INT67981

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Context Info
Confidence 0.70
First Reported 1997
Last Reported 2011
Negated 5
Speculated 6
Reported most in Body
Documents 165
Total Number 171
Disease Relevance 136.84
Pain Relevance 61.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL2) extracellular space (CCL2) aging (CCL2)
extracellular region (CCL2) cell adhesion (CCL2) cytoskeleton organization (CCL2)
Anatomy Link Frequency
monocyte 23
plasma 21
macrophage 6
HCEC 6
blood 5
CCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2390 100.00 Very High Very High Very High
cytokine 1802 100.00 Very High Very High Very High
chemokine 1158 100.00 Very High Very High Very High
Angina 127 100.00 Very High Very High Very High
opioid receptor 124 100.00 Very High Very High Very High
addiction 12 100.00 Very High Very High Very High
Morphine 406 99.98 Very High Very High Very High
ischemia 65 99.98 Very High Very High Very High
endometriosis 543 99.96 Very High Very High Very High
Neuritis 25 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2802 100.00 Very High Very High Very High
Adhesions 271 100.00 Very High Very High Very High
Syndrome 154 100.00 Very High Very High Very High
Myocardial Infarction 121 100.00 Very High Very High Very High
Angina 25 100.00 Very High Very High Very High
Cv Unclassified Under Development 68 99.98 Very High Very High Very High
Endometriosis 675 99.96 Very High Very High Very High
Metabolic Syndrome 24 99.92 Very High Very High Very High
Experimental Autoimmune Neuritis 18 99.92 Very High Very High Very High
Systemic Lupus Erythematosus 515 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the course of testing the hypothesis that morphine would stimulate CCL2 production by neurons, three observations were made: 1) CCL2, which was the only chemokine examined that was constitutively expressed by neurons under our experimental conditions, was significantly upregulated in neurons by exposure to morphine; 2) morphine's enhancement of CCL2 was specific for neurons, as witnessed by a lack of response of astrocytes and microglia to morphine under our experimental conditions; and 3) morphine's potentiation of neuronal CCL2 production involves the MOR.
Positive_regulation (enhancement) of CCL2 in astrocytes associated with chemokine, opioid receptor and morphine
1) Confidence 0.70 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1712222 Disease Relevance 0 Pain Relevance 1.19
We observed that MCP-1 was induced by chronic constriction of the sciatic nerve in DRG sensory neurons, spinal cord motor neurons and in the superficial dorsal horn, ipsilateral to the injury.
Positive_regulation (induced) of MCP-1 in sensory neurons associated with injury, dorsal horn, sciatic nerve and spinal cord
2) Confidence 0.69 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16524371 Disease Relevance 0.73 Pain Relevance 0.64
Indeed, circulating MCP-1 levels are elevated in patients with acute myocardial infarction and in those with unstable angina, but not in patients with stable angina.
Neg (not) Positive_regulation (elevated) of MCP-1 associated with angina and myocardial infarction
3) Confidence 0.67 Published 2002 Journal Clin Cardiol Section Abstract Doc Link 12000070 Disease Relevance 0.76 Pain Relevance 0.23
Moreover, an increase in the monocyte chemoattractant protein-1 (MCP-1) message was found in the preclinical stage of EAN, suggesting the critical role of MCP-1 for inducing mononuclear cell infiltrations in this model.
Positive_regulation (ncrease ) of monocyte chemoattractant protein-1 in mononuclear cell associated with neuritis
4) Confidence 0.67 Published 1999 Journal J. Neurovirol. Section Abstract Doc Link 10190687 Disease Relevance 0.67 Pain Relevance 0.67
One of our most important finding is that the major three factors: IL-6, IL-8, and MCP-1 were commonly upregulated in all the examined diseases (Figure 1) and were correlated with each other without any independent change (Figure 3).
Spec (examined) Positive_regulation (upregulated) of MCP-1 associated with disease
5) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780733 Disease Relevance 0.70 Pain Relevance 0.13
The three factors: IL-6, IL-8, and MCP-1 were found to be commonly upregulated and contribute to the formation of various vitreoretinal diseases.
Positive_regulation (upregulated) of MCP-1 associated with disease
6) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780733 Disease Relevance 1.09 Pain Relevance 0.14
Since the three factors: IL-6, IL-8 and MCP-1 were commonly upregulated in all the examined five diseases (DME, PDR, BRVO, CRVO, and RRD), a Spearman's correlation analysis was performed between the three factors.
Spec (examined) Positive_regulation (upregulated) of MCP-1 associated with disease
7) Confidence 0.63 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780733 Disease Relevance 0.89 Pain Relevance 0
In the course of testing the hypothesis that morphine would stimulate CCL2 production by neurons, three observations were made: 1) CCL2, which was the only chemokine examined that was constitutively expressed by neurons under our experimental conditions, was significantly upregulated in neurons by exposure to morphine; 2) morphine's enhancement of CCL2 was specific for neurons, as witnessed by a lack of response of astrocytes and microglia to morphine under our experimental conditions; and 3) morphine's potentiation of neuronal CCL2 production involves the MOR.
Positive_regulation (upregulated) of CCL2 in astrocytes associated with chemokine, opioid receptor and morphine
8) Confidence 0.61 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1712222 Disease Relevance 0 Pain Relevance 1.34
A significant increase in cerebrospinal fluid MCP-1 level but not serum level was seen in the patients with ALS compared to the control subjects.
Positive_regulation (increase) of MCP-1 in cerebrospinal fluid associated with motor neuron diseases
9) Confidence 0.60 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 14597108 Disease Relevance 0.62 Pain Relevance 0.18
Neuronal MCP-1 induction was followed by surrounding microglial activation.
Positive_regulation (induction) of MCP-1 in Neuronal
10) Confidence 0.60 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16524371 Disease Relevance 0.76 Pain Relevance 0.60
Interestingly, the patients with PDR/CRVO showed increase of VEGF, but not DME/BRVO which had a significant increase of IL-6, IL-8, and MCP-1 (Figure 1).
Positive_regulation (increase) of MCP-1
11) Confidence 0.55 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780733 Disease Relevance 1.17 Pain Relevance 0.03
The plasma level of MCAF/MCP-1 in myocardial infarction tended to increase at 3 h after the onset of chest pain (133 +/- 19 pg/ml, P= 0.06) and was significantly elevated at 9 h (143 +/- 20 pg/ml) when compared with that in angina pectoris (87 +/- 6 pg/ml, P<0.05).
Positive_regulation (elevated) of MCP-1 in plasma associated with angina and myocardial infarction
12) Confidence 0.52 Published 1997 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 9040055 Disease Relevance 1.31 Pain Relevance 0.65
The MCAF/MCP-1 level remained increased during the 24-hours observation period (P<0.01), and maximum level (168 +/- 13 pg/ml) was seen at 24 hour.
Positive_regulation (increased) of MCAF
13) Confidence 0.52 Published 1997 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 9040055 Disease Relevance 1.22 Pain Relevance 0.64
The MCAF/MCP-1 level remained increased during the 24-hours observation period (P<0.01), and maximum level (168 +/- 13 pg/ml) was seen at 24 hour.
Positive_regulation (increased) of MCP-1
14) Confidence 0.52 Published 1997 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 9040055 Disease Relevance 1.22 Pain Relevance 0.64
The plasma level of MCAF/MCP-1 in myocardial infarction tended to increase at 3 h after the onset of chest pain (133 +/- 19 pg/ml, P= 0.06) and was significantly elevated at 9 h (143 +/- 20 pg/ml) when compared with that in angina pectoris (87 +/- 6 pg/ml, P<0.05).
Positive_regulation (elevated) of MCAF in plasma associated with angina and myocardial infarction
15) Confidence 0.52 Published 1997 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 9040055 Disease Relevance 1.31 Pain Relevance 0.65
The MCP-1 plasma levels were elevated in the patients with Kawasaki disease (443.0±473.1 pg/mL) and those with acute febrile illnesses (328.6±261.1 pg/mL) compared with Henoch-Schönlein purpura group (82.9±79.0 pg/mL) (p<0.05) (Table 2, Fig. 2).
Positive_regulation (elevated) of MCP-1 in plasma associated with purpura, mucocutaneous lymph node syndrome and fever
16) Confidence 0.52 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816295 Disease Relevance 0.95 Pain Relevance 0
In addition, the plasma levels of MCP-1 were not elevated in 8 patients with Kawasaki disease, with less than 100 pg/mL.


Neg (not) Positive_regulation (elevated) of MCP-1 in plasma associated with mucocutaneous lymph node syndrome
17) Confidence 0.52 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816295 Disease Relevance 1.02 Pain Relevance 0.13
However, the plasma levels of MCP-1 were not elevated consistently.
Neg (not) Positive_regulation (elevated) of MCP-1 in plasma
18) Confidence 0.52 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816295 Disease Relevance 1.60 Pain Relevance 0.26
Valbuena et al. also detected elevation of MCP-1 in response to the infection of spotted fever group rickettsiae (34).
Positive_regulation (elevation) of MCP-1 associated with meningitis, rickettsiaceae infection and infection
19) Confidence 0.52 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816295 Disease Relevance 2.13 Pain Relevance 0.30
Relatively, a recent report documented significantly higher MCP-1
Positive_regulation (documented) of MCP-1
20) Confidence 0.50 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234089 Disease Relevance 0.05 Pain Relevance 0

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