INT68220

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 0.80
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CYP1A1) mitochondrion (CYP1A1) small molecule metabolic process (CYP1A1)
oxidoreductase activity (CYP1A1) endoplasmic reticulum (CYP1A1) enzyme binding (CYP1A1)
Anatomy Link Frequency
1A2 1
lung 1
CYP1A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 9 91.92 High High
carbamazepine 11 77.28 Quite High
fluoxetine 7 75.60 Quite High
diclofenac 6 74.24 Quite High
Paracetamol 5 67.60 Quite High
Inflammation 1 58.84 Quite High
Analgesic 2 57.96 Quite High
cINOD 3 52.44 Quite High
tolerance 1 45.44 Quite Low
Nicotine 3 25.36 Quite Low
Disease Link Frequency Relevance Heat
Lung Cancer 1 99.32 Very High Very High Very High
Stress 4 99.08 Very High Very High Very High
Nicotine Addiction 8 92.64 High High
Toxicity 3 92.16 High High
INFLAMMATION 3 58.84 Quite High
Occupational Lung Diseases 1 56.56 Quite High
Arrhythmia Under Development 4 5.24 Low Low
Obesity 2 5.00 Very Low Very Low Very Low
Organ Transplantation 2 5.00 Very Low Very Low Very Low
Peptic Ulcer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Structure-activity analysis indicated some potential for CYP1A interaction, although its greater log P and molecular depth, compared with many CYP1A inducers, suggested fluparoxan would be a weak ligand for the aryl hydrocarbon (Ah) receptor and only a weak inducer. 3.
CYP1A Binding (interaction) of
1) Confidence 0.48 Published 1997 Journal Xenobiotica Section Abstract Doc Link 9058530 Disease Relevance 0 Pain Relevance 0.05
In vitro, fluparoxan showed little affinity for the CYP1A enzymes.
CYP1A Neg (little) Binding (affinity) of
2) Confidence 0.48 Published 1997 Journal Xenobiotica Section Abstract Doc Link 9058530 Disease Relevance 0 Pain Relevance 0.04
Minor fractions were catalyzed by recombinant P450s CYP1A1, CYP2B6, CYP2C19, CYP2D6, and CYP2E1.
CYP1A1 Binding (recombinant) of
3) Confidence 0.36 Published 2009 Journal Drug Metab. Dispos. Section Abstract Doc Link 19204080 Disease Relevance 0.11 Pain Relevance 0.14
We have previously shown that residue 382 affected CYP1A1 and CYP1A2 specificities with alkoxyresorufins.
CYP1A1 Binding (specificities) of
4) Confidence 0.35 Published 2010 Journal Drug Metab. Dispos. Section Abstract Doc Link 20335269 Disease Relevance 0 Pain Relevance 0
The compound was not metabolized by human CYP1A1 or 1A2 heterologously expressed in yeast and its rate of metabolism in rat and human microsomes was unaffected by the addition of the 1A inhibitor alpha-naphthoflavone.
CYP1A1 Binding (metabolized) of in 1A2
5) Confidence 0.32 Published 1997 Journal Xenobiotica Section Abstract Doc Link 9058530 Disease Relevance 0 Pain Relevance 0.04
There is a strong association between the activity of CYP1A1 and the risk of lung cancer [8].
CYP1A1 Binding (association) of in lung associated with lung cancer
6) Confidence 0.09 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2584094 Disease Relevance 0.31 Pain Relevance 0.07
Cell viability, interaction with cytochrome P450 1A (CYP1A) enzyme and oxidative stress were assessed by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrasodium bromide tetrazolium (MTT), 7-ethoxyresorufin-o-deethylase (EROD) and dichlorofluorescein (DCFH-DA) assays, respectively.
cytochrome P450 1A Binding (interaction) of associated with stress
7) Confidence 0.07 Published 2004 Journal Toxicology Section Abstract Doc Link 15036755 Disease Relevance 0.19 Pain Relevance 0.32
Cell viability, interaction with cytochrome P450 1A (CYP1A) enzyme and oxidative stress were assessed by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrasodium bromide tetrazolium (MTT), 7-ethoxyresorufin-o-deethylase (EROD) and dichlorofluorescein (DCFH-DA) assays, respectively.
CYP1A Binding (interaction) of associated with stress
8) Confidence 0.07 Published 2004 Journal Toxicology Section Abstract Doc Link 15036755 Disease Relevance 0.19 Pain Relevance 0.33

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox