INT68087

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Context Info
Confidence 0.39
First Reported 1997
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 9
Total Number 11
Disease Relevance 8.06
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Vwf) cell adhesion (Vwf) endoplasmic reticulum (Vwf)
proteinaceous extracellular matrix (Vwf) molecular_function (Vwf) response to stress (Vwf)
Anatomy Link Frequency
VWF 2
plasma 1
platelet 1
body 1
Vwf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 25 100.00 Very High Very High Very High
Angina 20 99.60 Very High Very High Very High
cytokine 1 94.92 High High
withdrawal 1 93.92 High High
Pain 1 87.80 High High
spinal inflammation 2 79.88 Quite High
ischemia 3 79.28 Quite High
rheumatoid arthritis 1 70.28 Quite High
alcohol 1 65.52 Quite High
cINOD 1 64.80 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 27 100.00 Very High Very High Very High
Adhesions 5 100.00 Very High Very High Very High
Acute Coronary Syndrome 5 99.96 Very High Very High Very High
Cv General 3 Under Development 20 99.60 Very High Very High Very High
Obesity 11 98.80 Very High Very High Very High
Diabetes Mellitus 56 98.60 Very High Very High Very High
Atherosclerosis 13 98.56 Very High Very High Very High
Myocardial Infarction 10 97.76 Very High Very High Very High
Cardiovascular Disease 14 95.40 Very High Very High Very High
Fever 8 89.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The improvement in VWF depended on its severity assessed by the frequency of attacks, the extent of the affected finger phalanges and the Stockholm vascular (V) stage at the start of the 1982 survey.
Regulation (depended) of VWF in VWF
1) Confidence 0.39 Published 1997 Journal Int Arch Occup Environ Health Section Abstract Doc Link 9049668 Disease Relevance 0.32 Pain Relevance 0.09
The incidence of the composite clinical efficacy end point was: 13% (enoxaparin), 19% (dalteparin), and 28% (UFH). vWF and its receptor glycoprotein Ib/IX play a key role in acute coronary syndromes. vWF is linked to inflammation and, like glycoprotein Ib/IX, is affected more favorably by the LWMHs than by UFH.
Regulation (affected) of vWF associated with acute coronary syndrome and inflammation
2) Confidence 0.34 Published 2003 Journal Am. J. Cardiol. Section Abstract Doc Link 12686329 Disease Relevance 0.80 Pain Relevance 0.34
In the group of VWF patients, seven workers had both VWF and CTS.
Regulation (had) of VWF in VWF
3) Confidence 0.24 Published 2009 Journal Int Arch Occup Environ Health Section Body Doc Link 18781317 Disease Relevance 0 Pain Relevance 0
Thus, the purpose of this study was to examine changes in plasma VWF and ADAMTS13 levels in UA patients.
Spec (examine) Regulation (changes) of VWF in plasma associated with angina
4) Confidence 0.19 Published 2008 Journal Thromb. Res. Section Abstract Doc Link 18295305 Disease Relevance 0.54 Pain Relevance 0.37
We hypothesized that the concentrations of hs-CRP and vWF are substantially increased in patients with unstable angina pectoris (UAP) and noticeably decreased following coronary stenting along with atorvastatin therapy.
Regulation (concentrations) of vWF associated with angina
5) Confidence 0.19 Published 2006 Journal International heart journal Section Abstract Doc Link 16960405 Disease Relevance 0.44 Pain Relevance 0.49
We used a series of regression models to estimate relative risks for diabetes per interquartile range (IQR) increase in PAI-1 (IQR 16.8 ng/ml) and vWF (IQR 66.8% of control) conditioned on baseline characteristics.
Regulation (control) of vWF associated with diabetes mellitus
6) Confidence 0.17 Published 2006 Journal Diabetes Section Abstract Doc Link 16443791 Disease Relevance 1.29 Pain Relevance 0.13
There was no significant treatment effect on von Willebrand factor or soluble P-selectin.
Neg (no) Regulation (effect) of von Willebrand factor
7) Confidence 0.14 Published 2001 Journal Rheumatology (Oxford) Section Body Doc Link 11561116 Disease Relevance 0 Pain Relevance 0
Thus, the mean changes in CD40L expression and vWF in our study were smaller than, but within an order of magnitude of, the increases seen in patients with clinical cardiovascular disease.
Regulation (changes) of vWF associated with cardiovascular disease
8) Confidence 0.08 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC3002188 Disease Relevance 0.75 Pain Relevance 0.15
In previous studies of healthy subjects in our laboratory (Pietropaoli et al. 2004), inhalation of elemental carbon UFP for 2 hr did not alter platelet counts or plasma levels of IL-6, vWF, fibrinogen, or factor VII.
Neg (not) Regulation (alter) of vWF in platelet
9) Confidence 0.06 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC3002188 Disease Relevance 0.26 Pain Relevance 0.03
Risk factors inclusive of plasma lipids, IL-6 (interleukin-6), CRP (C-reactive protein), vWF (von Willebrand factor), fibrin D-dimer, ICAM-1 (intercellular cell-adhesion molecule-1) and fibrinogen were measured, and blood pressure and BMI (body mass index) were determined by standard techniques.
Regulation (measured) of vWF in body associated with obesity and adhesions
10) Confidence 0.05 Published 2005 Journal Clin. Sci. Section Abstract Doc Link 15801904 Disease Relevance 0.98 Pain Relevance 0.28
The patients with IRS have higher values of fibrinogen, factor VII, VIII, Von Willebrand factor and Plasminogen Activator Inhibitor (PAI) compared to control subjects.
Regulation (values) of Von Willebrand factor
11) Confidence 0.02 Published 2009 Journal Clin. Appl. Thromb. Hemost. Section Abstract Doc Link 19033264 Disease Relevance 2.69 Pain Relevance 0.49

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