INT67912

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Context Info
Confidence 0.77
First Reported 1997
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 75
Total Number 81
Disease Relevance 28.99
Pain Relevance 29.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GRIN1)
Anatomy Link Frequency
oocytes 6
embryonic kidney 5
neocortex 4
synapses 3
forebrain 2
GRIN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 666 100.00 Very High Very High Very High
nMDA receptor 492 100.00 Very High Very High Very High
antagonist 176 100.00 Very High Very High Very High
Glutamate receptor 125 100.00 Very High Very High Very High
GABA receptor 9 100.00 Very High Very High Very High
excitatory amino acid 5 100.00 Very High Very High Very High
Cannabinoid receptor 4 100.00 Very High Very High Very High
intrathecal 121 99.98 Very High Very High Very High
Inflammation 159 99.88 Very High Very High Very High
agonist 120 99.58 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 176 99.88 Very High Very High Very High
Ovarian Cancer 68 99.68 Very High Very High Very High
Autism 2664 99.64 Very High Very High Very High
Death 81 99.64 Very High Very High Very High
Sclerosis 52 99.64 Very High Very High Very High
Targeted Disruption 294 99.22 Very High Very High Very High
Dyspepsia 41 99.08 Very High Very High Very High
Limbic Encephalitis 51 99.00 Very High Very High Very High
Alcohol Addiction 97 98.92 Very High Very High Very High
Ganglion Cysts 70 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since most biotransformation processes in the liver are under the control of nuclear receptors (NR), treatment modalities aiming to stimulate or inhibit NR expression are at present tested in animal models of APAP toxicity or cholestasis.
Gene_expression (expression) of NR in liver associated with toxicity and gallstones
1) Confidence 0.77 Published 2007 Journal Mol. Pharm. Section Abstract Doc Link 18001054 Disease Relevance 0.78 Pain Relevance 0.09
In an attempt to identify more potent 18-methoxycoronaridine analogs, we have tested a series of 18-methoxycoronaridine congeners by whole-cell patch clamp recording of HEK 293 cells expressing recombinant nicotinic alpha3beta4 receptors or glutamate NR1/NR2B N-methyl-d-aspartate (NMDA) receptors.
Gene_expression (expressing) of NR1 associated with glutamate
2) Confidence 0.75 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15178360 Disease Relevance 0 Pain Relevance 0.24
We tested the effects of tramadol and its M1 metabolite (0.1-100 microM) on human recombinant neurotransmitter-gated ion channels, including glycine, gamma-aminobutyric acid(A) (GABA(A)), and N-methyl-D-aspartate (NMDA) receptors, expressed in Xenopus oocytes.
Gene_expression (expressed) of NMDA in oocytes associated with tramadol, gaba and neurotransmitter
3) Confidence 0.75 Published 2005 Journal Anesth. Analg. Section Abstract Doc Link 15845694 Disease Relevance 0 Pain Relevance 1.26
Differential binding properties of [3H]dextrorphan and [3H]MK-801 in heterologously expressed NMDA receptors.
Gene_expression (expressed) of NMDA associated with nmda receptor
4) Confidence 0.75 Published 2005 Journal Neuropharmacology Section Title Doc Link 15992576 Disease Relevance 0 Pain Relevance 0.49
Platelets have been considered as a suitable model for studying glutamatergic dysfunction because they perform glutamate uptake and express both external transporters, and NMDA-like receptors.
Gene_expression (express) of NMDA in external associated with glutamate
5) Confidence 0.75 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16814469 Disease Relevance 0 Pain Relevance 0.35
METHODS: alpha1beta2gamma2sgamma-aminobutyric acid type A (GABA(A)), alpha1 glycine, NR1/NR2A N-methyl-d-aspartate, and two pore domain TRESK channels were expressed in Xenopus laevis oocytes and studied using two-electrode voltage clamping.
Gene_expression (expressed) of NR1 in oocytes
6) Confidence 0.75 Published 2007 Journal Anesth. Analg. Section Body Doc Link 17717222 Disease Relevance 0 Pain Relevance 0
In mice genetically modified to over express NMDA NR2B receptors in forebrain areas, including the ACC, behavioral responses to tissue inflammation were significantly enhanced [29].
Gene_expression (express) of NMDA in forebrain associated with inflammation and anterior cingulate cortex
7) Confidence 0.75 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074356 Disease Relevance 0.77 Pain Relevance 0.83
To determine whether there was an overall decrease in cell surface expression of NR2A-containing NMDARs in Neto1-null mice, we quantified the abundance of biotinylated cell surface proteins in wild-type and Neto1-null hippocampal slices.
Gene_expression (expression) of NMDA
8) Confidence 0.75 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.07
No differences in the level of biotinylated NR1, NR2A, or NR2B were found in Neto1-null compared with wild-type mice (Figure S4A), indicating that the overall cell surface expression of NMDARs is normal in the hippocampus in the absence of Neto1.
Gene_expression (expression) of NMDA in hippocampus associated with hippocampus
9) Confidence 0.75 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0.09
After persistent inflammation, the expression of NMDA NR2B receptors in the ACC was up-regulated with the enhanced behavioral responses [44], consistent with the increased inflammation-related persistent pain in NR2B forebrain overexpression mice [7].
Gene_expression (expression) of NMDA in forebrain associated with pain, inflammation, lasting pain and anterior cingulate cortex
10) Confidence 0.75 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734546 Disease Relevance 1.22 Pain Relevance 1.31
To verify that the NMDA receptors expressed also pass Ca2+ we performed Fluo-3 Ca2+ imaging.
Gene_expression (expressed) of NMDA associated with nmda receptor and imagery
11) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2752165 Disease Relevance 0 Pain Relevance 0.35
Because patients are usually exposed concomitantly to volatile anesthetics, we tested the hypothesis that volatile anesthetics interact with ketamine and/or Mg2+ at recombinantly expressed NMDA receptors.
Gene_expression (expressed) of NMDA associated with ketamine and nmda receptor
12) Confidence 0.75 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11323344 Disease Relevance 0 Pain Relevance 0.38
It is quite likely, however, that the increased expression of NMDA receptor genes, especially Grin2b, was a reflection of the growth of new synapses [39].
Gene_expression (expression) of NMDA in synapses associated with nmda receptor
13) Confidence 0.75 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.39 Pain Relevance 0.29
NR1/NR2A or NR1/NR2B receptors were expressed in Xenopus oocytes.
Gene_expression (expressed) of NR1 in oocytes
14) Confidence 0.75 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11323344 Disease Relevance 0 Pain Relevance 0.42
It was noted that gene expression for one type of NMDA receptor proteins, that of Grin3a, was decreased (down-regulated genes, Nervous system development, Table 1).
Gene_expression (expression) of NMDA in Nervous system associated with nmda receptor and nervous system malformation
15) Confidence 0.75 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.43 Pain Relevance 0.32
In this investigation, we show the presence of both free glutamate (microdialysis) and glutamate NMDAR1 receptors (immunohistochemical analyses of tendon biopsies), in tendons from patients with chronic Achilles tendon pain (Achilles tendinosis) and in controls (pain-free tendons).
Gene_expression (presence) of NMDAR1 in tendon associated with pain, glutamate and tendinopathy
16) Confidence 0.66 Published 2001 Journal Knee Surg Sports Traumatol Arthrosc Section Abstract Doc Link 11354854 Disease Relevance 0.41 Pain Relevance 0.59
Malfunctioning NMDA receptor signaling in the prefrontal cortex of KO mice may lead to dysfunction in this brain region, perhaps resulting in the impairments of recognition and spatial working memory that were observed in this study.
Gene_expression (receptor) of NMDA in prefrontal associated with targeted disruption and nmda receptor
17) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.77 Pain Relevance 0.42
GABAA, NMDA and cannabinoid receptor signalling
Gene_expression (signalling) of NMDA associated with cannabinoid receptor
18) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873964 Disease Relevance 0.60 Pain Relevance 0.22
Cells transfected with NR1 and NR2 subunits of the NMDA receptors were grown in the presence of 300 ?
Gene_expression (receptors) of NMDA associated with nmda receptor
19) Confidence 0.65 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0.13 Pain Relevance 0.05
Among those loops, the one from N-methyl-D-aspartate subtype glutamate receptor (NMDAR) to ?
Gene_expression (one) of NMDAR associated with glutamate receptor
20) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894047 Disease Relevance 0.46 Pain Relevance 0.30

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