INT6794

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Context Info
Confidence 0.53
First Reported 1991
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 37
Total Number 38
Disease Relevance 8.04
Pain Relevance 13.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) aging (Jun) nucleus (Jun)
DNA binding (Jun) transcription factor binding (Jun)
Anatomy Link Frequency
neurons 4
neuronal 3
adrenal medulla 3
spinal cord 2
passage cells 1
Jun (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 86 100.00 Very High Very High Very High
medulla 14 100.00 Very High Very High Very High
COX2 2 100.00 Very High Very High Very High
Nicotine 12 99.98 Very High Very High Very High
Morphine 37 99.90 Very High Very High Very High
Enkephalin 25 99.90 Very High Very High Very High
depression 18 99.86 Very High Very High Very High
Spinal cord 42 99.70 Very High Very High Very High
ketamine 14 99.36 Very High Very High Very High
narcan 13 98.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Repression 1 100.00 Very High Very High Very High
Depression 18 99.86 Very High Very High Very High
Convulsion 7 99.58 Very High Very High Very High
INFLAMMATION 89 98.04 Very High Very High Very High
Temporomandibular Joint Syndrome 4 97.68 Very High Very High Very High
Lung Injury 13 97.16 Very High Very High Very High
Pheochromocytoma 2 97.04 Very High Very High Very High
Neuropathic Pain 2 96.56 Very High Very High Very High
Hypotension 8 96.28 Very High Very High Very High
Injury 15 96.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acute repeated nicotine injections increase enkephalin and decrease AP-1 DNA binding activity in rat adrenal medulla.
Negative_regulation (decrease) of AP-1 in adrenal medulla associated with medulla, nicotine and enkephalin
1) Confidence 0.53 Published 1995 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 7476031 Disease Relevance 0 Pain Relevance 0.56
Repeated acute nicotine injections (3 mg/kg i.p., 7 injections equi-spaced over a 3 h period) effectively increased adrenal tyrosine hydroxylase [3] and [Met5]enkephalin levels and also profoundly decreased adrenal medulla AP-1 DNA binding activity for over 8 h.
Negative_regulation (decreased) of AP-1 in adrenal medulla associated with medulla, nicotine and enkephalin
2) Confidence 0.53 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7476031 Disease Relevance 0 Pain Relevance 0.44
Previously we reported that a single injection of nicotine decreased AP-1 DNA binding activity in adrenal medullae, although chronic bidaily nicotine (and saline) injections increased this binding activity [15].
Negative_regulation (decreased) of AP-1 associated with nicotine
3) Confidence 0.53 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7476031 Disease Relevance 0 Pain Relevance 0.40
In addition, KA-induced AP-1 and ENKCRE-2 DNA-binding activities were diminished by the antibodies against Fos and Jun family proteins.
Negative_regulation (diminished) of AP-1
4) Confidence 0.50 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221929 Disease Relevance 0 Pain Relevance 0.04
These results suggest that inhibition of c-Jun activity is involved in the neuroprotective effects of ketamine and propofol on glutamate-induced injury in neuronal PC12 cells.
Negative_regulation (inhibition) of c-Jun in neuronal associated with glutamate, ketamine and injury
5) Confidence 0.48 Published 2008 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 18362774 Disease Relevance 0.52 Pain Relevance 0.51
As general anesthetics, such as ketamine and propofol, are thought to provide some degree of neuroprotection, this study was intended to test whether the protection of injured neuronal PC12 cells by ketamine and propofol is related to the inhibition of phospho-c-Jun.
Spec (whether) Negative_regulation (inhibition) of phospho-c-Jun in neuronal associated with ketamine
6) Confidence 0.48 Published 2008 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 18362774 Disease Relevance 0.33 Pain Relevance 0.33
When secondary seizure stimulations were given to seizure-sensitive rats, the AP-1 DNA binding activity was attenuated and the components of AP-1 proteins changed transiently.
Negative_regulation (attenuated) of AP-1 associated with convulsion
7) Confidence 0.43 Published 1998 Journal Sheng Li Xue Bao Section Abstract Doc Link 11324547 Disease Relevance 0.50 Pain Relevance 0.16
One hour after vagotomy, c-JUN and JUN B were transynaptically expressed in the area of central termination of sensory vagal neurons and declined within 10 h to basal levels.
Negative_regulation (declined) of JUN in neurons
8) Confidence 0.42 Published 1991 Journal Neuroscience Section Abstract Doc Link 1762686 Disease Relevance 0.11 Pain Relevance 0.30
One hour after vagotomy, c-JUN and JUN B were transynaptically expressed in the area of central termination of sensory vagal neurons and declined within 10 h to basal levels.
Negative_regulation (declined) of JUN in neurons
9) Confidence 0.42 Published 1991 Journal Neuroscience Section Abstract Doc Link 1762686 Disease Relevance 0.11 Pain Relevance 0.30
While c-FOS expression was suppressed in superficial and deep laminae of the spinal cord, NGF1-A and c-JUN was only suppressed in superficial laminae.
Negative_regulation (suppressed) of JUN in spinal cord associated with spinal cord
10) Confidence 0.41 Published 1994 Journal Pain Section Abstract Doc Link 8159434 Disease Relevance 0 Pain Relevance 0.91
Site-dependent inhibition of neuronal c-jun in the brainstem elicited by imidazoline I1 receptor activation: role in rilmenidine-evoked hypotension.
Negative_regulation (inhibition) of c-jun in brainstem associated with medulla and hypotension
11) Confidence 0.41 Published 2005 Journal Eur. J. Pharmacol. Section Title Doc Link 15910806 Disease Relevance 0.46 Pain Relevance 0.42
We hypothesise that inhibition of AP-1 signalling may be involved in the mediation of biological effects of ATRA on PSCs.
Negative_regulation (inhibition) of AP-1 in PSCs
12) Confidence 0.40 Published 2003 Journal Biochem. Pharmacol. Section Abstract Doc Link 12906928 Disease Relevance 0.16 Pain Relevance 0.07
At 2 h following noxious heat stimulation morphine had decreased the number of labelled neurons for c-Fos, Fos B, Krox-24, c-Jun and Jun B to 30-60% of control levels in laminae I-II and to 10-30% in laminae III-VII,X of the spinal cord.
Negative_regulation (decreased) of Jun in neurons associated with spinal cord and morphine
13) Confidence 0.40 Published 1994 Journal Neuroscience Section Abstract Doc Link 8152542 Disease Relevance 0 Pain Relevance 1.20
At 4 h the level of reduction had further increased while Jun D was only moderately reduced to 75% in all laminae of the spinal cord.
Negative_regulation (reduced) of Jun in spinal cord associated with spinal cord
14) Confidence 0.40 Published 1994 Journal Neuroscience Section Abstract Doc Link 8152542 Disease Relevance 0 Pain Relevance 1.12
Acute (2 h, 4 h) and long-term (72 h) treatment with DAMGO time-dependently increased the DNA-binding activity of both AP-1 and NF-kappa B and the stimulation could be abolished or inhibited by concurrent incubation with naloxone.
Negative_regulation (inhibited) of AP-1 associated with narcan
15) Confidence 0.37 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8843097 Disease Relevance 0 Pain Relevance 0.40
Acute (2 h, 4 h) and long-term (72 h) treatment with DAMGO time-dependently increased the DNA-binding activity of both AP-1 and NF-kappa B and the stimulation could be abolished or inhibited by concurrent incubation with naloxone.
Negative_regulation (abolished) of AP-1 associated with narcan
16) Confidence 0.37 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8843097 Disease Relevance 0 Pain Relevance 0.40
RESULTS: Cotransfection of c-Fos antibody significantly decreased glutamate-induced AP-1 activity.
Negative_regulation (decreased) of AP-1
17) Confidence 0.36 Published 2003 Journal Anesthesiology Section Body Doc Link 14508329 Disease Relevance 0.06 Pain Relevance 0
Therefore, these data suggest that melatonin has an inhibitory role in KA-induced gene expression, such as proENK and proDYN mRNA expression, and this may be due to a reduction of KA-induced AP-1 or ENKCRE-2 DNA binding activity.
Negative_regulation (reduction) of AP-1
18) Confidence 0.35 Published 2000 Journal Hippocampus Section Abstract Doc Link 10902893 Disease Relevance 0 Pain Relevance 0.06
At 2 h following noxious heat stimulation morphine had decreased the number of labelled neurons for c-Fos, Fos B, Krox-24, c-Jun and Jun B to 30-60% of control levels in laminae I-II and to 10-30% in laminae III-VII,X of the spinal cord.
Negative_regulation (decreased) of c-Jun in neurons associated with spinal cord and morphine
19) Confidence 0.35 Published 1994 Journal Neuroscience Section Abstract Doc Link 8152542 Disease Relevance 0 Pain Relevance 1.18
Our results suggest that L-ARG plays an important role in inhibiting KA-induced proENK or proDYN mRNA expression, and its inhibitory action may be mediated through reducing the proto-oncoprotein levels, such as c-Fos, Fra-2, FosB, c-Jun, JunD, and JunB.
Negative_regulation (reducing) of c-Jun
20) Confidence 0.34 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602069 Disease Relevance 0 Pain Relevance 0.06

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