INT67952

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Context Info
Confidence 0.51
First Reported 1996
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.23
Pain Relevance 2.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gad1) lyase activity (Gad1) intracellular (Gad1)
cytoplasm (Gad1)
Anatomy Link Frequency
striatum 2
basal ganglia 2
CeA 2
Gad1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 29 100.00 Very High Very High Very High
Neuropeptide 5 100.00 Very High Very High Very High
Glutamate 4 100.00 Very High Very High Very High
Deafferentation 1 100.00 Very High Very High Very High
gABA 5 98.12 Very High Very High Very High
agonist 9 97.24 Very High Very High Very High
amygdala 10 96.64 Very High Very High Very High
Nicotine 2 96.00 Very High Very High Very High
Serotonin 2 96.00 Very High Very High Very High
Substantia nigra 3 95.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 6 100.00 Very High Very High Very High
Parkinson's Disease 23 97.76 Very High Very High Very High
Eating Disorder 1 86.92 High High
Stress 4 86.20 High High
Dyskinesias 43 79.64 Quite High
Disease 42 79.32 Quite High
Hypokinesia 2 6.12 Low Low
Cognitive Disorder 8 5.00 Very Low Very Low Very Low
Dystonia 2 5.00 Very Low Very Low Very Low
Chorea 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For instance, a number of studies using in situ hybridization studies have unraveled changes in glutamic acid decarboxylase (GAD) mRNA levels, the rate-limiting enzyme in the synthesis of GABA, in parkinsonian and dyskinetic animal models.
Regulation (changes) of Transcription (levels) of glutamic acid decarboxylase associated with parkinson's disease, gaba and generalized anxiety disorder
1) Confidence 0.51 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2947938 Disease Relevance 0.65 Pain Relevance 0.09
Repeated injections of dizocilpine maleate (MK-801) do not suppress the effects of nigrostriatal dopamine deafferentation on glutamate decarboxylase (GAD67) mRNA expression in the adult rat striatum.
Neg (not) Regulation (effects) of Transcription (expression) of GAD67 in striatum associated with glutamate, dopamine and deafferentation
2) Confidence 0.45 Published 1996 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9037536 Disease Relevance 0 Pain Relevance 0.38
Thereafter, changes in the expression of glutamic acid decarboxylase (GAD)67 mRNA were estimated by in situ hybridization in the central nucleus of the amygdala (CeA), basolateral amygdala (BLA), dorsolateral striatum (dLStr), nucleus accumbens shell (AcS) and core (AcC).
Regulation (changes) of Transcription (expression) of glutamic acid decarboxylase in CeA associated with nucleus accumbens, generalized anxiety disorder and amygdala
3) Confidence 0.45 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18312583 Disease Relevance 0.42 Pain Relevance 0.61
The serotonergic regulation of neuropeptide and glutamic acid decarboxylase (GAD) mRNA level in the rat basal ganglia was investigated by determining the effects of chronic treatment with the serotonin uptake blocker fluoxetine and the serotonin 5-HT2 agonist (+/-)-2,5-dimethoxy-4-iodoamphetamine hydrobromide (DOI).
Regulation (regulation) of Transcription (level) of glutamic acid decarboxylase in basal ganglia associated with generalized anxiety disorder, agonist, neuropeptide, serotonin and fluoxetine
4) Confidence 0.28 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9526047 Disease Relevance 0.10 Pain Relevance 0.57
Selective modifications in GAD67 mRNA levels in striatonigral and striatopallidal pathways correlate to dopamine agonist priming in 6-hydroxydopamine-lesioned rats.
Regulation (modifications) of Transcription (levels) of GAD67 associated with dopamine and agonist
5) Confidence 0.27 Published 2003 Journal Eur. J. Neurosci. Section Title Doc Link 14622157 Disease Relevance 0 Pain Relevance 0.81
The stimulation did not affect neuropeptide or GAD67 mRNA levels in the side contralateral to the dopamine lesion or in intact animals.
Neg (not) Regulation (affect) of Transcription (levels) of GAD67 associated with dopamine and neuropeptide
6) Confidence 0.26 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12077209 Disease Relevance 0.06 Pain Relevance 0.51

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