INT68180

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Context Info
Confidence 0.27
First Reported 1997
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 2.02
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Nf1) signal transduction (Nf1) nucleus (Nf1)
intracellular (Nf1) extracellular matrix organization (Nf1) protein complex (Nf1)
Nf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 8 92.32 High High
dopamine receptor 8 82.00 Quite High
gABA 7 64.72 Quite High
depression 1 60.08 Quite High
Neurobehavioral 1 51.72 Quite High
Pain 1 25.00 Low Low
long-term potentiation 5 5.00 Very Low Very Low Very Low
Dopamine 2 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
nMDA receptor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurofibromatosis 2 100.00 Very High Very High Very High
Neurological Disease 1 100.00 Very High Very High Very High
Cancer 2 92.40 High High
Syndrome 1 91.84 High High
Neurofibroma 2 89.44 High High
Alzheimer's Dementia 3 88.24 High High
Pigment Disorder 1 88.24 High High
Hamartoma 1 85.28 High High
Glioma 2 77.44 Quite High
Pathologic Dilatation 1 76.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Network analysis identified links between neurofibromin and kinesin genes, which were down regulated in the Nf1+/- mice at postnatal days 15 and 20.


Regulation (regulated) of neurofibromin
1) Confidence 0.27 Published 2006 Journal BMC Neurosci Section Abstract Doc Link PMC1434756 Disease Relevance 0.82 Pain Relevance 0.19
Neurofibromatosis type I (NF1) is one of the most commonly inherited neurological disorders in humans, affecting approximately one in 4,000 individuals.
Regulation (affecting) of Neurofibromatosis type I associated with neurological disease and neurofibromatosis
2) Confidence 0.24 Published 1997 Journal Nat. Genet. Section Abstract Doc Link 9054942 Disease Relevance 1.20 Pain Relevance 0.03

General Comments

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