INT68187

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Context Info
Confidence 0.67
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 10.22
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TNNT2) ATPase activity (TNNT2)
Anatomy Link Frequency
skeletal muscle 3
blood 2
myocyte 1
cardiac muscle 1
TNNT2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 130 98.92 Very High Very High Very High
Inflammation 142 90.20 High High
metalloproteinase 16 87.20 High High
ischemia 74 40.96 Quite Low
isoflurane 4 40.08 Quite Low
anesthesia 2 39.20 Quite Low
vincristine 2 14.52 Low Low
Catecholamine 6 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Natriuresis 38 100.00 Very High Very High Very High
Acute Coronary Syndrome 210 99.80 Very High Very High Very High
Disease 163 99.64 Very High Very High Very High
Injury 160 99.28 Very High Very High Very High
Cv General 3 Under Development 8 98.92 Very High Very High Very High
Muscle Disease 6 98.52 Very High Very High Very High
Heart Injuries 3 98.44 Very High Very High Very High
Renal Failure 15 98.28 Very High Very High Very High
Sepsis 48 97.48 Very High Very High Very High
Angina 124 97.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the neonates on the PICU cTnT levels for only 5/22 were undetectable compared with 17/25 undetectable results in the 25 older infants (p = 0.003 using Fisher's exact test).
Gene_expression (levels) of cTnT
1) Confidence 0.67 Published 2006 Journal Crit Care Section Body Doc Link PMC1751080 Disease Relevance 0.05 Pain Relevance 0
There was, however, no significant difference between the age of controls and infants beyond the neonatal period on the PICU with their significantly higher cTnT levels.
Gene_expression (levels) of cTnT
2) Confidence 0.67 Published 2006 Journal Crit Care Section Body Doc Link PMC1751080 Disease Relevance 0.42 Pain Relevance 0.06
The older paediatric intensive care admissions' levels of cTnT were statistically significantly higher than the control population (p = 0.006; Figure 1).
Gene_expression (levels) of cTnT
3) Confidence 0.67 Published 2006 Journal Crit Care Section Body Doc Link PMC1751080 Disease Relevance 0.29 Pain Relevance 0
It is possible that these four children with high cTnT levels would have had poor end organ oxygenation leading to diffuse myocardial injury.
Gene_expression (levels) of cTnT associated with injury
4) Confidence 0.67 Published 2006 Journal Crit Care Section Body Doc Link PMC1751080 Disease Relevance 1.12 Pain Relevance 0.06
There was no correlation between the PIM score and the cTnT levels in the neonates (r = 0.27, p = 0.22).
Gene_expression (levels) of cTnT
5) Confidence 0.67 Published 2006 Journal Crit Care Section Body Doc Link PMC1751080 Disease Relevance 0 Pain Relevance 0
Patients were assessed on admission for clinical characteristics, electrocardiographic findings, renal function, cardiac troponin T (cTnT), markers of myocyte injury (heart fatty acid-binding protein [H-FABP] and glycogen phosphorylase BB), neurohormonal activation (N-terminal-pro-brain natriuretic peptide [NT-pro-BNP]), hemostatic activity (fibrinogen and D-dimer), and vascular inflammation (high-sensitivity C-reactive protein, myeloperoxidase, matrix metalloproteinase-9, pregnancy-associated plasma protein-A, and soluble CD40 ligand).
Gene_expression (admission) of cTnT in myocyte associated with natriuresis, inflammation, injury, metalloproteinase and vasculitis
6) Confidence 0.65 Published 2009 Journal Am. J. Cardiol. Section Abstract Doc Link 19101224 Disease Relevance 0.78 Pain Relevance 0.35
Bodor and colleagues [19] demonstrated expression of cTnT in foetal skeletal muscle up to 20 weeks of gestation.
Gene_expression (expression) of cTnT in skeletal muscle
7) Confidence 0.60 Published 2006 Journal Crit Care Section Body Doc Link PMC1751080 Disease Relevance 0.57 Pain Relevance 0
There was a significant positive correlation (r = 0.41, p = 0.004) between PIM score and cTnT levels.
Gene_expression (levels) of cTnT
8) Confidence 0.60 Published 2006 Journal Crit Care Section Abstract Doc Link PMC1751080 Disease Relevance 0.44 Pain Relevance 0
By contrast, the regulatory proteins troponin I and troponin T are expressed in three different isoforms: one for slow-twitch skeletal muscle fibers, one for fast-twitch skeletal muscle fibers, and one for cardiac muscle (cTnI, cTnT); cardiac-specific cTnI and cTnT assays are already available for routine use. cTnT and cTnI are the most promising markers for risk stratification in patients with unstable angina pectoris.
Gene_expression (expressed) of cTnT in cardiac muscle associated with angina
9) Confidence 0.59 Published 1997 Journal Crit Rev Clin Lab Sci Section Abstract Doc Link 9055056 Disease Relevance 0.98 Pain Relevance 0.35
There was a statistically significant correlation between the PIM score and cTnT (r = 0.41, p = 0.004).
Gene_expression (score) of cTnT
10) Confidence 0.59 Published 2006 Journal Crit Care Section Body Doc Link PMC1751080 Disease Relevance 0.38 Pain Relevance 0
There was a significant correlation between the cTnT levels and the disease severity score, but this did not persist when age and weight were corrected for.
Gene_expression (levels) of cTnT associated with disease
11) Confidence 0.59 Published 2006 Journal Crit Care Section Body Doc Link PMC1751080 Disease Relevance 0.52 Pain Relevance 0
In the 25 older paediatric intensive care admissions, the correlation between the PIM score and cTnT remained significant (r = 0.44, p = 0.028).
Gene_expression (score) of cTnT
12) Confidence 0.59 Published 2006 Journal Crit Care Section Body Doc Link PMC1751080 Disease Relevance 0 Pain Relevance 0
In spite of the possible reexpression of cTnT in human skeletal muscles, and of the lack of standardization of cTnI assays, Tn subunits are not far to meet the criteria of ideal markers for acute myocardial injury.
Gene_expression (reexpression) of cTnT in skeletal muscles associated with injury
13) Confidence 0.57 Published 1999 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 10094373 Disease Relevance 0.44 Pain Relevance 0.10
Levels of cTnT did not alter significantly following admission.
Gene_expression (Levels) of cTnT
14) Confidence 0.53 Published 2006 Journal Crit Care Section Body Doc Link PMC1751080 Disease Relevance 0.95 Pain Relevance 0.08
In most of our healthy infants under one year old cTnT was undetectable and this is in keeping with other studies [15].


Gene_expression (undetectable) of cTnT
15) Confidence 0.53 Published 2006 Journal Crit Care Section Body Doc Link PMC1751080 Disease Relevance 0.54 Pain Relevance 0.07
Recent reports on increased cTnT in patients with renal failure or myopathy without evidence of myocardial injury and undetectable cTnI suggest that cTnT could be reexpressed similar to CKMB and LDH-1 in chronically damaged human skeletal muscle.
Gene_expression (reexpressed) of cTnT in skeletal muscle associated with renal failure, injury and muscle disease
16) Confidence 0.52 Published 1997 Journal Crit Rev Clin Lab Sci Section Abstract Doc Link 9055056 Disease Relevance 1.02 Pain Relevance 0.37
The samples were analysed for cardiac troponin T (cTnT), the mass concentration of creatine kinase-MB (CK-MB mass), atrial natriuretic peptide (ANP) and the N-terminal propeptide of B-type natriuretic peptide (NT-proBNP).
Gene_expression (propeptide) of cTnT associated with natriuresis
17) Confidence 0.40 Published 2008 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2515587 Disease Relevance 0.20 Pain Relevance 0
In a retrospective analysis, Hamm (Hamm CW et al. 1999) segregated patients in two groups by the presence or absence of increased plasmatic levels of cTnT and demonstrated that only individuals with increased levels of cTnT benefit from abciximab therapy, with substantially reduced events rate both at 30 days and at 6 months.
Gene_expression (levels) of cTnT
18) Confidence 0.12 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 0.37 Pain Relevance 0.07
To date, cTnT and cTnI release has not been attributed to a tissue source other than myocardium, and except for rare analytical false positives, detection of cTnT or cTnI in the blood is indicative of heart injury (Jaffe AS, 2001).
Gene_expression (detection) of cTnT in blood associated with heart injuries
19) Confidence 0.12 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 0.18 Pain Relevance 0
However, in these studies low sensitivity troponins were used, therefore reducing cTnT sensitivity for ACS.
Gene_expression (sensitivity) of cTnT associated with acute coronary syndrome
20) Confidence 0.12 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 0.67 Pain Relevance 0.08

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