INT67985

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Context Info
Confidence 0.44
First Reported 1997
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 9.36
Pain Relevance 3.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 4
Saa (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 452 99.44 Very High Very High Very High
Angina 8 98.92 Very High Very High Very High
spinal inflammation 41 92.08 High High
Inflammatory response 60 91.32 High High
Pain 3 88.12 High High
spondylitis 3 86.80 High High
chemokine 6 77.68 Quite High
Inflammatory marker 4 50.00 Quite Low
rheumatoid arthritis 4 41.88 Quite Low
cytokine 24 30.56 Quite Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 20 100.00 Very High Very High Very High
Pancreatitis 10 99.78 Very High Very High Very High
Stress 337 99.44 Very High Very High Very High
Cancer 13 99.06 Very High Very High Very High
Cv General 3 Under Development 8 98.92 Very High Very High Very High
Injury 5 98.50 Very High Very High Very High
Infection 11 98.34 Very High Very High Very High
INFLAMMATION 333 97.68 Very High Very High Very High
Low Back Pain 44 92.08 High High
Atherosclerosis 113 90.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HC treatment significantly up-regulates, for example, all four SAA isotype genes (Figure 4a), which is consistent with the observed changes in SAA protein concentrations in plasma (compare Table 1).
Spec (observed) Regulation (changes) of SAA in plasma associated with inflammation
1) Confidence 0.44 Published 2007 Journal Genome Biol Section Body Doc Link PMC2375038 Disease Relevance 1.87 Pain Relevance 0.59
HC treatment significantly up-regulates, for example, all four SAA isotype genes (Figure 4a), which is consistent with the observed changes in SAA protein concentrations in plasma (compare Table 1).
Regulation (regulates) of SAA in plasma associated with inflammation
2) Confidence 0.32 Published 2007 Journal Genome Biol Section Body Doc Link PMC2375038 Disease Relevance 1.89 Pain Relevance 0.59
The SAA and nitrogen content was controlled at the desired experimental levels by varying the amount of cystine and methionine and the non-essential amino acids L-alanine, L-aspartic acid, glycine and L-serine.
Regulation (controlled) of SAA
3) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2657829 Disease Relevance 0.06 Pain Relevance 0
Feeding of cholesterol at doses up to 0.50% w/w did not alter plasma SAA levels (Figure 4b).
Neg (not) Regulation (alter) of SAA in plasma
4) Confidence 0.19 Published 2007 Journal Genome Biol Section Body Doc Link PMC2375038 Disease Relevance 1.37 Pain Relevance 0.48
We excluded patients who had a medical or surgical illness such as recent infection, trauma and/or a neoplastic disease, in order to remove other confounding factors affecting SAA level.


Regulation (affecting) of SAA associated with cancer, injury and infection
5) Confidence 0.18 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628111 Disease Relevance 1.64 Pain Relevance 0.65
HYPOTHESIS: The study was undertaken to determine the effect of angioplasty on the levels of SAA and the correlation with postangioplasty restenosis.
Regulation (effect) of SAA
6) Confidence 0.16 Published 1998 Journal Clin Cardiol Section Body Doc Link 9755382 Disease Relevance 0.10 Pain Relevance 0
Patients with acute pancreatitis had serum concentrations of SAA, PCT, and CRP significantly higher (P < 0.001) than those of healthy subjects during the entire study period.
Regulation (concentrations) of SAA associated with pancreatitis
7) Confidence 0.08 Published 2000 Journal Dig. Dis. Sci. Section Abstract Doc Link 10877218 Disease Relevance 1.09 Pain Relevance 0.13
We have investigated the existence and possible significance of the acute-phase responses of CRP and another sensitive reactant, serum amyloid A protein (SAA), in patients with unstable or stable angina.
Regulation (responses) of SAA associated with angina and alzheimer's dementia
8) Confidence 0.07 Published 1997 Journal Lancet Section Abstract Doc Link 9040576 Disease Relevance 0.70 Pain Relevance 0.39
There were no significant differences between the pre- or postprocedure values of CRP, SAA, or IL-6 in patients with or without in-stent restenosis.
Regulation (values) of SAA
9) Confidence 0.04 Published 2004 Journal Am. Heart J. Section Body Doc Link 15199358 Disease Relevance 0.07 Pain Relevance 0
This might be one reason why we were not able to discover changes in plasma CRP, SAA, and sICAM-1.
Regulation (changes) of SAA in plasma
10) Confidence 0.03 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2762952 Disease Relevance 0.58 Pain Relevance 0.17

General Comments

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