INT6796

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Context Info
Confidence 0.70
First Reported 1990
Last Reported 2010
Negated 5
Speculated 4
Reported most in Abstract
Documents 165
Total Number 169
Disease Relevance 37.18
Pain Relevance 49.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) aging (Jun) nucleus (Jun)
DNA binding (Jun) transcription factor binding (Jun)
Anatomy Link Frequency
neurons 12
hippocampus 9
spinal cord 5
striatum 4
brain 3
Jun (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 30 100.00 Very High Very High Very High
noradrenaline 4 100.00 Very High Very High Very High
neuralgia 3 100.00 Very High Very High Very High
alcohol 18 99.98 Very High Very High Very High
MU agonist 10 99.98 Very High Very High Very High
Pain 56 99.94 Very High Very High Very High
withdrawal 53 99.92 Very High Very High Very High
Thalamus 22 99.92 Very High Very High Very High
Freund adjuvant 24 99.84 Very High Very High Very High
Dorsal horn 10 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Coronary Heart Disease 24 99.96 Very High Very High Very High
Cancer 182 99.84 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

22 99.84 Very High Very High Very High
Depression 20 99.80 Very High Very High Very High
Urological Neuroanatomy 15 99.68 Very High Very High Very High
Pain 42 99.64 Very High Very High Very High
INFLAMMATION 572 99.58 Very High Very High Very High
Hypersensitivity 17 99.56 Very High Very High Very High
Stress 192 99.38 Very High Very High Very High
Cv Unclassified Under Development 15 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Striatal c-Fos protein levels and AP-1 DNA binding activity were increased in rats receiving paired morphine compared with rats that did not receive morphine but not in rats receiving morphine without the CS.
Positive_regulation (increased) of AP-1 associated with morphine
1) Confidence 0.70 Published 1998 Journal Neuroreport Section Abstract Doc Link 9855286 Disease Relevance 0 Pain Relevance 1.12
Basal levels of c-jun protein and AP-1 DNA binding activity were elevated in the P7 hippocampus, to values greater than induced levels in adult hippocampus.
Positive_regulation (elevated) of AP-1 in hippocampus associated with hippocampus
2) Confidence 0.68 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8294905 Disease Relevance 0.14 Pain Relevance 0.52
Despite producing seizures at postnatal day (P) 7, kainate failed to induce AP-1 or opiate gene expression and did not increase AP-1 DNA binding activity at this age.
Neg (not) Positive_regulation (increase) of AP-1 associated with convulsion and opiate
3) Confidence 0.68 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8294905 Disease Relevance 0.10 Pain Relevance 0.45
The ontogeny of kainate induction of AP-1 mRNAs, proteins, and DNA binding activities was examined in the rat hippocampus.
Positive_regulation (induction) of AP-1 in hippocampus associated with hippocampus
4) Confidence 0.68 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8294905 Disease Relevance 0.07 Pain Relevance 0.28
At P14, induction of AP-1 and preproenkephalin (but not preprodynorphin) mRNAs was observed with kainate treatment, but the time course for inductions was delayed relative to kainate inductions in the adult hippocampus.
Positive_regulation (induction) of AP-1 in hippocampus associated with hippocampus
5) Confidence 0.68 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8294905 Disease Relevance 0.15 Pain Relevance 0.56
We have previously shown that in cell extracts from rat striatum, cyclic AMP response element (CRE) binding protein (CREB), rather than AP-1 proteins, preferentially interacts with the CRE-2 element of the proenkephalin second messenger-inducible enhancer, even under conditions in which AP-1 proteins are highly induced.
Positive_regulation (induced) of AP-1 in striatum
6) Confidence 0.67 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7643080 Disease Relevance 0 Pain Relevance 0
Furthermore, by using gel shift assay we found an induction of AP-1 by caffeine (100 mg/kg) in striatum, which peaked 2 hr after administration and was clearly increased after 4 hr. c-Fos, c-Jun, and JunB proteins were components of the AP-1.
Positive_regulation (induction) of AP-1 in striatum
7) Confidence 0.66 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7751931 Disease Relevance 0 Pain Relevance 0.05
These effects could result from direct post-translational activation of Jun and CREB, as shown using GAL4-Jun or GAL4-CREB fusion proteins.
Positive_regulation (activation) of Jun
8) Confidence 0.65 Published 1998 Journal DNA Cell Biol. Section Abstract Doc Link 9502431 Disease Relevance 0.08 Pain Relevance 0
Co-induction of jun B and c-fos in a subset of neurons in the spinal cord.
Positive_regulation (induction) of jun in neurons associated with pain and spinal cord
9) Confidence 0.63 Published 1991 Journal Oncogene Section Title Doc Link 1900356 Disease Relevance 0.34 Pain Relevance 0.46
A mu-receptor opioid agonist induces AP-1 and NF-kappa B transcription factor activity in primary cultures of rat cortical neurons.
Positive_regulation (induces) of AP-1 in neurons associated with mu agonist and analgesic
10) Confidence 0.60 Published 1996 Journal Neurosci. Lett. Section Title Doc Link 8843097 Disease Relevance 0 Pain Relevance 0.57
These results indicate a mu-opioid receptor-related co-induction of AP-1 and NF-kappa B transcription factors in cultured cortical neurons.
Positive_regulation (induction) of AP-1 in neurons associated with opioid receptor
11) Confidence 0.60 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8843097 Disease Relevance 0 Pain Relevance 0.39
In fact, we found in this study that capsaicin inhibits c-jun induction, stimulated by MNNG, in the spleen, heart, stomach and lung.
Positive_regulation (induction) of c-jun in lung associated with qutenza
12) Confidence 0.60 Published 1999 Journal Cancer Lett. Section Abstract Doc Link 10463771 Disease Relevance 0.24 Pain Relevance 0.52
Since MNNG, a methylating agent, is a powerful carcinogen that is very effective in the induction of c-jun mRNA, the results suggest that capsaicin uptake in the diet could play a role in inhibition of tumorigenesis induced by MNNG.
Positive_regulation (induction) of c-jun mRNA associated with qutenza
13) Confidence 0.60 Published 1999 Journal Cancer Lett. Section Abstract Doc Link 10463771 Disease Relevance 0.22 Pain Relevance 0.51
The Jun-IR induced by nerve transection disappeared after nerve regeneration.
Positive_regulation (induced) of Jun in nerve
14) Confidence 0.60 Published 1991 Journal Brain Res. Section Abstract Doc Link 1726060 Disease Relevance 0 Pain Relevance 0.17
There was a strong and selective induction of Jun-IR in moto- and DRG neurons after peripheral nerve transection or crush, or colchicine- or vinblastine-induced block of axonal transport.
Positive_regulation (induction) of Jun in neurons
15) Confidence 0.60 Published 1991 Journal Brain Res. Section Abstract Doc Link 1726060 Disease Relevance 0 Pain Relevance 0.15
In contrast, Jun, Fos and Krox proteins were all induced transynaptically in spinal dorsal horn neurons following electrical stimulation of the C-fibers in the afferent nerves.
Positive_regulation (induced) of Jun in neurons associated with c fibre and dorsal horn neuron
16) Confidence 0.60 Published 1991 Journal Brain Res. Section Abstract Doc Link 1726060 Disease Relevance 0 Pain Relevance 0.18
After capsaicin (25 mg/kg, s.c.), a rapid increase in both c-fos and c-jun mRNA levels was observed in adrenal medulla.
Positive_regulation (increase) of c-jun mRNA in adrenal medulla associated with medulla and qutenza
17) Confidence 0.60 Published 1991 Journal Neurosci. Lett. Section Abstract Doc Link 1922926 Disease Relevance 0 Pain Relevance 0.57
KA-induced increases of AP-1 and ENKCRE-2 DNA-binding activities were also attenuated by CHX.
Positive_regulation (increases) of AP-1
18) Confidence 0.60 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221929 Disease Relevance 0 Pain Relevance 0.06
In electrophoretic mobility shift-assay, both AP-1 and ENKCRE-2 DNA-binding activities were increased by KA.
Positive_regulation (increased) of AP-1
19) Confidence 0.60 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221929 Disease Relevance 0 Pain Relevance 0.07
In addition, KA-induced AP-1 and ENKCRE-2 DNA-binding activities were diminished by the antibodies against Fos and Jun family proteins.
Positive_regulation (induced) of AP-1
20) Confidence 0.60 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221929 Disease Relevance 0 Pain Relevance 0.06

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