INT67951

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Context Info
Confidence 0.43
First Reported 1996
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.08
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gad1) lyase activity (Gad1) intracellular (Gad1)
cytoplasm (Gad1)
Anatomy Link Frequency
efferent neurons 2
neurons 2
striatum 2
prefrontal 2
Gad1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 18 100.00 Very High Very High Very High
Dopamine 4 100.00 Very High Very High Very High
Deafferentation 1 100.00 Very High Very High Very High
Enkephalin 5 99.88 Very High Very High Very High
substance P 5 99.32 Very High Very High Very High
Spinal nerve ligature 1 99.00 Very High Very High Very High
Spinal cord 6 98.44 Very High Very High Very High
Neuropathic pain 6 97.88 Very High Very High Very High
Nucleus accumbens 2 93.68 High High
antinociception 3 93.08 High High
Disease Link Frequency Relevance Heat
Nociception 7 99.96 Very High Very High Very High
Neuropathic Pain 8 97.88 Very High Very High Very High
Gliosis 1 96.16 Very High Very High Very High
Frailty 1 95.60 Very High Very High Very High
Cold Sores 2 92.00 High High
Herpes Simplex Virus 1 91.80 High High
Generalized Anxiety Disorder 15 76.60 Quite High
Schizophrenia 2 75.00 Quite High
Pain 26 68.40 Quite High
Ganglion Cysts 46 65.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Repeated injections of dizocilpine maleate (MK-801) do not suppress the effects of nigrostriatal dopamine deafferentation on glutamate decarboxylase (GAD67) mRNA expression in the adult rat striatum.
Neg (not) Negative_regulation (suppress) of Gene_expression (expression) of GAD67 in striatum associated with glutamate, dopamine and deafferentation
1) Confidence 0.43 Published 1996 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9037536 Disease Relevance 0 Pain Relevance 0.38
These results indicate that the developmental VH lesion changed the striatal expression of D2R and prodynorphin and robustly compromised prefrontal GAD67 expression but did not modify drug-induced expression of any genes examined in this study.
Negative_regulation (changed) of Gene_expression (expression) of GAD67 in prefrontal
2) Confidence 0.42 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12887421 Disease Relevance 0.14 Pain Relevance 0.15
A total loss of neurons expressing glutamate decarboxylase (GAD67), enkephalin or substance P mRNA was observed on a similar circular area, suggesting degeneration of the two populations of striatal efferent neurons.
Negative_regulation (loss) of Gene_expression (expressing) of GAD67 in efferent neurons associated with glutamate, enkephalin and substance p
3) Confidence 0.41 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9406933 Disease Relevance 0.10 Pain Relevance 0.50
More recently, the transfer of GAD67 to DRG neurons by peripheral inoculation of a novel human foamy virus (HFV) was shown to reduce nociceptive responses associated with spinal cord hemisection [6,8].
Negative_regulation (reduce) of Gene_expression (transfer) of GAD67 in neurons associated with nociception and spinal cord
4) Confidence 0.26 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734545 Disease Relevance 0.84 Pain Relevance 1.09

General Comments

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