INT682

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Context Info
Confidence 0.59
First Reported 1975
Last Reported 2011
Negated 5
Speculated 1
Reported most in Abstract
Documents 97
Total Number 98
Disease Relevance 50.67
Pain Relevance 23.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (AVP) cell-cell signaling (AVP) response to stress (AVP)
signal transducer activity (AVP) cytosol (AVP) extracellular space (AVP)
Anatomy Link Frequency
plasma 18
blood 7
uterine 4
thyroid 3
hypothalamus 2
AVP (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 138 100.00 Very High Very High Very High
noradrenaline 133 100.00 Very High Very High Very High
Dismenorea 66 100.00 Very High Very High Very High
alcohol 42 100.00 Very High Very High Very High
opiate 24 100.00 Very High Very High Very High
Dynorphin 20 100.00 Very High Very High Very High
Somatostatin 8 99.98 Very High Very High Very High
Enkephalin 13 99.96 Very High Very High Very High
addiction 5 99.92 Very High Very High Very High
narcan 23 99.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyponatremia 284 100.00 Very High Very High Very High
Stress 221 100.00 Very High Very High Very High
Dysmenorrhea 27 100.00 Very High Very High Very High
Galactorrhea 20 100.00 Very High Very High Very High
Helicobacter Infection 15 100.00 Very High Very High Very High
Weight Loss 5 100.00 Very High Very High Very High
Hypothermia 4 100.00 Very High Very High Very High
Syndrome 78 99.92 Very High Very High Very High
Hyperaldosteronism 1 99.86 Very High Very High Very High
Cv General 2 Under Development 369 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This "protective barrier" against the systemic effects of ethanol disappears after gastrectomy and is partly lost in the alcoholic because of accelerated gastric emptying and decreased gastric ADH activity, respectively.
Negative_regulation (decreased) of ADH
1) Confidence 0.59 Published 1994 Journal Alcohol Alcohol Suppl Section Abstract Doc Link 8974331 Disease Relevance 0 Pain Relevance 0.16
The effect of vasopressin was inhibited by prior administration of D(CH2)5Tyr(Me)2-Arg8-Vasopressin antagonist [10(-7) M].
Negative_regulation (inhibited) of vasopressin associated with antagonist
2) Confidence 0.58 Published 2004 Journal Pharmacol. Res. Section Abstract Doc Link 15501701 Disease Relevance 0.15 Pain Relevance 0.17
Some of the pharmacological and clinical data suggest that vasopressin function is diminished in depression and augmented in mania; sometimes, however, alterations in vasopressin function may be detectable only during crucial periods of the manic-depressive cycle.
Negative_regulation (diminished) of vasopressin associated with manic depressive disorder and depression
3) Confidence 0.58 Published 1978 Journal Lancet Section Abstract Doc Link 77997 Disease Relevance 0.52 Pain Relevance 0.26
Naloxone both reduced resting levels of vasopressin and inhibited the rise in vasopressin induced by an orthostatic stimulus.
Negative_regulation (inhibited) of vasopressin associated with narcan
4) Confidence 0.58 Published 1980 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7358835 Disease Relevance 0 Pain Relevance 0.51
Naloxone both reduced resting levels of vasopressin and inhibited the rise in vasopressin induced by an orthostatic stimulus.
Negative_regulation (reduced) of vasopressin associated with narcan
5) Confidence 0.58 Published 1980 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7358835 Disease Relevance 0 Pain Relevance 0.51
Upright posture and hypertonic challenge augmented, while hypotonic saline reduced plasma vasopressin levels with no difference between the two groups.
Negative_regulation (reduced) of vasopressin in plasma
6) Confidence 0.58 Published 2003 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 14514019 Disease Relevance 0.38 Pain Relevance 0.08
Moreover, plasma ADH was still not sufficiently suppressed by acute water loading in the supine position, but plasma ANP markedly increased, thereby resulting in urinary dilution and natriuresis.
Neg (not) Negative_regulation (suppressed) of ADH in plasma associated with natriuresis
7) Confidence 0.58 Published 1991 Journal Endocrinol. Jpn. Section Abstract Doc Link 1794339 Disease Relevance 1.31 Pain Relevance 0.10
Before treatment with 0.9% saline infusion, plasma vasopressin (AVP) was not suppressed sufficiently by lowering the plasma osmolality (Posm) with an oral water load (WL), but it normally responded to a rise in Posm due to hypertonic saline infusion.
Neg (not) Negative_regulation (suppressed) of vasopressin in plasma
8) Confidence 0.58 Published 1992 Journal Endocrinol. Jpn. Section Abstract Doc Link 1535041 Disease Relevance 0.97 Pain Relevance 0.08
Before treatment with 0.9% saline infusion, plasma vasopressin (AVP) was not suppressed sufficiently by lowering the plasma osmolality (Posm) with an oral water load (WL), but it normally responded to a rise in Posm due to hypertonic saline infusion.
Neg (not) Negative_regulation (suppressed) of AVP in plasma
9) Confidence 0.58 Published 1992 Journal Endocrinol. Jpn. Section Abstract Doc Link 1535041 Disease Relevance 0.96 Pain Relevance 0.08
At diagnosis, headache and visual disturbances occurred in 63 and 58 patients, respectively, while deficiency of GH, TSH, ACTH, FSH, LH and ADH was documented in 55, 7, 19 47 and 6 patients, respectively.
Negative_regulation (deficiency) of ADH associated with headache
10) Confidence 0.57 Published 1998 Journal J. Endocrinol. Invest. Section Abstract Doc Link 9648049 Disease Relevance 0.74 Pain Relevance 0.10
Urine output and serum electrolyte concentrations were carefully monitored during surgery because of the impaired ADH response.
Negative_regulation (impaired) of ADH in Urine
11) Confidence 0.57 Published 1998 Journal Masui Section Abstract Doc Link 9785790 Disease Relevance 0.82 Pain Relevance 0.26
Inhibition of gastric alcohol dehydrogenase (ADH) has been shown to enhance alcohol absorption in man under certain circumstances.
Negative_regulation (Inhibition) of ADH associated with alcohol
12) Confidence 0.57 Published 1991 Journal Am. J. Gastroenterol. Section Abstract Doc Link 1683743 Disease Relevance 0 Pain Relevance 0.36
Metkephamid acetate, a newly synthetized analogue of methionine enkephalin, suppressed plasma vasopressin levels from 2.4 pg/ml to 0.8 pg/ml after intramuscular administration to 4 normal human volunteers.
Negative_regulation (suppressed) of vasopressin in plasma associated with enkephalin
13) Confidence 0.56 Published 1982 Journal Peptides Section Abstract Doc Link 7099985 Disease Relevance 0 Pain Relevance 0.33
More recently, a new class of drugs, introduced as “aquaretics,” has gained great attention among clinicians because of its ability to correct hyponatremia via direct competitive inhibition of AVP at V2 receptors to induce renal electrolyte-free water excretion.
Negative_regulation (inhibition) of AVP associated with hyponatremia
14) Confidence 0.54 Published 2008 Journal Therapeutics and Clinical Risk Management Section Abstract Doc Link PMC2504060 Disease Relevance 0.46 Pain Relevance 0.04
Moreover, plasma AVP was normally suppressed by WL after the replenishment of saline.
Negative_regulation (suppressed) of plasma AVP in plasma
15) Confidence 0.51 Published 1992 Journal Endocrinol. Jpn. Section Abstract Doc Link 1535041 Disease Relevance 0.93 Pain Relevance 0.08
This may explain the difficulty in demonstrating an alpha 2-adrenoceptor agonist-induced inhibition of VP action in other species such as dog and man.
Negative_regulation (inhibition) of VP associated with agonist
16) Confidence 0.50 Published 1992 Journal Pharmacology Section Abstract Doc Link 1348126 Disease Relevance 0 Pain Relevance 0.28
We hypothesized that dobutamine is a useful agent for decreasing the AVP-associated decreases in systemic blood flow and global oxygen transport in ovine endotoxemia.
Negative_regulation (decreasing) of AVP-associated in blood associated with endotoxemia
17) Confidence 0.49 Published 2006 Journal Crit Care Section Body Doc Link PMC1751059 Disease Relevance 0.46 Pain Relevance 0.05
The orally active and selective, non-peptide AVP1a receptor antagonist, SR 49059, has been shown to inhibit the myometrial action of AVP, but the specific influence of this substance on the effects of AVP and other vasoactive agents on human uterine arteries is unknown.
Negative_regulation (inhibit) of AVP in uterine associated with antagonist
18) Confidence 0.43 Published 1998 Journal Acta Obstet Gynecol Scand Section Abstract Doc Link 9492709 Disease Relevance 0.38 Pain Relevance 0.32
In two cohorts of 44 and 18 patients, Sharshar and coworkers [52] evaluated the prevalence of vasopressin deficiency in septic shock.
Negative_regulation (deficiency) of vasopressin associated with cv general 2 under development
19) Confidence 0.43 Published 2005 Journal Crit Care Section Body Doc Link PMC1175907 Disease Relevance 0.74 Pain Relevance 0
Nitric oxide (NO), through cGMP, is a powerful neurohormonal inhibitor of vasopressin [8].
Negative_regulation (inhibitor) of vasopressin
20) Confidence 0.43 Published 2005 Journal Crit Care Section Body Doc Link PMC1175907 Disease Relevance 0.65 Pain Relevance 0.47

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