INT6810

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Context Info
Confidence 0.78
First Reported 1985
Last Reported 2010
Negated 10
Speculated 1
Reported most in Abstract
Documents 70
Total Number 72
Disease Relevance 54.80
Pain Relevance 8.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ENO2) small molecule metabolic process (ENO2) lyase activity (ENO2)
plasma membrane (ENO2) intracellular (ENO2) carbohydrate metabolic process (ENO2)
Anatomy Link Frequency
neuron 35
parathyroid 2
neuronal 2
brain 1
nucleus 1
ENO2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 229 100.00 Very High Very High Very High
Neuropeptide 28 100.00 Very High Very High Very High
Enkephalin 15 100.00 Very High Very High Very High
substance P 14 100.00 Very High Very High Very High
Serotonin 10 100.00 Very High Very High Very High
calcitonin gene related peptide 1 100.00 Very High Very High Very High
Pain 24 99.84 Very High Very High Very High
agonist 45 98.68 Very High Very High Very High
Cholecystokinin 2 97.92 Very High Very High Very High
Electroencephalography 77 97.42 Very High Very High Very High
Disease Link Frequency Relevance Heat
Exanthema 4 99.96 Very High Very High Very High
Cancer 494 99.88 Very High Very High Very High
Pain 22 99.84 Very High Very High Very High
Metastasis 92 99.76 Very High Very High Very High
Hypothermia 1821 99.68 Very High Very High Very High
Brain Injury 32 99.20 Very High Very High Very High
Coma 30 99.20 Very High Very High Very High
Status Epilepticus 30 99.00 Very High Very High Very High
Empyema Thoracis 3 98.72 Very High Very High Very High
Malignant Neoplastic Disease 98 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Population of cells expressing neuron-specific enolase, synaptophysin, and chromogranin A, which were stained by paraldehyde-fuchsin, was demonstrated in subodontoblastic layer of the dental pulp.
Gene_expression (expressing) of neuron-specific enolase in dental pulp
1) Confidence 0.78 Published 2007 Journal Morfologiia Section Abstract Doc Link 17722571 Disease Relevance 0 Pain Relevance 0.08
A significant higher proportion of patients with good neurological outcome (CPC 1 to 2) was observed for NSE levels in the range of 20 to 40 ?
Gene_expression (levels) of NSE
2) Confidence 0.78 Published 2010 Journal Crit Care Section Body Doc Link PMC2887191 Disease Relevance 1.11 Pain Relevance 0
Immunohistological examinations of various hormones and of neurone-specific enolase were negative, but repeatedly measured high serum levels of pancreatic polypeptide and of beta-HCG nonetheless suggested an endocrine tumour.
Neg (negative) Gene_expression (negative) of neurone-specific enolase associated with cancer
3) Confidence 0.75 Published 1987 Journal Dtsch. Med. Wochenschr. Section Abstract Doc Link 3319478 Disease Relevance 0.77 Pain Relevance 0.21
Expression of neuron-specific enolase, Leu-7, and neuropeptides in human fetal salivary gland epithelium.
Gene_expression (Expression) of neuron-specific enolase in salivary gland epithelium associated with neuropeptide
4) Confidence 0.75 Published 1989 Journal J. Histochem. Cytochem. Section Title Doc Link 2471726 Disease Relevance 0.06 Pain Relevance 0.47
Immunohistochemically co-expression of cytokeratin, vimentin, desmin, and NSE was observed.
Gene_expression (co-expression) of NSE
5) Confidence 0.75 Published 2002 Journal Lung Cancer Section Abstract Doc Link 12009247 Disease Relevance 0.54 Pain Relevance 0.14
Biopsy samples from eutopic endometrium were used for immunohistochemical staining to detect synaptophysin (SYN) and neuron-specific enolase (NSE) expression in women with and without endometriosis.
Gene_expression (expression) of NSE in neuron
6) Confidence 0.75 Published 2010 Journal Hum. Reprod. Section Body Doc Link 19910323 Disease Relevance 0 Pain Relevance 0
Immunohistochemical staining showed that the cells expressed neuroendocrine markers (synaptophysin, chromogranin, NSE) and cytokeratin marker (CAM 5.2) but were negative for S100, HMB45, CD99 and CD117.
Gene_expression (expressed) of NSE
7) Confidence 0.75 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1971059 Disease Relevance 0.77 Pain Relevance 0.07
Neuron specific enolase (NSE), c-Fos, vasoactive intestinal peptide (VIP) and substance P (SP) were detected using immunohistochemical methods.
Gene_expression (detected) of NSE in Neuron associated with substance p
8) Confidence 0.75 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16828227 Disease Relevance 0 Pain Relevance 0.23
Immunocytochemical study demonstrated the presence of neuron-specific enolase, Leu 7 antigen, chromogranin, epithelial membrane antigen, and vasoactive intestinal polypeptide within tumor cells.
Gene_expression (presence) of neuron-specific enolase in neuron associated with cancer
9) Confidence 0.68 Published 1986 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 3006628 Disease Relevance 0.60 Pain Relevance 0.08
In our analysis, NSE levels were not blinded to the physicians in charge.
Gene_expression (levels) of NSE
10) Confidence 0.67 Published 2010 Journal Crit Care Section Body Doc Link PMC2887191 Disease Relevance 0.52 Pain Relevance 0.05
g/l hypothermia treatment is associated with a lower probability of unfavorable neurological outcome (CPC 3 to 5) compared to the NH group whereas in the range of NSE levels >100 ?
Gene_expression (levels) of NSE associated with hypothermia
11) Confidence 0.67 Published 2010 Journal Crit Care Section Body Doc Link PMC2887191 Disease Relevance 1.14 Pain Relevance 0
g/l (P < 0.001) as well as in the group of patients with NSE levels in the range of 40 to 80 ?
Gene_expression (levels) of NSE
12) Confidence 0.67 Published 2010 Journal Crit Care Section Body Doc Link PMC2887191 Disease Relevance 1.06 Pain Relevance 0
According to our results, patients treated with hypothermia stand a good chance of recovery despite higher levels of NSE.
Gene_expression (levels) of NSE associated with hypothermia
13) Confidence 0.67 Published 2010 Journal Crit Care Section Body Doc Link PMC2887191 Disease Relevance 0.89 Pain Relevance 0.04
In the large Prognosis in Postanoxic Coma Study Group (PROPAC) all patients with NSE levels >33 ?
Gene_expression (levels) of NSE associated with coma
14) Confidence 0.67 Published 2010 Journal Crit Care Section Body Doc Link PMC2887191 Disease Relevance 1.05 Pain Relevance 0
Neuron specific enolase (NSE), c-Fos, vasoactive intestinal peptide (VIP) and substance P (SP) were detected using immunohistochemical methods.
Gene_expression (detected) of enolase in Neuron associated with substance p
15) Confidence 0.65 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16828227 Disease Relevance 0 Pain Relevance 0.23
Positive CgA, Syn, NSE staining was diffuse cytoplasmic brown granules, while positive S-100 staining was in the nucleus and the cytoplasm.[1]

RESULTS

Gene_expression (staining) of NSE in nucleus
16) Confidence 0.65 Published 2010 Journal Urology Annals Section Body Doc Link PMC2934586 Disease Relevance 1.35 Pain Relevance 0.27
Immunohistochemically, neoplastic cells diffusely stained with anti-vimentin antibodies and were focally positive for chromogranin A, neuron-specific enolase, lysozyme, and cytokeratins AE1/AE3.
Gene_expression (positive) of neuron-specific enolase in neuron
17) Confidence 0.65 Published 2001 Journal Ultrastruct Pathol Section Abstract Doc Link 11297323 Disease Relevance 1.05 Pain Relevance 0.13
Paraffin-embedded sections of 99 human adrenal and extraadrenal paragangliomas were analyzed by the indirect immunoperoxidase technique for the presence of neuron-specific enolase (NSE) and 10 neuropeptides.
Gene_expression (presence) of neuron-specific enolase in neuron associated with neuropeptide and paraganglioma
18) Confidence 0.62 Published 1988 Journal Hum. Pathol. Section Abstract Doc Link 2447010 Disease Relevance 0.51 Pain Relevance 0.38
Paraffin-embedded sections of 99 human adrenal and extraadrenal paragangliomas were analyzed by the indirect immunoperoxidase technique for the presence of neuron-specific enolase (NSE) and 10 neuropeptides.
Gene_expression (presence) of NSE in neuron associated with neuropeptide and paraganglioma
19) Confidence 0.62 Published 1988 Journal Hum. Pathol. Section Abstract Doc Link 2447010 Disease Relevance 0.51 Pain Relevance 0.38
NSE and Leu-7 immunoreactivity in the fetal salivary gland epithelium was observed solitarily or in groups commonly restricted to the developing duct epithelium.
Gene_expression (immunoreactivity) of NSE in epithelium
20) Confidence 0.61 Published 1989 Journal J. Histochem. Cytochem. Section Abstract Doc Link 2471726 Disease Relevance 0.08 Pain Relevance 0.46

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