INT68235

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 1997
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 39
Total Number 40
Disease Relevance 30.96
Pain Relevance 2.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
bars 2
blood 1
cartilage 1
spleens 1
PSP 1
IgG2a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 417 100.00 Very High Very High Very High
narcan 10 99.88 Very High Very High Very High
Inflammation 158 95.56 Very High Very High Very High
Enkephalin 7 94.68 High High
chemokine 64 94.56 High High
antagonist 2 75.00 Quite High
Neuritis 2 75.00 Quite High
Opioid 2 75.00 Quite High
Demyelination 2 68.92 Quite High
Multiple sclerosis 5 55.52 Quite High
Disease Link Frequency Relevance Heat
Immunization 746 99.98 Very High Very High Very High
Chlamydia Infection 382 99.98 Very High Very High Very High
Sprains And Strains 322 99.98 Very High Very High Very High
Cold Sores 7 99.48 Very High Very High Very High
Lewis Lung Carcinoma 544 99.44 Very High Very High Very High
Infection 569 99.32 Very High Very High Very High
Toxoplasmosis 12 99.30 Very High Very High Very High
Aspergillus Infection 44 99.28 Very High Very High Very High
Cancer 290 99.08 Very High Very High Very High
Hypersensitivity 142 98.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NLX also increased the IgG2a/IgG1 ratio, though it did not affect the production of HSV-1 antiserum.
Positive_regulation (increased) of IgG2a associated with cold sores and narcan
1) Confidence 0.49 Published 2009 Journal Int. Immunol. Section Abstract Doc Link 19174474 Disease Relevance 1.01 Pain Relevance 0.51
One of the interesting observations from the present study is the fact that the functional integrity of hemagglutinin is a critical determining factor for inducing IgG2a isotype antibody after microneedle or intramuscular delivery of vaccine as well as for inducing antibody responses to influenza.
Positive_regulation (inducing) of IgG2a associated with influenza virus infection
2) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745577 Disease Relevance 0.48 Pain Relevance 0
The trehalose-stabilized vaccines (MN+T, IM+T) induced IgG2a as the dominant isotype (Fig. 3B, 3D, 3E, and Table 2).
Positive_regulation (induced) of IgG2a associated with immunization
3) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745577 Disease Relevance 0.88 Pain Relevance 0
In contrast, the OSP-induced Abs were predominantly directed against OSP22-46; these Abs were mostly of IgG1 isotype, but high levels of IgG2a and IgG2b and significant levels of IgE were also observed.
Positive_regulation (levels) of IgG2a
4) Confidence 0.40 Published 2006 Journal J. Immunol. Section Abstract Doc Link 17082656 Disease Relevance 0.70 Pain Relevance 0.24
Furthermore, we could not observe elevated IgG2a levels in in vivo experiments, which were shown in in vitro experiments.
Neg (not) Positive_regulation (elevated) of IgG2a
5) Confidence 0.38 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0.19 Pain Relevance 0
By day 28, there were small increases in the IgG1/IgG2a ratios in all groups, but the trends were unchanged (Figure 3C, D).
Positive_regulation (increases) of IgG2a
6) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651574 Disease Relevance 0.54 Pain Relevance 0
In contrast, PENK induced no change in the production of Ig isotypes at any time point of addition, with the exception of IgG1 and IgG2a that were enhanced when PENK was added 6 h after cell activation.
Positive_regulation (enhanced) of IgG2a
7) Confidence 0.29 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9058757 Disease Relevance 0 Pain Relevance 0.42
Our study demonstrates that CTH1/CAF01 vaccination induced high levels of CTH1 specific IgG1 and IgG2a both in blood and vaginal secretions.
Positive_regulation (levels) of IgG2a in blood
8) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2874006 Disease Relevance 0.41 Pain Relevance 0
In our present study, CpG induced the highest IgG2a titers among all M-TCI groups and our results strongly support a skewing of the Th1/Th2 balance towards the Th1 direction, similar to the immune modulatory effect of CpG in mucosal and injection vaccination.
Positive_regulation (induced) of IgG2a associated with immunization
9) Confidence 0.27 Published 2009 Journal Pharm Res Section Body Doc Link PMC2689355 Disease Relevance 0.60 Pain Relevance 0.10
IgG1/IgG2a ratios were calculated only using IgG2a responders.
Positive_regulation (calculated) of IgG2a
10) Confidence 0.27 Published 2009 Journal Pharm Res Section Body Doc Link PMC2689355 Disease Relevance 0.41 Pain Relevance 0
Furthermore, alum in M-TCI did not induce detectable IgG2a titers and provided no protection in the Vero cell test after the second boost (data not shown).
Neg (not) Positive_regulation (induce) of IgG2a associated with immunization
11) Confidence 0.27 Published 2009 Journal Pharm Res Section Body Doc Link PMC2689355 Disease Relevance 0.19 Pain Relevance 0
Applying plain DT by M-TCI induced the same IgG1/IgG2a ratio as by s.c. injection.
Positive_regulation (induced) of IgG2a associated with immunization
12) Confidence 0.27 Published 2009 Journal Pharm Res Section Body Doc Link PMC2689355 Disease Relevance 0.31 Pain Relevance 0
PSP enhanced the OVA-specific IgE antibody responses in all strains of mice examined, whereas the IgG2a response was increased to varying degrees and only in some strains.
Positive_regulation (increased) of IgG2a in PSP associated with sprains and strains
13) Confidence 0.26 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1182367 Disease Relevance 0.83 Pain Relevance 0.15
In contrast, the IgG2a levels were significantly increased only in NIH and C3H/HeN mice.
Positive_regulation (increased) of IgG2a
14) Confidence 0.26 Published 2005 Journal BMC Immunol Section Abstract Doc Link PMC1182367 Disease Relevance 0.51 Pain Relevance 0.16
Vaccination with a single low dose of CpG-dinucleotide inhibited OVA-specific IgE production with subsequent upregulation of IgG2a in both groups.
Positive_regulation (upregulation) of IgG2a
15) Confidence 0.26 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0.31 Pain Relevance 0.11
The titer of IgG2a (lower panel), in contrast to that of IgG1, elevated as the dose of vitamin C increased up to 0.25 mM with statistical significance compared to the control group (32.3±1.7 vs 49.3 ±1.2, P<0.05).


Positive_regulation (elevated) of IgG2a
16) Confidence 0.25 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0 Pain Relevance 0
Similarly to our previous findings [12,17], Af sensitization resulted in markedly increased serum IgE, IgG1 and IgG2a levels.
Positive_regulation (increased) of IgG2a associated with aspergillus infection
17) Confidence 0.24 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 1.27 Pain Relevance 0.04
In contrast, the Qro strain induced only IgM and IgG2a in the early acute phase, with a notable difference in recognized antigens.
Positive_regulation (induced) of IgG2a associated with sprains and strains
18) Confidence 0.22 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2852613 Disease Relevance 0.91 Pain Relevance 0.14
IgG2a titers were increased in T. gondii-infected cancer-bearing mice
Positive_regulation (increased) of IgG2a associated with cancer
19) Confidence 0.21 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2694397 Disease Relevance 3.14 Pain Relevance 0
Toxoplasma infection of LLC-bearing mice significantly increased the survival rates, serum IgG2a titers, IFN-?
Positive_regulation (increased) of IgG2a associated with lewis lung carcinoma and toxoplasmosis
20) Confidence 0.21 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2694397 Disease Relevance 1.44 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox