INT67974

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Context Info
Confidence 0.37
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.13
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bdkrb2) signal transduction (Bdkrb2) plasma membrane (Bdkrb2)
signal transducer activity (Bdkrb2)
Bdkrb2 (Mus musculus)
Pain Link Frequency Relevance Heat
b2 receptor 7 100.00 Very High Very High Very High
antagonist 24 99.76 Very High Very High Very High
bradykinin 11 99.56 Very High Very High Very High
Opioid 14 93.40 High High
Pain 2 92.84 High High
Inflammation 25 92.44 High High
Morphine 36 87.84 High High
agonist 7 67.44 Quite High
cocaine 38 66.16 Quite High
addiction 28 61.84 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 19 99.88 Very High Very High Very High
Pressure Volume 2 Under Development 1 99.60 Very High Very High Very High
Increased Venous Pressure Under Development 1 95.08 Very High Very High Very High
Pain 2 92.84 High High
INFLAMMATION 30 92.44 High High
Avian Sarcoma 1 83.92 Quite High
Respiratory Syncytial Virus 1 82.48 Quite High
Stress 17 62.72 Quite High
Cv Unclassified Under Development 12 59.28 Quite High
Aids-related Complex 6 37.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hypotension in transgenic mice overexpressing human bradykinin B2 receptor.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of B2 associated with targeted disruption, pressure volume 2 under development and b2 receptor
1) Confidence 0.37 Published 1997 Journal Hypertension Section Title Doc Link 9039147 Disease Relevance 1.00 Pain Relevance 0.38
Real-time PCR was performed for GATA-3, T-bet, MCP-1, HO-1, B1R and B2R expression using SYBR Green assay (Applied Biosystem).
Positive_regulation (performed) of Gene_expression (expression) of B2R
2) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 0.06 Pain Relevance 0.15
Our pharmacological dissection of drug-regulated gene expression profiles showed the inhibitory effects of CRFR1 and GR antagonists on ethanol-activated gene expression of the B2 and B3 subclusters.
Positive_regulation (activated) of Gene_expression (expression) of B2 associated with antagonist
3) Confidence 0.14 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0.06 Pain Relevance 0.38
Similar effects of CHX were observed on the induction of gene expression pattern B2 in response to heroin (CHX blocked 106% of activation, 6% of activation below basal level, P < 0.001) and ethanol (CHX blocked 104% of activation, P < 0.001) (Figure 4d, e).
Positive_regulation (induction) of Gene_expression (expression) of B2
4) Confidence 0.14 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0 Pain Relevance 0.20

General Comments

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