INT6823

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Context Info
Confidence 0.58
First Reported 1982
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 68
Total Number 69
Disease Relevance 13.95
Pain Relevance 46.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pdyn)
Anatomy Link Frequency
brains 6
spinal cord 5
hippocampus 4
striatum 3
frontal cortex 2
Pdyn (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 398 100.00 Very High Very High Very High
Enkephalin 77 100.00 Very High Very High Very High
Kappa opioid receptor 70 100.00 Very High Very High Very High
narcan 40 100.00 Very High Very High Very High
Glutamate 12 100.00 Very High Very High Very High
Antinociceptive 31 99.84 Very High Very High Very High
Dopamine 133 99.64 Very High Very High Very High
Action potential 5 99.52 Very High Very High Very High
nalbuphine 14 99.48 Very High Very High Very High
Spinal cord 36 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sprains And Strains 3 99.98 Very High Very High Very High
Aids-related Complex 11 99.68 Very High Very High Very High
Targeted Disruption 39 99.58 Very High Very High Very High
Urological Neuroanatomy 7 99.40 Very High Very High Very High
Hemorrhage 2 99.12 Very High Very High Very High
Pain 7 99.04 Very High Very High Very High
Convulsion 15 98.82 Very High Very High Very High
Eating Disorder 12 98.82 Very High Very High Very High
Spinal Cord Injury 4 98.76 Very High Very High Very High
Injury 15 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Analysis of film autoradiograms revealed no changes in prodynorphin mRNA level, but statistically significant decrease in the level of proenkephalin mRNA in striatum in young CB mice in comparison with young controls; no difference was observed between adult CB and control animals.
Negative_regulation (decrease) of proenkephalin mRNA in striatum
1) Confidence 0.58 Published 2007 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 17493673 Disease Relevance 0.25 Pain Relevance 0.31
Dynorphin (Dyn) and methionine-enkephalin (ME) levels were also decreased.
Negative_regulation (decreased) of Dynorphin associated with dynorphin and enkephalin
2) Confidence 0.54 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 2893279 Disease Relevance 0.26 Pain Relevance 0.52
Mice injected with gold thioglucose (GTG) also showed a decrease in the hypothalamic content of beta-E and Dyn and exhibited 30% less analgesia compared to control mice after cold swim stress.
Negative_regulation (decrease) of Dyn associated with stress, dynorphin and analgesia
3) Confidence 0.54 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 2893279 Disease Relevance 0.33 Pain Relevance 0.53
Dynorphin (Dyn) and methionine-enkephalin (ME) levels were also decreased.
Negative_regulation (decreased) of Dyn associated with dynorphin and enkephalin
4) Confidence 0.54 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 2893279 Disease Relevance 0.26 Pain Relevance 0.52
We demonstrated that the antinociceptive action of morphine was enhanced by procedures that are known to attenuate Dyn action.
Negative_regulation (attenuate) of Dyn associated with antinociceptive and morphine
5) Confidence 0.43 Published 1993 Journal Anesth. Analg. Section Abstract Doc Link 7902680 Disease Relevance 0 Pain Relevance 1.09
Dyn was decreased in both ventral and dorsal striatum, and PD mRNA was differentially increased in the two striatal compartments as demonstrated by in situ hybridization.
Negative_regulation (decreased) of Dyn in striatum associated with dynorphin
6) Confidence 0.43 Published 2008 Journal Synapse Section Abstract Doc Link 18361441 Disease Relevance 0.21 Pain Relevance 0.84
Distribution of dynorphin B and methionine-enkephalin in the mouse hippocampus: influence of genotype.
Negative_regulation (Distribution) of dynorphin B in hippocampus associated with dynorphin, hippocampus and enkephalin
7) Confidence 0.43 Published 1989 Journal Neurosci. Lett. Section Title Doc Link 2566141 Disease Relevance 0.08 Pain Relevance 0.52
Mild postnatal manipulation reduces proenkephalin mRNA in the striatum in developing mice and increases morphine conditioned place preference in adulthood.
Negative_regulation (reduces) of proenkephalin mRNA in striatum associated with enkephalin and morphine
8) Confidence 0.43 Published 2007 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 17493673 Disease Relevance 0.21 Pain Relevance 0.36
Activation of central benzodiazepine receptors preceded the IL1beta step because flumazenil inhibited Dyn but not IL1beta antianalgesia.
Negative_regulation (inhibited) of Dyn
9) Confidence 0.42 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11602679 Disease Relevance 0 Pain Relevance 0.75
Thus, the paralytic effects of Dyn A may result from non-opioid actions of Dyn A to reduce spinal cord perfusion.
Negative_regulation (effects) of Dyn in spinal cord associated with opioid and spinal cord
10) Confidence 0.42 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 2893280 Disease Relevance 0.17 Pain Relevance 0.60
The involvement of dynorphin on Delta-9-tetrahydrocannabinol (THC) and morphine responses has been investigated by using mice with a targeted inactivation of the prodynorphin (Pdyn) gene.
Negative_regulation (inactivation) of prodynorphin associated with dynorphin, delta-9-tetrahydrocannabinol and morphine
11) Confidence 0.42 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11717384 Disease Relevance 0 Pain Relevance 0.78
The involvement of dynorphin on Delta-9-tetrahydrocannabinol (THC) and morphine responses has been investigated by using mice with a targeted inactivation of the prodynorphin (Pdyn) gene.
Negative_regulation (inactivation) of Pdyn associated with dynorphin, delta-9-tetrahydrocannabinol and morphine
12) Confidence 0.42 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11717384 Disease Relevance 0 Pain Relevance 0.79
Here, mice lacking the prodynorphin gene were studied for sensitivity to non-noxious and noxious stimuli, before and after induction of experimental neuropathic pain.
Negative_regulation (lacking) of prodynorphin associated with neuropathic pain
13) Confidence 0.42 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11222667 Disease Relevance 0.57 Pain Relevance 0.71
Pdyn gene deficiency potentiates nalbuphine-induced behavioral sensitization of locomotor activity and accumbal c-Fos expression.
Negative_regulation (deficiency) of Pdyn associated with eae and nalbuphine
14) Confidence 0.42 Published 2009 Journal Drug Alcohol Depend Section Abstract Doc Link 19559544 Disease Relevance 0.37 Pain Relevance 0.89
DREAM (downstream regulatory element antagonistic modulator) is a novel transcriptional repressor for the prodynorphin gene, and genetic deletion of DREAM in mice results in a phenotype of ongoing analgesia by virtue of its effect on opioid gene expression.
Negative_regulation (repressor) of prodynorphin associated with opioid and analgesia
15) Confidence 0.41 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15182311 Disease Relevance 0 Pain Relevance 0.88
Here, these possibilities were explored using mice with a deletion of the gene encoding prodynorphin.
Negative_regulation (deletion) of prodynorphin
16) Confidence 0.41 Published 2002 Journal Pain Section Abstract Doc Link 12467995 Disease Relevance 0.48 Pain Relevance 0.89
The reduction in open-arm time was blocked by pretreatment with the KOR antagonist norbinaltorphimine (norBNI), and was not evident in mice lacking the endogenous KOR ligand dynorphin.
Negative_regulation (lacking) of dynorphin in arm associated with dynorphin, antagonist and kappa opioid receptor
17) Confidence 0.41 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2795205 Disease Relevance 0.51 Pain Relevance 0.76
This antianalgesic action was demonstrated to be mediated by spinal Dyn A in the following ways: 1) the antagonistic effect of i.c.v. naloxone and N-BNI was eliminated by administration of small doses of i.t. naloxone and N-BNI, a unique situation where administration of the opioid antagonists at a second (i.t.) site reversed the antagonistic effect of opioid antagonists administered at the other (i.c.v.) site; 2) i.t. pretreatment with dynorphin antiserum prevented the antianalgesic effect; 3) morphine pretreatment (s.c., 10 mg/kg), which produces desensitization to the effect of spinal Dyn A, eliminated the antianalgesic effect; and 4) pretreatment with i.c.v. naloxone (3 hours) and N-BNI (24 hours) which presumably releases Dyn A produced desensitization to the antagonistic effect of i.c.v. naloxone and N-BNI as well as to the antianalgesic action of i.t.
Negative_regulation (effect) of Dyn in spinal associated with dynorphin, antagonist, narcan, opioid and morphine
18) Confidence 0.38 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1348537 Disease Relevance 0 Pain Relevance 1.43
Responses to DYN differed from responses to Leu-enkephalin in that only DYN decreases of somatic CAP duration were associated with decreased action potential after hyperpolarization and persisted after intracellular injection of the potassium channel blocker cesium.
Negative_regulation (decreases) of DYN associated with action potential, potassium channel and enkephalin
19) Confidence 0.36 Published 1984 Journal Neuropeptides Section Abstract Doc Link 6152324 Disease Relevance 0.41 Pain Relevance 0.90
Prodynorphin gene deficiency potentiates nalbuphine-induced behavioral sensitization and withdrawal syndrome in mice.
Negative_regulation (deficiency) of Prodynorphin gene associated with nalbuphine, enkephalin and withdrawal
20) Confidence 0.36 Published 2009 Journal Drug Alcohol Depend Section Title Doc Link 19559544 Disease Relevance 0.37 Pain Relevance 1.23

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