INT67980

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Context Info
Confidence 0.49
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.89
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL2) extracellular space (CCL2) aging (CCL2)
extracellular region (CCL2) cell adhesion (CCL2) cytoskeleton organization (CCL2)
Anatomy Link Frequency
plasma 3
HCEC 2
monocyte 1
CCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 89 99.98 Very High Very High Very High
cytokine 14 99.08 Very High Very High Very High
ischemia 10 98.58 Very High Very High Very High
agonist 15 98.32 Very High Very High Very High
Inflammatory response 1 97.80 Very High Very High Very High
Angina 9 97.44 Very High Very High Very High
Inflammation 54 96.64 Very High Very High Very High
chemokine 24 96.56 Very High Very High Very High
cINOD 2 31.92 Quite Low
fibrosis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 101 99.98 Very High Very High Very High
Cardiovascular Disease 23 99.54 Very High Very High Very High
Myocardial Infarction 14 99.28 Very High Very High Very High
Hypoxia 4 98.76 Very High Very High Very High
Cv Unclassified Under Development 10 98.58 Very High Very High Very High
INFLAMMATION 58 97.80 Very High Very High Very High
Cv General 3 Under Development 7 97.44 Very High Very High Very High
Cicatrix 1 95.56 Very High Very High Very High
Retinal Vein Occlusion 8 92.72 High High
Diabetic Macular Edema 13 91.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, circulating MCP-1 levels are elevated in patients with acute myocardial infarction and in those with unstable angina, but not in patients with stable angina.
Neg (not) Positive_regulation (elevated) of Positive_regulation (circulating) of MCP-1 associated with angina and myocardial infarction
1) Confidence 0.49 Published 2002 Journal Clin Cardiol Section Abstract Doc Link 12000070 Disease Relevance 0.76 Pain Relevance 0.23
Interestingly, the patients with PDR/CRVO showed increase of VEGF, but not DME/BRVO which had a significant increase of IL-6, IL-8, and MCP-1 (Figure 1).
Positive_regulation (increase) of Positive_regulation (increase) of MCP-1
2) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780733 Disease Relevance 1.20 Pain Relevance 0.03
In this study, we show that human cere-bromicrovascular endothelial cells (HCEC) subjected to a 4 h in vitro ischemia (hypoxia + glucose deprivation) followed by a 4-24 h recovery express elevated levels of ICAM-1, IL-8, and MCP-1 mRNAs (semi-quantitative RT-PCR) and secrete increased amounts of the immunoreactive chemokines IL-8 and MCP-1 (ELISA).
Positive_regulation (elevated) of Positive_regulation (levels) of MCP-1 in HCEC associated with chemokine, hypoxia and ischemia
3) Confidence 0.38 Published 2000 Journal Acta Neurochir. Suppl. Section Abstract Doc Link 11450070 Disease Relevance 0.97 Pain Relevance 0.43
Plasma levels of the monocyte chemotactic and activating factor/monocyte chemoattractant protein-1 are elevated in patients with acute myocardial infarction.
Positive_regulation (elevated) of in Plasma Positive_regulation (activating) of chemoattractant protein-1 in monocyte associated with myocardial infarction and cytokine
4) Confidence 0.30 Published 1997 Journal J. Mol. Cell. Cardiol. Section Title Doc Link 9040055 Disease Relevance 0.98 Pain Relevance 0.37
2AAR displayed a marked activation of ERK2 in response to CCL2 and to UK 14'304 (Figure 3B lane 8 and 9).
Positive_regulation (activation) of Positive_regulation (response) of CCL2
5) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855346 Disease Relevance 0.16 Pain Relevance 0.26
The plasma IL-6 and MCP-1 concentrations are also increased after percutaneous coronary intervention (PCI), and late restenosis is correlated with an increase in IL-6 or MCP-1 concentrations after the procedure.
Positive_regulation (increase) of Positive_regulation (concentrations) of MCP-1 in plasma associated with cardiovascular disease
6) Confidence 0.19 Published 2003 Journal Curr Vasc Pharmacol Section Abstract Doc Link 15320854 Disease Relevance 1.13 Pain Relevance 0.29
Compared with controls, patients with RA had significantly higher levels of, sICAM-1, MCP-1 and VWF, with a tendency also for sVCAM-1 to be higher (P = 0.059; Table 3).
Positive_regulation (had) of Positive_regulation (levels) of MCP-1 associated with rheumatoid arthritis
7) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945061 Disease Relevance 0.69 Pain Relevance 0.23

General Comments

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