INT68218

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Context Info
Confidence 0.45
First Reported 1997
Last Reported 2007
Negated 0
Speculated 2
Reported most in Abstract
Documents 3
Total Number 5
Disease Relevance 2.35
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CYP1A1) mitochondrion (CYP1A1) small molecule metabolic process (CYP1A1)
oxidoreductase activity (CYP1A1) endoplasmic reticulum (CYP1A1) enzyme binding (CYP1A1)
Anatomy Link Frequency
lung 3
placenta 3
CYP1A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 1 67.36 Quite High
antagonist 4 65.56 Quite High
Nicotine 8 38.24 Quite Low
beta blocker 2 25.00 Low Low
analgesia 2 25.00 Low Low
fortral 2 25.00 Low Low
Opioid 2 25.00 Low Low
Versed 2 5.00 Very Low Very Low Very Low
Dismenorea 1 5.00 Very Low Very Low Very Low
Dopamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 94 100.00 Very High Very High Very High
Hypoxia 17 95.40 Very High Very High Very High
Cancer 10 95.04 Very High Very High Very High
Stress 30 94.60 High High
Apoptosis 31 90.64 High High
Breast Cancer 11 86.20 High High
Lung Cancer 9 83.84 Quite High
Adverse Drug Reaction 1 59.52 Quite High
Hepatocellular Cancer 1 25.76 Quite Low
Sleep Disorders 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vivo, however, fluparoxan did show some capacity for CYP1A induction.
Regulation (capacity) of Positive_regulation (induction) of CYP1A
1) Confidence 0.45 Published 1997 Journal Xenobiotica Section Abstract Doc Link 9058530 Disease Relevance 0 Pain Relevance 0.10
Regulation of other genes, eg. induction of CYP1A1, IFNGR1 and WARS and downregulation of ER?
Regulation (Regulation) of Positive_regulation (induction) of CYP1A1
2) Confidence 0.42 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.70 Pain Relevance 0
Polycyclic aromatic hydrocarbons in tobacco smoke are believed to be responsible for the induction of cytochrome P450 (CYP) 1A1, CYP1A2 and possibly CYP2E1, CYP1A1 is primarily an extrahepatic enzyme found in lung and placenta.
Spec (possibly) Regulation (responsible) of Spec (possibly) Positive_regulation (induction) of CYP1A1 in placenta associated with nicotine addiction
3) Confidence 0.39 Published 1999 Journal Clin Pharmacokinet Section Abstract Doc Link 10427467 Disease Relevance 0.59 Pain Relevance 0
Our findings of a simultaneous induction of CYP1A1 and CYP1B1 in different lung compartments after exposure to tobacco smoke demonstrate up-regulation of the pulmonary enzyme system and agree well with other reports (McLemore et al. 1990).
Regulation (regulation) of Positive_regulation (induction) of CYP1A1 in lung associated with nicotine addiction
4) Confidence 0.33 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.46 Pain Relevance 0
Polycyclic aromatic hydrocarbons in tobacco smoke are believed to be responsible for the induction of cytochrome P450 (CYP) 1A1, CYP1A2 and possibly CYP2E1, CYP1A1 is primarily an extrahepatic enzyme found in lung and placenta.
Spec (possibly) Regulation (responsible) of in lung Spec (possibly) Positive_regulation (induction) of CYP1A1 in placenta associated with nicotine addiction
5) Confidence 0.13 Published 1999 Journal Clin Pharmacokinet Section Abstract Doc Link 10427467 Disease Relevance 0.59 Pain Relevance 0

General Comments

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