INT68165

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Context Info
Confidence 0.01
First Reported 1996
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.63
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Alox5, Pdpk1) nucleus (Alox5, Pdpk1) cytoplasm (Alox5, Pdpk1)
nuclear envelope (Alox5) oxidoreductase activity (Alox5) cytoplasmic membrane-bounded vesicle (Pdpk1)
Alox5 (Rattus norvegicus)
Pdpk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 4 100.00 Very High Very High Very High
Thermal hyperalgesia 15 99.02 Very High Very High Very High
nMDA receptor 5 94.72 High High
Glutamate receptor 1 94.28 High High
Hyperalgesia 1 74.12 Quite High
intrathecal 6 65.68 Quite High
antagonist 3 37.64 Quite Low
excitatory amino acid 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Hyperalgesia 16 99.02 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The thermal hyperalgesia produced by N-methyl-D-aspartate is mediated by activation of nitric oxide synthase and protein kinase C, but not by phospholipase C, phospholipase A2, cyclo-oxygenase or lipoxygenase.
lipoxygenase Positive_regulation (activation) of protein kinase associated with kinase c and thermal hyperalgesia
1) Confidence 0.01 Published 1996 Journal Neuroscience Section Abstract Doc Link 9053788 Disease Relevance 0.63 Pain Relevance 1.12

General Comments

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