INT68099

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Context Info
Confidence 0.48
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 16.63
Pain Relevance 4.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Agtr2) plasma membrane (Agtr2) transcription factor binding (Agtr2)
signal transducer activity (Agtr2)
Anatomy Link Frequency
retina 2
central nervous system 2
neuronal 2
juxtaglomerular cells 1
kidney 1
Agtr2 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 45 100.00 Very High Very High Very High
beta blocker 3 100.00 Very High Very High Very High
bradykinin 2 99.98 Very High Very High Very High
Inflammation 71 99.62 Very High Very High Very High
Neuropeptide 4 99.62 Very High Very High Very High
qutenza 2 99.62 Very High Very High Very High
antinociception 8 99.44 Very High Very High Very High
Enkephalin 3 99.38 Very High Very High Very High
Antinociceptive 5 98.02 Very High Very High Very High
Central nervous system 3 97.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 29 100.00 Very High Very High Very High
Hypertension 14 100.00 Very High Very High Very High
Infection 278 99.86 Very High Very High Very High
Cytomegalovirus Infection 384 99.66 Very High Very High Very High
Diabetic Retinopathy 36 99.56 Very High Very High Very High
Diabetes Mellitus 451 99.46 Very High Very High Very High
Pneumonia 4 99.40 Very High Very High Very High
Disease 156 99.32 Very High Very High Very High
Apoptosis 6 99.32 Very High Very High Very High
Nociception 2 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We made use of targeted disruption of the mouse AT2 gene to examine the functional role of the AT2 receptor in the central nervous system (CNS).
Positive_regulation (disruption) of AT2 in central nervous system associated with targeted disruption and central nervous system
1) Confidence 0.48 Published 2000 Journal Life Sci. Section Abstract Doc Link 11104359 Disease Relevance 0.68 Pain Relevance 0.30
The importance of AT2 receptor subtype for the nociception reducing effect of AngII is considered.
Positive_regulation (importance) of AT2 receptor associated with nociception
2) Confidence 0.41 Published 1999 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9972688 Disease Relevance 0.19 Pain Relevance 0.17
We made use of targeted disruption of the mouse AT2 gene to examine the role of the AT2 receptor in the central nervous system (CNS).
Positive_regulation (disruption) of AT2 in central nervous system associated with targeted disruption and central nervous system
3) Confidence 0.38 Published 1999 Journal Brain Res. Section Abstract Doc Link 10064799 Disease Relevance 0.39 Pain Relevance 0.08
The antinociceptive action of beta-endorphin is due to spinal release of met-enkephalin which results in spinal delta 2 receptor activation.
Positive_regulation (activation) of 2 receptor in spinal associated with enkephalin and antinociceptive
4) Confidence 0.13 Published 1997 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9050081 Disease Relevance 0 Pain Relevance 1.49
Fig. 2Multiple roles of angiotensin II in the pathogenesis of chronic kidney disease.
Positive_regulation (roles) of angiotensin II in kidney associated with chronic renal failure
5) Confidence 0.08 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.88 Pain Relevance 0.24
Renin release can also be inhibited by a direct action of angiotensin II on the juxtaglomerular cells.
Positive_regulation (action) of angiotensin II in juxtaglomerular cells
6) Confidence 0.08 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.26 Pain Relevance 0
In contrast, the baseline levels of synaptophysin in PC12D cells not stimulated with angiotensin II were unaffected with these inhibitors (data not shown).


Neg (not) Positive_regulation (stimulated) of angiotensin II
7) Confidence 0.07 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.15 Pain Relevance 0
In the diabetic retina, the RAS components angiotensin II and AT1R were upregulated together with AT1R's downstream ERK activation (Fig. 1).
Positive_regulation (upregulated) of angiotensin II in retina associated with diabetes mellitus
8) Confidence 0.06 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.64 Pain Relevance 0
Angiotensin II–induced neuronal ERK activation, also observed in the diabetic retina (Fig. 1), resulted in the degradation of synaptophysin protein in vitro (Fig. 5).
Positive_regulation (activation) of Angiotensin II in neuronal associated with diabetes mellitus
9) Confidence 0.06 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.83 Pain Relevance 0
Indeed, human surgical samples from eyes with diabetic retinopathy showed a significant increase in angiotensin II levels (8–10).
Positive_regulation (increase) of angiotensin II in eyes associated with diabetic retinopathy
10) Confidence 0.06 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 1.02 Pain Relevance 0.04
In the diabetic retina, the production of angiotensin II and AT1R was upregulated, leading to ERK activation in the downstream of AT1R signaling (Fig. 1).
Positive_regulation (upregulated) of angiotensin II in retina associated with diabetes mellitus
11) Confidence 0.06 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.90 Pain Relevance 0
Additionally, an increased angiotensin II (Ang II) level was detected in mouse serum and in arterial blood vascular tissues after MCMV infection.
Positive_regulation (increased) of angiotensin II in blood associated with cytomegalovirus infection and infection
12) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 3.19 Pain Relevance 0.17
MCMV infection alone increased angiotensin II (Ang II) level in mouse serum.
Positive_regulation (increased) of angiotensin II associated with cytomegalovirus infection and infection
13) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.22 Pain Relevance 0
It also contains a brief discussion of NE and its relationship to fear-provoking stimuli followed by preclinical and clinical studies that demonstrate heightened noradrenergic neuronal reactivity, increased alpha 2 receptor sensitivity and exaggerated arousal in organisms that have been exposed to chronic uncontrollable stress.
Positive_regulation (increased) of 2 receptor in neuronal associated with stress and anxiety disorder
14) Confidence 0.06 Published 1999 Journal Biol. Psychiatry Section Abstract Doc Link 10560025 Disease Relevance 0.47 Pain Relevance 0.06
Major differences between ACE-i and valsartan are discussed including inflammation, activation of neutrophils, mode of bradykinin activation, AT2 receptor stimulation and apoptosis of smooth muscle cells.
Positive_regulation (activation) of AT2 receptor in smooth muscle cells associated with inflammation, apoptosis and bradykinin
15) Confidence 0.05 Published 2005 Journal Int. J. Cardiol. Section Abstract Doc Link 15686787 Disease Relevance 1.23 Pain Relevance 0.18
An increased sensitivity of the arteries to vasoconstrictor agents like angiotensin II (Ang II) has been described in PE.
Positive_regulation (increased) of angiotensin II associated with pre-eclampsia
16) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965104 Disease Relevance 0.45 Pain Relevance 0
-adrenergic receptor mediated inhibition of collagen synthesis was further decreased by co-activation of angiotensin II receptor suggesting the cross-talk might play a role in inhibition of fibrosis in heart.
Positive_regulation (activation) of II receptor in heart associated with fibrosis
17) Confidence 0.04 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0.10 Pain Relevance 0.05
Activation of cultured microglia with toll-like receptor 2 (TLR2), TLR4, or TLR9 ligand markedly boosted ingestion of A?
Positive_regulation (Activation) of receptor 2 in microglia
18) Confidence 0.03 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430555 Disease Relevance 1.27 Pain Relevance 0.15
Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms.
Positive_regulation (activation) of receptor-2 in lung associated with qutenza, inflammation, neuropeptide and pneumonia
19) Confidence 0.02 Published 2005 Journal J. Immunol. Section Title Doc Link 16081834 Disease Relevance 0.40 Pain Relevance 0.60
Several clinical trials have demonstrated that AT-II-receptor antagonists are as effective as calcium-channel blockers, beta-blockers, and ACE inhibitors in the treatment of hypertension and induce fewer adverse effects.
Positive_regulation (induce) of AT-II-receptor associated with beta blocker, antagonist and hypertension
20) Confidence 0.02 Published 2000 Journal Am J Health Syst Pharm Section Abstract Doc Link 10902066 Disease Relevance 0.64 Pain Relevance 0.51

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