INT67936

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Context Info
Confidence 0.52
First Reported 1996
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 9.52
Pain Relevance 4.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (JUN) nucleoplasm (JUN) nuclear chromosome (JUN)
aging (JUN) nucleus (JUN) DNA binding (JUN)
Anatomy Link Frequency
thyroid 1
Brain 1
nucleus 1
T lymphocytes 1
JUN (Homo sapiens)
Pain Link Frequency Relevance Heat
electroacupuncture 8 100.00 Very High Very High Very High
Endogenous opioid 1 99.40 Very High Very High Very High
Morphine 3 98.88 Very High Very High Very High
metalloproteinase 90 98.68 Very High Very High Very High
Enkephalin 1 98.06 Very High Very High Very High
Inflammation 281 97.40 Very High Very High Very High
cytokine 103 95.16 Very High Very High Very High
Nicotine 192 94.24 High High
Opioid 7 92.92 High High
Inflammatory mediators 13 92.64 High High
Disease Link Frequency Relevance Heat
Apoptosis 166 99.08 Very High Very High Very High
Thyroid Neoplasm 88 98.52 Very High Very High Very High
Carcinoma 19 98.50 Very High Very High Very High
INFLAMMATION 293 97.40 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 26 96.68 Very High Very High Very High
Asthma 87 96.40 Very High Very High Very High
Necrosis 15 96.00 Very High Very High Very High
Dna Damage 1 96.00 Very High Very High Very High
Cancer 151 95.64 Very High Very High Very High
Colon Cancer 19 94.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
in the expression of both COX-2 and c-Jun proteins and mRNAs.
Transcription (expression) of c-Jun
1) Confidence 0.52 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.98 Pain Relevance 0.03
The 27 upregulated genes encoded seven transcription factors (JUN, EGR1, JUNB, FOS, FOSB, MYCN, and SNAIL1), four of which are components of the AP-1 transcription factor family (JUN, JUNB, FOS, and FOSB).
Transcription (transcription) of JUN
2) Confidence 0.48 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.12 Pain Relevance 0.09
The 27 upregulated genes encoded seven transcription factors (JUN, EGR1, JUNB, FOS, FOSB, MYCN, and SNAIL1), four of which are components of the AP-1 transcription factor family (JUN, JUNB, FOS, and FOSB).
Transcription (transcription) of JUN
3) Confidence 0.48 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.19 Pain Relevance 0.09
As a result, transcription of AP-1-dependent genes takes place and, if this process persists, cells will eventually die by apoptosis.
Transcription (transcription) of AP-1-dependent associated with apoptosis
4) Confidence 0.46 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2929514 Disease Relevance 0.58 Pain Relevance 0.15
B, AP1, and ATF/CREB may function as repressors of transcription by recruiting HDACs to the LTR and promoting the formation of heterochromatin.
Transcription (transcription) of AP1
5) Confidence 0.37 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.24 Pain Relevance 0
Brain substrates activated by electroacupuncture (EA) of different frequencies (II): Role of Fos/Jun proteins in EA-induced transcription of preproenkephalin and preprodynorphin genes.
Spec (investigate) Transcription (transcription) of Jun in Brain associated with enkephalin and electroacupuncture
6) Confidence 0.29 Published 1996 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9037530 Disease Relevance 0 Pain Relevance 0.55
Although no evidence for gene rearrangements or amplification of the nuclear proto-oncogenes has been noted in thyroid carcinomas, in human MTC samples, both a high frequency of c-myc allelic losses [50] and elevated levels of c-myc and c-jun mRNA have been demonstrated [52].
Transcription (levels) of c-jun in thyroid associated with thyroid neoplasm and carcinoma
7) Confidence 0.25 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 0.89 Pain Relevance 0
We demonstrated that morphine and the endogenous opioid beta-endorphin inhibited the transcription of IL-2 in activated human T lymphocytes as well as the activation of the transcription factors AP-1, NFAT, and NF-kappaB, which transactivate IL-2.
Transcription (transcription) of AP-1 in T lymphocytes associated with endogenous opioid and morphine
8) Confidence 0.19 Published 2009 Journal J. Immunol. Section Abstract Doc Link 19561113 Disease Relevance 0.26 Pain Relevance 0.86
and other transcription factors like AP-1 and NF-?
Transcription (transcription) of AP-1
9) Confidence 0.19 Published 2001 Journal Respir Res Section Body Doc Link PMC59562 Disease Relevance 0.26 Pain Relevance 0.12
Upon activation, JNKs translocate to the nucleus to phosphorylate and enhance the transcriptional activity of JUN [7].
Transcription (activity) of JUN in nucleus
10) Confidence 0.17 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.77 Pain Relevance 0.09
The results suggest that ceramide-induced TLR4 signaling causes rapid phosphorylation/transcription of proteins involved in IRF3 and AP-1 transcription, including CREB, Fyn, PLC?
Transcription (transcription) of AP-1
11) Confidence 0.16 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0 Pain Relevance 0.03
The response showed a similar, restricted repertoire in A498 carcinoma cells after three hours (Figure 3C). r-Ceramide upregulated TRAM, Fos and Jun transcription (10.2-, 2.2- and 2.4-fold, respectively).
Transcription (transcription) of Jun associated with carcinoma
12) Confidence 0.12 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0.10 Pain Relevance 0
Activation of ERK5 and the subsequent transcription of c-JUN, but not ERK1/2, can be blocked by cAMP through PKA [17].
Transcription (transcription) of c-JUN
13) Confidence 0.10 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.12 Pain Relevance 0.43
Activation of ERK5 and the subsequent transcription of c-JUN, but not ERK1/2, can be blocked by cAMP through cAMP-dependent protein kinase (PKA) [17].
Transcription (transcription) of c-JUN
14) Confidence 0.10 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.72 Pain Relevance 0.20
and AP-1 transcription factors at the DR-1/AP-1 element, and when considering the competitive binding model, one would expect a decrease in PPAR?
Transcription (factors) of AP-1
15) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0
and AP-1 transcription factors at the DR-1/AP-1 element, and when considering the competitive binding model, one would expect a decrease in PPAR?
Transcription (transcription) of AP-1
16) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0
Mechanistically, it has been proposed that glucocorticoid receptors interact with transcription factors such as activator protein-1 and nuclear factor-?
Transcription (transcription) of activator protein-1
17) Confidence 0.07 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 1.25 Pain Relevance 0.75
Thus, the ability of the transcription factors AP-1 and NF-kappaB to induce gene transcription is attenuated by GR.
Transcription (transcription) of AP-1
18) Confidence 0.02 Published 2001 Journal Immunol. Cell Biol. Section Abstract Doc Link 11488985 Disease Relevance 1.03 Pain Relevance 0.38
The activity of the MMPs is tightly regulated at three levels: transcriptionally, through transcription factors such as activator protein 1, NF?
Transcription (transcription) of activator protein 1 associated with metalloproteinase
19) Confidence 0.02 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154424 Disease Relevance 0 Pain Relevance 0.36

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