INT68181

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Context Info
Confidence 0.48
First Reported 1997
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 12
Disease Relevance 8.14
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Nf1) signal transduction (Nf1) nucleus (Nf1)
intracellular (Nf1) extracellular matrix organization (Nf1) protein complex (Nf1)
Anatomy Link Frequency
NF-1 3
neurons 1
melanocytes 1
Nf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 6 99.46 Very High Very High Very High
dopamine receptor 56 99.24 Very High Very High Very High
long-term potentiation 35 93.20 High High
gABA 49 89.96 High High
Nerve growth factor 1 85.28 High High
nMDA receptor 7 83.00 Quite High
Action potential 2 78.96 Quite High
Dopamine 14 78.32 Quite High
imagery 10 76.56 Quite High
depression 1 75.48 Quite High
Disease Link Frequency Relevance Heat
Watson Syndrome 204 100.00 Very High Very High Very High
Melanoma 90 100.00 Very High Very High Very High
Neurofibromatosis 23 100.00 Very High Very High Very High
Cognitive Disorder 128 99.80 Very High Very High Very High
Alzheimer's Dementia 21 98.12 Very High Very High Very High
Neurological Disease 1 97.16 Very High Very High Very High
Nociception 1 96.16 Very High Very High Very High
Disease 17 95.76 Very High Very High Very High
Cancer 48 95.32 Very High Very High Very High
Neurofibroma 65 92.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Current literature has identified physical interactions between NF1, APP, and kinesin-1 integral to vesicle transport in melanocytes and neurons.
NF1 Binding (interactions) of in neurons associated with watson syndrome
1) Confidence 0.48 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1434756 Disease Relevance 0.41 Pain Relevance 0.19
Interaction between neurofibromin and kinesins suggests a mechanism for intracellular localization of the neurofibromin/APP complex.
neurofibromin Binding (Interaction) of
2) Confidence 0.48 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1434756 Disease Relevance 0.48 Pain Relevance 0.13
A mouse model of the cognitive deficits associated with Neurofibromatosis type 1 was first developed in 1994 and has since been utilized in the investigation and characterization of the disease [11,12].
Neurofibromatosis type 1 Binding (associated) of associated with cognitive disorder, disease and watson syndrome
3) Confidence 0.42 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1434756 Disease Relevance 1.04 Pain Relevance 0.21
This increased excitability may explain the painful conditions experienced by people with NF1.
NF1 Binding (people) of associated with pain and watson syndrome
4) Confidence 0.37 Published 2005 Journal J. Neurophysiol. Section Abstract Doc Link 16093333 Disease Relevance 0.25 Pain Relevance 0.28
These potential interactions between neurofibromin and APP or DRD3 might lead to new ideas about how neurofibromin is involved in cellular signaling and synaptic plasticity.
neurofibromin Binding (interactions) of
5) Confidence 0.37 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1434756 Disease Relevance 0.38 Pain Relevance 0.31
The networking program also identified neurofibromin as a physical binding partner with both the kinesin heavy chain and amyloid beta precursor protein (APP) (Fig. 2).
neurofibromin Binding (binding) of associated with alzheimer's dementia
6) Confidence 0.37 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1434756 Disease Relevance 0.10 Pain Relevance 0.15
Our case provides another framework for the discussion of the potential association between NF-1 and malignant melanoma.
NF-1 Binding (association) of in NF-1 associated with melanoma
7) Confidence 0.36 Published 2004 Journal World J Surg Oncol Section Body Doc Link PMC519028 Disease Relevance 1.19 Pain Relevance 0
This network analysis identified direct interactions between NF1, APP, integrins, filamins, and kinesins.
NF1 Binding (interactions) of associated with watson syndrome
8) Confidence 0.36 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1434756 Disease Relevance 0.32 Pain Relevance 0.15
A mouse model for the learning and memory deficits associated with neurofibromatosis type I.
neurofibromatosis type I Binding (associated) of associated with pain and neurofibromatosis
9) Confidence 0.31 Published 1997 Journal Nat. Genet. Section Title Doc Link 9054942 Disease Relevance 1.43 Pain Relevance 0.14
More importantly, the absence of NF-1 in our patient may have implications for the potential association between malignant melanoma and NF-1.


NF-1 Binding (association) of in NF-1 associated with melanoma
10) Confidence 0.27 Published 2004 Journal World J Surg Oncol Section Body Doc Link PMC519028 Disease Relevance 1.23 Pain Relevance 0.12
The potential association between NF-1 and malignant melanoma has been the source of controversy in the medical literature.
NF-1 Binding (association) of in NF-1 associated with melanoma
11) Confidence 0.27 Published 2004 Journal World J Surg Oncol Section Body Doc Link PMC519028 Disease Relevance 0.89 Pain Relevance 0
Current literature has identified physical interactions between NF1, APP, and kinesin-1 integral to vesicle transport in melanocytes and neurons.
NF1 Binding (interactions) of in melanocytes associated with watson syndrome
12) Confidence 0.16 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1434756 Disease Relevance 0.41 Pain Relevance 0.19

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