INT67982

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Context Info
Confidence 0.04
First Reported 1997
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.33
Pain Relevance 2.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRD1) cytoplasm (OPRD1) signal transducer activity (OPRD1)
Anatomy Link Frequency
adrenal medulla 2
VTA 2
OPRD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 7 100.00 Very High Very High Very High
agonist 5 100.00 Very High Very High Very High
midbrain 3 100.00 Very High Very High Very High
medulla 2 100.00 Very High Very High Very High
mu opioid receptor 1 100.00 Very High Very High Very High
Nucleus accumbens 4 99.68 Very High Very High Very High
analgesia 1 95.64 Very High Very High Very High
alcohol 13 95.24 Very High Very High Very High
Endogenous opioid 4 94.00 High High
antagonist 5 87.00 High High
Disease Link Frequency Relevance Heat
Stress 1 94.92 High High
Pain 1 86.84 High High
Recurrence 1 75.52 Quite High
Alcohol Addiction 1 75.00 Quite High
Drug Dependence 1 33.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Simultaneous activation of the delta opioid receptor (deltaOR)/sensory neuron-specific receptor-4 (SNSR-4) hetero-oligomer by the mixed bivalent agonist bovine adrenal medulla peptide 22 activates SNSR-4 but inhibits deltaOR signaling.
Positive_regulation (activates) of Positive_regulation (activation) of delta opioid receptor in adrenal medulla associated with medulla, agonist and opioid receptor
1) Confidence 0.04 Published 2006 Journal Mol. Pharmacol. Section Title Doc Link 16682504 Disease Relevance 0.09 Pain Relevance 0.36
One hypothetical model proposes that reward results from activation of mu-opioid receptors in the VTA and/or delta-receptor in the NAC; both these nuclei are targets of endogenous beta-endorphin.
Positive_regulation (results) of Positive_regulation (activation) of delta-receptor in VTA associated with nucleus accumbens, mu opioid receptor and midbrain
2) Confidence 0.03 Published 1997 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9040115 Disease Relevance 0.15 Pain Relevance 1.40
We have addressed the possibility that removal of maternal milk is the stimulus for the weaning-induced delta-receptor activation by studying the effect of lactating and nonlactating surrogate mothers and two milk substitutes (casein-rich and casein-free) on opioid receptor control of swim SIA.
Positive_regulation (induced) of Positive_regulation (activation) of delta-receptor associated with opioid receptor
3) Confidence 0.01 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11181901 Disease Relevance 0.09 Pain Relevance 0.27

General Comments

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