INT6822

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Context Info
Confidence 0.78
First Reported 1983
Last Reported 2010
Negated 5
Speculated 6
Reported most in Abstract
Documents 215
Total Number 230
Disease Relevance 35.99
Pain Relevance 125.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pdyn)
Anatomy Link Frequency
striatum 13
brain 13
spinal cord 10
nucleus accumbens 8
neurons 8
Pdyn (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 1129 100.00 Very High Very High Very High
Enkephalin 423 100.00 Very High Very High Very High
Opioid 357 100.00 Very High Very High Very High
Morphine 128 100.00 Very High Very High Very High
agonist 112 100.00 Very High Very High Very High
Kappa opioid receptor 95 100.00 Very High Very High Very High
substance P 89 100.00 Very High Very High Very High
Neuropeptide 78 100.00 Very High Very High Very High
Delta opioid receptors 19 100.00 Very High Very High Very High
orphanin 13 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Death 42 100.00 Very High Very High Very High
Toxicity 16 100.00 Very High Very High Very High
Repression 2 99.92 Very High Very High Very High
Convulsion 78 99.84 Very High Very High Very High
Vibrio Infection 6 99.84 Very High Very High Very High
Nociception 192 99.82 Very High Very High Very High
Generalized Anxiety Disorder 54 99.60 Very High Very High Very High
Spinal Cord Injury 6 99.50 Very High Very High Very High
Arthritis 4 99.48 Very High Very High Very High
Pox Virus Infection 2 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Big dynorphin, a prodynorphin-derived peptide produces NMDA receptor-mediated effects on memory, anxiolytic-like and locomotor behavior in mice.
Gene_expression (produces) of Big dynorphin associated with dynorphin, nmda receptor, anxiety disorder and enkephalin
1) Confidence 0.78 Published 2006 Journal Neuropsychopharmacology Section Title Doc Link 16292317 Disease Relevance 0.32 Pain Relevance 0.65
Proenkephalin (PENK) and prodynorphin (PDYN) gene expression was measured by in situ hybridization in brain regions implicated in addiction.
Gene_expression (expression) of PDYN in brain
2) Confidence 0.78 Published 2010 Journal Psychopharmacology (Berl.) Section Body Doc Link 19997907 Disease Relevance 0.08 Pain Relevance 0
They suggest that high expression of PDYN may protect against drug abuse by limiting drug-produced reward, which may be due to dynorphin-mediated modulation of dopamine release in the nucleus accumbens.


Gene_expression (expression) of PDYN in nucleus accumbens
3) Confidence 0.78 Published 2010 Journal Psychopharmacology (Berl.) Section Body Doc Link 19997907 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: Our results demonstrate that inter-strain differences in PENK and PDYN genes expression in the nucleus accumbens parallel sensitivity of the selected mouse strains to rewarding effects of morphine.
Gene_expression (expression) of PDYN in nucleus accumbens
4) Confidence 0.78 Published 2010 Journal Psychopharmacology (Berl.) Section Body Doc Link 19997907 Disease Relevance 0.05 Pain Relevance 0
Forebrain PENK and PDYN gene expression levels in three inbred strains of mice and their relationship to genotype-dependent morphine reward sensitivity.
Gene_expression (expression) of PDYN in Forebrain associated with enkephalin, sprains and strains and morphine
5) Confidence 0.78 Published 2010 Journal Psychopharmacology (Berl.) Section Title Doc Link 19997907 Disease Relevance 0.19 Pain Relevance 0.47
Northern blot analysis and reverse transcription-polymerase chain reaction (RT-PCR) combined with Southern blot analysis demonstrated that the expression of ProDYN in both the anterior and posterior pituitary glands was much lower than that in the neural tissues of the striatum and hypothalamus.
Gene_expression (expression) of ProDYN in striatum
6) Confidence 0.77 Published 1997 Journal Gene Section Abstract Doc Link 9074507 Disease Relevance 0 Pain Relevance 0
Opioid peptides derived from the precursor, prodynorphin, are co-localized with vasopressin in the hypothalamus and posterior pituitary, and vasopressin and prodynorphin synthesis are coordinately regulated during salt-loading.
Gene_expression (synthesis) of prodynorphin in posterior pituitary associated with opioid
7) Confidence 0.76 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8255170 Disease Relevance 0 Pain Relevance 0.10
The stably transformed AtT-20 cells that expressed a 1.3-kilobase prodynorphin mRNA also expressed prodynorphin protein and processed it to dynorphin peptides.
Gene_expression (expressed) of prodynorphin protein in AtT-20 associated with dynorphin
8) Confidence 0.76 Published 1989 Journal Mol. Endocrinol. Section Abstract Doc Link 2575215 Disease Relevance 0 Pain Relevance 0.24
Furthermore, in spinal cord nuclear protein extracts, the activity of the transcriptional repressor DREAM (downstream regulatory element antagonist modulator), the main regulator of prodynorphin expression, is lower in IFD than in AL mice.
Gene_expression (expression) of prodynorphin in spinal cord associated with antagonist and spinal cord
9) Confidence 0.75 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14657170 Disease Relevance 0.23 Pain Relevance 0.94
Creating prodynorphin-expressing stem cells alerted for a high-throughput of cardiogenic commitment.
Gene_expression (expressing) of prodynorphin in stem cells associated with enkephalin
10) Confidence 0.75 Published 2007 Journal Regenerative medicine Section Title Doc Link 17465751 Disease Relevance 0 Pain Relevance 0.10
In addition to a transient increase in neurogenesis, MCAO caused a transient up-regulation of preprodynorphin and preproenkephalin mRNA expression in the granule cell layer.
Gene_expression (expression) of preprodynorphin in granule cell associated with middle cerebral artery infarction and neurodegenerative disease
11) Confidence 0.75 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18331339 Disease Relevance 1.23 Pain Relevance 0.49
Third-generation lentiviral vectors were used to overexpress the prodynorphin gene, previously shown to orchestrate a dynorphinergic system acting as a major conductor of embryonic stem cell cardiogenesis.
Gene_expression (overexpress) of prodynorphin in embryonic stem cell
12) Confidence 0.75 Published 2007 Journal Regenerative medicine Section Body Doc Link 17465751 Disease Relevance 0 Pain Relevance 0
XX had higher Pdyn expression than XY or XO mice, indicating that the sex chromosome effect is the result of XX vs.
Gene_expression (expression) of Pdyn
13) Confidence 0.75 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19250439 Disease Relevance 0 Pain Relevance 0.16
In addition, mCREB expression was colocalized with and decreased the expression of prodynorphin in nucleus accumbens medium spiny neurons, and antagonism of dynorphin in the nucleus accumbens was sufficient to produce an antidepressant-like effect similar to that observed after blockade of CREB.
Gene_expression (expression) of prodynorphin in nucleus accumbens associated with nucleus accumbens, antidepressant and dynorphin
14) Confidence 0.75 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12486182 Disease Relevance 0.33 Pain Relevance 0.63
Treatment of MIN6 cells with KCl, forskolin, or isobutyl-methyl-xanthine strongly induced prodynorphin RNA expression, suggesting that induction may be related to secretion-coupled signaling pathways.
Gene_expression (expression) of prodynorphin
15) Confidence 0.75 Published 1998 Journal Endocrinology Section Abstract Doc Link 9751516 Disease Relevance 0.06 Pain Relevance 0.39
Our findings suggest that prodynorphin expression is modulated during ethanol withdrawal convulsions, or alternatively, prodynorphin may mediate the severity of ethanol withdrawal convulsions.
Gene_expression (expression) of prodynorphin associated with convulsion and withdrawal
16) Confidence 0.75 Published 2000 Journal Neurochem. Int. Section Abstract Doc Link 10871698 Disease Relevance 0.77 Pain Relevance 0.42
These data indicate that intrinsic spinal cord neurons may modulate sensory and spinal function in rather subtle ways via the expression of several different opioid peptide products of the dynorphin gene, in addition to the opioid peptides produced by the proenkephalin A gene.
Gene_expression (expression) of dynorphin gene in spinal associated with dynorphin, opioid and spinal cord
17) Confidence 0.72 Published 1986 Journal Neuroscience Section Abstract Doc Link 2876400 Disease Relevance 0.16 Pain Relevance 1.05
Prodynorphin messenger RNA expression and dynorphin A (1-17)-like immunoreactivity on the ipsilateral side of the spinal cord were markedly increased in complete Freund's adjuvant-injected mice.
Gene_expression (expression) of Prodynorphin in spinal cord
18) Confidence 0.68 Published 2010 Journal Anesthesiology Section Body Doc Link 20068450 Disease Relevance 0 Pain Relevance 0
METHODS: The changes in prodynorphin messenger RNA expression and dynorphin A (1-17)-like immunoreactivity in the mouse spinal cord were determined after the intraplantar injection of complete Freund's adjuvant in mice.
Gene_expression (expression) of prodynorphin in spinal cord
19) Confidence 0.68 Published 2010 Journal Anesthesiology Section Body Doc Link 20068450 Disease Relevance 0 Pain Relevance 0
OBJECTIVE: We determined whether administration of a single dose of nicotine alters the biosynthesis of Dyn in the striatum of mice.
Gene_expression (biosynthesis) of Dyn in striatum
20) Confidence 0.68 Published 2009 Journal Psychopharmacology (Berl.) Section Body Doc Link 18807250 Disease Relevance 0 Pain Relevance 0

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