INT68179

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Context Info
Confidence 0.78
First Reported 1997
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 8.87
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Nf1) signal transduction (Nf1) nucleus (Nf1)
intracellular (Nf1) extracellular matrix organization (Nf1) protein complex (Nf1)
Anatomy Link Frequency
neuronal 1
bone marrow 1
Nf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Lasting pain 1 97.80 Very High Very High Very High
Pain 5 93.04 High High
depression 1 77.76 Quite High
Neuropeptide 5 75.00 Quite High
qutenza 5 71.92 Quite High
addiction 4 67.40 Quite High
substance P 2 67.28 Quite High
Calcitonin gene-related peptide 4 66.00 Quite High
headache 3 64.56 Quite High
Action potential 2 47.52 Quite Low
Disease Link Frequency Relevance Heat
Watson Syndrome 119 100.00 Very High Very High Very High
Shock 6 99.82 Very High Very High Very High
Osteoporosis 2 99.76 Very High Very High Very High
Cancer 246 99.12 Very High Very High Very High
Pain 3 97.80 Very High Very High Very High
Cognitive Disorder 58 96.72 Very High Very High Very High
Malignant Neoplastic Disease 14 95.56 Very High Very High Very High
Congenital Anomalies 5 95.44 Very High Very High Very High
Injury 2 94.76 High High
Disease 10 92.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The NF1 gene is expressed in chondrocytes, as well as osteoblasts, osteoclasts, and periosteal cells, and the Ras signaling pathway is hyperactive in these cells and in bone marrow-derived osteoprogenitors in Nf1 +/- mice [13,14].
Gene_expression (expressed) of NF1 in bone marrow associated with watson syndrome
1) Confidence 0.78 Published 2008 Journal BMC Med Section Body Doc Link PMC2531128 Disease Relevance 1.48 Pain Relevance 0.05
First, the expression of the Nf1 gene is largely restricted to neuronal tissues in the adult.
Gene_expression (expression) of Nf1 in neuronal
2) Confidence 0.78 Published 1997 Journal Nat. Genet. Section Abstract Doc Link 9054942 Disease Relevance 1.19 Pain Relevance 0.04
The NF1 gene encodes a ubiquitously expressed cytoplasmic protein called neurofibromin.
Gene_expression (expressed) of neurofibromin associated with watson syndrome
3) Confidence 0.77 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1434756 Disease Relevance 1.72 Pain Relevance 0.06
NF1 results from a heterozygous mutation of the NF1 gene, leading to decreased levels of neurofibromin, the protein product of the NF1 gene.
Gene_expression (product) of NF1 associated with watson syndrome
4) Confidence 0.67 Published 2005 Journal J. Neurophysiol. Section Abstract Doc Link 16093333 Disease Relevance 0.83 Pain Relevance 0.16
Neurofibrinomin, the protein product of the NF1 gene (neurofibromin gene (human)), is a guanosine triphosphate activating protein for p21(ras).
Gene_expression (product) of NF1 gene
5) Confidence 0.60 Published 2006 Journal Neuroscience Section Abstract Doc Link 16298082 Disease Relevance 0.45 Pain Relevance 0.29
Heat-shock induced neurofibromin was expressed in adult NF1-/- fruit flies, rescuing the learning deficits, indicating that developmental factors are not causing the cognitive deficits [10].
Gene_expression (expressed) of neurofibromin associated with cognitive disorder, shock and watson syndrome
6) Confidence 0.60 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1434756 Disease Relevance 0.80 Pain Relevance 0
mice, presumably by inactivating Nf1 gene expression as a myeloid lineage tumor suppressor gene.
Gene_expression (expression) of Nf1 associated with cancer
7) Confidence 0.59 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.82 Pain Relevance 0.03
Heat-shock induced neurofibromin was expressed in adult NF1-/- fruit flies, rescuing the learning deficits, indicating that developmental factors are not causing the cognitive deficits [10].
Gene_expression (expressed) of NF1 associated with cognitive disorder, shock and watson syndrome
8) Confidence 0.58 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1434756 Disease Relevance 0.75 Pain Relevance 0
These results suggest that MMR deficiency can accelerate myeloid leukemogenesis in Nf1+/?
Gene_expression (/) of Nf1
9) Confidence 0.45 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1361617 Disease Relevance 0.81 Pain Relevance 0.03

General Comments

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