INT67975

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Context Info
Confidence 0.68
First Reported 1997
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 38
Total Number 38
Disease Relevance 21.69
Pain Relevance 17.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bdkrb2) signal transduction (Bdkrb2) plasma membrane (Bdkrb2)
signal transducer activity (Bdkrb2)
Anatomy Link Frequency
tail 2
brain 2
nervous system 2
sensory neurons 1
blood 1
Bdkrb2 (Mus musculus)
Pain Link Frequency Relevance Heat
bradykinin 487 100.00 Very High Very High Very High
b2 receptor 353 100.00 Very High Very High Very High
cytokine 122 99.66 Very High Very High Very High
nociceptor 2 99.56 Very High Very High Very High
Nicotine 699 99.54 Very High Very High Very High
Inflammation 515 99.46 Very High Very High Very High
antagonist 167 99.46 Very High Very High Very High
B1 receptor 95 99.44 Very High Very High Very High
Neuropeptide 4 99.30 Very High Very High Very High
calcitonin gene related peptide 2 98.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 14 99.96 Very High Very High Very High
Targeted Disruption 124 99.88 Very High Very High Very High
Reperfusion Injury 224 99.84 Very High Very High Very High
Anaplastic Astrocytoma 2 99.84 Very High Very High Very High
Nociception 19 99.68 Very High Very High Very High
Pressure Volume 2 Under Development 2 99.60 Very High Very High Very High
Multiple Sclerosis 602 99.56 Very High Very High Very High
INFLAMMATION 579 99.46 Very High Very High Very High
Brain Injury 7 99.28 Very High Very High Very High
Stress 31 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two transgenic mouse lines expressing the human BK B2 receptor showed a significant reduction of systolic tail-cuff blood pressure (84 +/- 1 mm Hg, n = 28; 80 +/- 1 mm Hg, n = 24; P < 0.001) compared with the control littermates (97 +/- 1 mm Hg, n = 52).
Gene_expression (expressing) of BK B2 receptor in tail associated with targeted disruption, b2 receptor and bradykinin
1) Confidence 0.68 Published 1999 Journal Immunopharmacology Section Abstract Doc Link 10604518 Disease Relevance 0.97 Pain Relevance 0.63
While B2R is constitutively expressed in many tissues, B1R expression is thought to be absent, but induced under proinflammatory conditions.
Gene_expression (expressed) of B2R
2) Confidence 0.66 Published 2003 Journal J. Comp. Neurol. Section Abstract Doc Link 12966562 Disease Relevance 0.37 Pain Relevance 0.27
Two transgenic mouse lines expressing the human B2 receptor resulted in a significant reduction of blood pressure (84.2 +/- 0.6 mm Hg, n = 28; 76.9 +/- 0.8 mm Hg, n = 24; P < .001) compared with the control littermates (96.9 +/- 0.4 mm Hg, n = 52).
Gene_expression (expressing) of B2 in blood associated with targeted disruption and b2 receptor
3) Confidence 0.62 Published 1997 Journal Hypertension Section Abstract Doc Link 9039147 Disease Relevance 0.99 Pain Relevance 0.37
Melanoma cells expressed B(1) and B(2) receptors and kininogen.
Gene_expression (expressed) of B(2)
4) Confidence 0.58 Published 2010 Journal Eur J Pain Section Body Doc Link 19932979 Disease Relevance 0.05 Pain Relevance 0
The expression of kinin B(1), but not B(2), receptor mRNA was markedly increased in the L4/5 dorsal root ganglia on the melanoma-bearing side.
Gene_expression (expression) of B(2) in dorsal root ganglia
5) Confidence 0.58 Published 2010 Journal Eur J Pain Section Body Doc Link 19932979 Disease Relevance 0.06 Pain Relevance 0
Real-time PCR was performed for GATA-3, T-bet, MCP-1, HO-1, B1R and B2R expression using SYBR Green assay (Applied Biosystem).
Gene_expression (expression) of B2R
6) Confidence 0.54 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 0.06 Pain Relevance 0.15
B2R is constitutively expressed under physiological conditions and is responsible for most kinin effects [9].
Gene_expression (expressed) of B2R
7) Confidence 0.54 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.01 Pain Relevance 0.49
Chen et al have also shown that the B2 receptor is widely expressed within rat brain [45].
Gene_expression (expressed) of B2 receptor in brain associated with b2 receptor
8) Confidence 0.53 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 0.49 Pain Relevance 0.61
Hypotension in transgenic mice overexpressing human bradykinin B2 receptor.
Gene_expression (overexpressing) of B2 associated with targeted disruption, pressure volume 2 under development and b2 receptor
9) Confidence 0.48 Published 1997 Journal Hypertension Section Title Doc Link 9039147 Disease Relevance 1.00 Pain Relevance 0.38
These results showed that B1R deletion was beneficial throughout different reperfusion times; meanwhile protection under B2R absence was only seen at the beginning of this process.
Neg (absence) Gene_expression (absence) of B2R
10) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 0.55 Pain Relevance 0.27
In agreement with this, a previous study have shown that in renal IRI, early B2R deletion was associated with decreased serum creatine levels, ROS production, cell death and TNF-?
Gene_expression (deletion) of B2R associated with reperfusion injury and death
11) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 0.82 Pain Relevance 0.15
0.005), which was not observed by B2R antagonism (HOE-140) (Figure 2C).
Gene_expression (antagonism) of B2R
12) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 0.70 Pain Relevance 0.25
Absence of B2 receptor did not modulate TNF-?
Neg (Absence) Gene_expression (Absence) of B2 receptor associated with b2 receptor
13) Confidence 0.46 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 1.02 Pain Relevance 0.35
B2R are constitutively expressed, while B1R are inducible.
Gene_expression (expressed) of B2R
14) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.00 Pain Relevance 0.38
In B1KO mice, B2R expression was not modified (data not shown).
Gene_expression (expression) of B2R
15) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 0.34 Pain Relevance 0.26
Previous studies using rodent models of traumatic brain injury have corroborated the finding that B2 receptor is present and involved in cerebral alterations [61,62].
Gene_expression (present) of B2 receptor in brain associated with b2 receptor and brain injury
16) Confidence 0.41 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 1.21 Pain Relevance 0.47
Studies have demonstrated that pro-inflammatory cytokines regulate B1 and B2 receptor expression [11,22,23] and, conversely, blockade of kinins receptors modifies expression of cytokines and chemokines [24,25].
Gene_expression (expression) of B2 receptor associated with chemokine, inflammation, b2 receptor and cytokine
17) Confidence 0.41 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 0.95 Pain Relevance 0.99
The B2 receptor is constitutively expressed in various cell types, including endothelial cells, nerve fibers, leukocytes and mast cells [3,4].
Gene_expression (expressed) of B2 receptor in mast cells associated with b2 receptor
18) Confidence 0.41 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 0.92 Pain Relevance 0.61
B2-/- and WT mice were immunized subcutaneously at the base of the tail with an emulsion containing 100 ?
Gene_expression (immunized) of B2 in tail
19) Confidence 0.40 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 0.95 Pain Relevance 0.37
Na(v)1.9 is present in nociceptor sensory neurons that express TRPV1, bradykinin B2, and purinergic P2X3 receptors.
Gene_expression (express) of bradykinin B2 in sensory neurons associated with nociceptor and bradykinin
20) Confidence 0.40 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 17167076 Disease Relevance 0.58 Pain Relevance 0.86

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