High Very High Very High
Overactive Bladder 5 95.76 Very High Very High Very High
Depression 88 91.04 High High
Helminth Infection 23 88.84 High High
Epilepsy 6 87.20 High High
INFLAMMATION 106 84.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using U-50,488H, a selective kappa-opioid agonist, we characterized the nature of interaction between opioids and the Na+/H+ antiporter.
Na Binding (interaction) of associated with mu agonist and opioid
1) Confidence 0.46 Published 1992 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 1333352 Disease Relevance 0 Pain Relevance 0.41
[Elementary properties and the interaction of single myocardial Na+ channels with antiarrhythmic drugs].
Na Binding (interaction) of
2) Confidence 0.40 Published 1989 Journal Arzneimittelforschung Section Title Doc Link 2541732 Disease Relevance 0 Pain Relevance 0.09
Using an analytical method based upon the Guarded Receptor Hypothesis, we calculated apparent rate constants describing lidocaine's interaction with the three primary states of the human Na+ channel (resting, activated and inactivated).
Na Binding (interaction) of associated with lidocaine
3) Confidence 0.39 Published 1995 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 7776390 Disease Relevance 0 Pain Relevance 0.48
The inhibitory effect of U-50,488H on Na+/H+ antiporter was immediate and reversible, and was not mediated through the interaction with the opioid receptors but due to the direct interaction of U-50,488H with the Na+/H+ antiporter.
Na Binding (interaction) of associated with opioid receptor
4) Confidence 0.34 Published 1992 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 1333352 Disease Relevance 0 Pain Relevance 0.41
These results differentiate loperamide from other Na+-H+ exchanger inhibitors such as amiloride, cimetidine and clonidine, which interact with the exchanger at a single site in a strictly competitive manner.
Na Binding (interact) of associated with clonidine
5) Confidence 0.33 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2822894 Disease Relevance 0 Pain Relevance 0.33
The transport process in SK-N-SH cells, monitored with deltorphin II as the substrate, is Na+/Cl--dependent and interacts with several opioid peptides, consisting of 5 to 13 amino acids.
Na Binding (interacts) of in SK-N-SH associated with opioid
6) Confidence 0.31 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17259448 Disease Relevance 0 Pain Relevance 0.46
At least some of the properties of local anesthetic interaction with the cardiac Na+ channels may be the result of kinetic effects mediated by binding to an external site.
Na Binding (interaction) of in external associated with local anesthetic
7) Confidence 0.30 Published 1991 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 1645415 Disease Relevance 0 Pain Relevance 0.39
METHODS: The binding of bupivacaine to Na+ channels was assessed indirectly by its antagonism of [3H]-batrachotoxin binding to rat brain synaptosomes.
Na Binding (binding) of in brain
8) Confidence 0.30 Published 2000 Journal Anesthesiology Section Body Doc Link 10969308 Disease Relevance 0 Pain Relevance 0
Experiments with recording the time of intraventricular reentry of the canine heart by a special protocol of stimulation showed that the first-line antiarrhythmic agents having various kinetics, ethacizine and lidocaine, compete for their binding to the Na+ channels of cardiac fibers.
Na Binding (binding) of in heart associated with antiarrhythmic agent and lidocaine
9) Confidence 0.30 Published 1990 Journal Kardiologiia Section Abstract Doc Link 2381129 Disease Relevance 0.07 Pain Relevance 0.30
We initially assumed that bupivacaine interacted only with the rested and inactivated states of the Na+ channel.
Na Binding (interacted) of
10) Confidence 0.30 Published 1995 Journal Circulation Section Body Doc Link 7586272 Disease Relevance 0 Pain Relevance 0
These results suggest that there may be diverse modes of interaction between the drug and the Na+ channel, and the combination of two different types of the drug may sometimes provide different effects on the fast and slow components of the use-dependent block of Vmax.
Na Binding (interaction) of
11) Confidence 0.30 Published 1991 Journal Cardiovasc Drugs Ther Section Abstract Doc Link 1931756 Disease Relevance 0 Pain Relevance 0.50
The affinity of the alpha2-antagonist for the receptor was enhanced by Na+ but not by guanine nucleotide, suggesting that the binding of the antagonist is modulated only by Na+.
Na Binding (binding) of associated with antagonist
12) Confidence 0.29 Published 1985 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2865159 Disease Relevance 0 Pain Relevance 0.27
These data suggest that lidocaine binds to both the activated and inactivated states of the human cardiac Na+ channel.
Na Binding (binds) of associated with lidocaine
13) Confidence 0.29 Published 1995 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 7776390 Disease Relevance 0 Pain Relevance 0.46
The suitability of these cells for automated patch clamp suggests they may be useful for higher throughput studies of the interaction of drugs with human skeletal muscle Na+ channels.
Na Binding (interaction) of in skeletal muscle
14) Confidence 0.28 Published 2006 Journal Pharmacol. Res. Section Abstract Doc Link 16675265 Disease Relevance 0.07 Pain Relevance 0.23
The Na(+)-channel binding neurotoxin brevetoxin showed high-affinity specific binding in both turtle and rat synaptosomes, suggesting specific ligand-receptor interaction.
Na Binding (binding) of
15) Confidence 0.27 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2481405 Disease Relevance 0.10 Pain Relevance 0
Binding of tetrodotoxin and saxitoxin to Na+ channels at different holding potentials: fluctuation measurements in frog myelinated nerve.
Na Binding (Binding) of in nerve associated with tetrodotoxin
16) Confidence 0.24 Published 1989 Journal Biochim. Biophys. Acta Section Title Doc Link 2553116 Disease Relevance 0 Pain Relevance 0.55
The 12S component appears to carry the site that binds opiates in the absence of Na+ ions while the 10S component would carry the other site, i.e. the one which is seen only in the presence of Na+ ions in equilibrium binding studies.
Na Binding (binds) of associated with opiate
17) Confidence 0.24 Published 1984 Journal Neuropeptides Section Abstract Doc Link 6099480 Disease Relevance 0 Pain Relevance 0.37
Studies on firing properties of sensory neurons of dorsal root ganglia demonstrate that the effects of gain-of-function mutations in Na(v)1.7 on the excitability of these neurons depend on the presence of Na(v)1.8, which suggests a similar physiological interaction of these two channels in humans carrying the Na(v)1.7 pain mutation.
Na Binding (interaction) of in dorsal root ganglia
18) Confidence 0.23 Published 2009 Journal Pain Med Section Body Doc Link 19818036 Disease Relevance 0 Pain Relevance 0
We tested several compounds, including hormonal steroids, bile salts, lipids, and methionine-enkephalin, for their ability to cross-react with two commercially available 125I digoxin RIAs, to inhibit porcine Na+K+ATPase, and to see whether they present the same incubation temperature dependence as human cord serum.
Na Spec (whether) Binding (cross-react) of in bile associated with addiction, bile and enkephalin
19) Confidence 0.23 Published 1991 Journal Clin. Chem. Section Abstract Doc Link 1718632 Disease Relevance 0 Pain Relevance 0.32
Using DNA primers designed to bind to the rat brain IIA Na+ channel subtype, we amplified specific polymerase chain reaction (PCR) fragments from CHO-K1 poly-(A)+RNA.
Na Binding (bind) of in brain
20) Confidence 0.16 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 7682773 Disease Relevance 0 Pain Relevance 0.33

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