INT68091

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Context Info
Confidence 0.66
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 19
Total Number 20
Disease Relevance 9.13
Pain Relevance 2.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL1A1) extracellular region (COL1A1) cytoplasm (COL1A1)
Anatomy Link Frequency
Platelet 2
Cleavage 1
extracellular matrix 1
urine 1
COL1A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 41 99.84 Very High Very High Very High
agonist 17 99.62 Very High Very High Very High
metalloproteinase 14 99.52 Very High Very High Very High
cytokine 76 99.40 Very High Very High Very High
Inflammation 114 99.08 Very High Very High Very High
Clonidine 5 97.66 Very High Very High Very High
Osteoarthritis 155 84.56 Quite High
chemokine 19 79.80 Quite High
Endocannabinoid 48 77.04 Quite High
Tendonitis 2 74.08 Quite High
Disease Link Frequency Relevance Heat
Disease 148 99.96 Very High Very High Very High
Arthritis 39 99.84 Very High Very High Very High
Primary Sclerosing Cholangitis 242 99.20 Very High Very High Very High
INFLAMMATION 123 99.08 Very High Very High Very High
Hepatocellular Cancer 72 98.68 Very High Very High Very High
Mucocutaneous Lymph Node Syndrome 50 98.20 Very High Very High Very High
Hypercalcemia 57 96.96 Very High Very High Very High
Alpha-1-antitrypsin Deficiency 5 90.60 High High
Cancer 120 88.88 High High
Osteoarthritis 164 84.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The absence of PP and clonidine responses under these conditions may have implications for the mechanisms by which these agonists inhibit, chloride secretion in Col-1 epithelia.
Localization (secretion) of Col-1 associated with agonist and clonidine
1) Confidence 0.66 Published 1997 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9050010 Disease Relevance 0 Pain Relevance 0.53
Of the remaining 13 peptides, COL1A1-11734, COL9A2-1126, FGB1631 and UMOD1755 differentiated ND/SAF from all other inflammatory classes (KD/FI/AF); the other nine peptides did not show an obvious pattern.
Localization (differentiated) of COL1A1 associated with mucocutaneous lymph node syndrome, inflammation, disease and arthritis
2) Confidence 0.54 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 2.22 Pain Relevance 0.57
Gene expression of collagen type-II, collagen type-I, aggrecan, MMP-13, IL-6, Il-1?
Localization (aggrecan) of collagen type-I
3) Confidence 0.39 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2921357 Disease Relevance 0.11 Pain Relevance 0
In this study, we report that bortezomib used alone and in combination with a glucocorticoid as front-line treatment in previously untreated, bisphosphonate-naïve patients stimulates bone formation not only as shown by an increase in bALP but also through the use of a novel bone marker, pro-collagen type I N-terminal propeptide (PINP) that is released as collagen is deposited and becomes insoluble during the formation of the organic bone matrix (34) and may, therefore, be a better marker for ongoing bone formation.
Localization (released) of collagen type I
4) Confidence 0.35 Published 2010 Journal European Journal of Haematology Section Body Doc Link PMC2970902 Disease Relevance 0.35 Pain Relevance 0
40%, and serum C-telopeptide of type 1 collagen (CTx) ?
Localization (telopeptide) of type 1 collagen
5) Confidence 0.24 Published 2006 Journal Clinical Interventions in Aging Section Body Doc Link PMC2699644 Disease Relevance 0.12 Pain Relevance 0
Platelet concentration was positively correlated with COL1A1, ratio of COL1A1:COL3A1, and COMP, and negatively correlated with COL3A1, MMP-13, and MMP-3.
Localization (ratio) of COL1A1 in Platelet
6) Confidence 0.23 Published 2009 Journal J. Orthop. Res. Section Abstract Doc Link 19170097 Disease Relevance 0 Pain Relevance 0.11
Platelet concentration was positively correlated with COL1A1, ratio of COL1A1:COL3A1, and COMP, and negatively correlated with COL3A1, MMP-13, and MMP-3.
Localization (ratio) of COL1A1 in Platelet
7) Confidence 0.23 Published 2009 Journal J. Orthop. Res. Section Abstract Doc Link 19170097 Disease Relevance 0 Pain Relevance 0.11
The fusion protein derived from the translocation of COL1A1-PDGFB acts in the cells as fully functional PDGF-B.
Localization (translocation) of COL1A1-PDGFB
8) Confidence 0.23 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721290 Disease Relevance 0.49 Pain Relevance 0
FISH demonstrated the COL1A1-PDGF-B translocation.
Localization (translocation) of COL1A1
9) Confidence 0.23 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721290 Disease Relevance 0.54 Pain Relevance 0
In approximately 8% of DFSP the COL1A1-PDGFB fusion is not found suggesting that other genes may be involved in these cases, or that there is a cryptic rearrangement of COL1A1 or PDGFB.
Localization (rearrangement) of COL1A1
10) Confidence 0.21 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721290 Disease Relevance 0.23 Pain Relevance 0
At the same time serum and urine samples were obtained for baseline measurement of markers of bone turnover (serum BSAP and urinary excretion of cross-linked n-terminal telopeptides of type 1 collagen).
Localization (excretion) of type 1 collagen in urine
11) Confidence 0.13 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936260 Disease Relevance 0.12 Pain Relevance 0
Collagen synthesis was determined as the de novo release of the carboxy-terminal peptide fragment of collagen type I (CICP), reflecting true collagen synthesis.
Localization (release) of collagen type I
12) Confidence 0.12 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.36 Pain Relevance 0.10
Furthermore, AM215 had no effects on fibronectin and collagen 1 secretion (cell culture supernatants of cells grown to 100% confluency before initiation of treatment; immunoblots from three pooled experiments; Figure 4).
Localization (secretion) of collagen 1
13) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 0.35 Pain Relevance 0.23
From two novel proteins associated with hepatocellular carcinomas in man [5], suppressors of cytokine signaling type 3 (SOCS3) and collagen-I, a non-significant 2-fold elevation of SOCS3, were found and a 7-fold, significant down-regulation of collagen-I was observed.
Localization (regulation) of collagen-I associated with hepatocellular cancer and cytokine
14) Confidence 0.08 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC535891 Disease Relevance 0.50 Pain Relevance 0.05
From two novel proteins associated with hepatocellular carcinomas in man [5], suppressors of cytokine signaling type 3 (SOCS3) and collagen-I, a non-significant 2-fold elevation of SOCS3, were found and a 7-fold, significant down-regulation of collagen-I was observed.
Localization (regulation) of collagen-I associated with hepatocellular cancer and cytokine
15) Confidence 0.08 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC535891 Disease Relevance 0.51 Pain Relevance 0.05
Cleavage of type I collagen results in release of C-terminal telopeptide of collagen type I (CTX-I) [20,21], which has been used extensively as a surrogate measure of bone resorption for in vitro, preclinical and clinical studies [20,22].
Localization (release) of collagen type I in Cleavage associated with hypercalcemia
16) Confidence 0.08 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2902412 Disease Relevance 1.03 Pain Relevance 0.40
In a next step, the profibrogenic cytokine TGFbeta, which stimulates the synthesis and secretion of fibronectin, collagen1 and matrix metalloproteinases, was analyzed, revealing that neither AM251 nor AM630 significantly altered secreted TGFbeta levels (Figure 3E).
Localization (secretion) of collagen1 associated with metalloproteinase and cytokine
17) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 0.57 Pain Relevance 0.28
These experiments showed that both LPS and TNFalpha increased the secretion of collagen1 and fibronectin (Figure 3A).
Localization (secretion) of collagen1
18) Confidence 0.06 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 0.51 Pain Relevance 0.04
Immunoblot analysis of cell culture supernatants was used to analyze the secretion of the extracellular matrix proteins collagen1 and fibronectin by PSC.
Spec (analyze) Localization (secretion) of collagen1 in extracellular matrix associated with primary sclerosing cholangitis
19) Confidence 0.06 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 0.68 Pain Relevance 0.07
Renin, simply considered until recently as the rate-limiting enzyme of RAAS activation, has also turned out to be the ligand for a protein known as the renin/prorenin receptor (RPR), which binds renin and prorenin about equally, regardless of their biologic activities.3 Prorenin, which represents 70%–90% of total circulating renin, when bound to the RPR, induces an increase in the catalytic efficiency of angiotensinogen conversion to Ang I, which contributes to local production of Ang II and its systemic levels, as well as binding of renin/prorenin to the RPR, exerting physiologic effects that are independent of Ang II, including activation of intracellular signal pathways, enhanced synthesis of DNA, and stimulation of the release of plasminogen activator inhibitor (PAI-1), collagen-1, fibronectin, and transforming growth factor beta-1.3
Localization (release) of collagen-1
20) Confidence 0.01 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2952455 Disease Relevance 0.43 Pain Relevance 0.03

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