INT6824

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Context Info
Confidence 0.62
First Reported 1985
Last Reported 2009
Negated 19
Speculated 9
Reported most in Abstract
Documents 114
Total Number 123
Disease Relevance 9.48
Pain Relevance 66.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pdyn) plasma membrane (Pdyn)
Anatomy Link Frequency
brain 31
hippocampus 23
striatum 19
nucleus accumbens 16
hypothalamus 13
Pdyn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 216 100.00 Very High Very High Very High
Enkephalin 189 100.00 Very High Very High Very High
Dynorphin 155 100.00 Very High Very High Very High
Hippocampus 105 100.00 Very High Very High Very High
Opioid 94 100.00 Very High Very High Very High
Serotonin 78 100.00 Very High Very High Very High
Dopamine 72 100.00 Very High Very High Very High
Morphine 60 100.00 Very High Very High Very High
fluoxetine 39 100.00 Very High Very High Very High
MU agonist 30 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Parkinson's Disease 1 100.00 Very High Very High Very High
Convulsion 29 99.62 Very High Very High Very High
INFLAMMATION 9 99.08 Very High Very High Very High
Cancer 2 99.04 Very High Very High Very High
Drug Dependence 13 98.92 Very High Very High Very High
Pain 5 98.16 Very High Very High Very High
Injury 11 98.08 Very High Very High Very High
Urological Neuroanatomy 11 96.92 Very High Very High Very High
Dyskinesias 11 95.80 Very High Very High Very High
Nociception 3 95.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that PDYN gene expression regulation by cocaine in the caudate putamen might be due to a combination of effects on two or three monoamine transporters, or to a mechanism unrelated to transporters inhibition.
Regulation (regulation) of Gene_expression (expression) of PDYN gene in caudate putamen associated with monoamine and cocaine
1) Confidence 0.62 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15306127 Disease Relevance 0 Pain Relevance 0.58
Repeated imipramine administration (10 mg/kg i.p. twice daily for 10 days) had no effect on proenkephalin mRNA level, whereas the prodynorphin gene expression was regulated differently.
Regulation (regulated) of Gene_expression (expression) of prodynorphin
2) Confidence 0.62 Published 1997 Journal Pol J Pharmacol Section Abstract Doc Link 9566035 Disease Relevance 0 Pain Relevance 0.39
Age-related changes in brain proDynorphin gene expression in the rat.
Regulation (changes) of Gene_expression (expression) of proDynorphin in brain associated with enkephalin
3) Confidence 0.62 Published 2004 Journal Neurobiol. Aging Section Title Doc Link 15465632 Disease Relevance 0 Pain Relevance 0.29
Alterations in prodynorphin gene expression and dynorphin levels in different brain regions after chronic administration of 14-methoxymetopon and oxycodone-6-oxime.
Regulation (Alterations) of Gene_expression (expression) of prodynorphin in brain associated with oxycodone, dynorphin and enkephalin
4) Confidence 0.62 Published 2006 Journal Brain Res. Bull. Section Title Doc Link 16861108 Disease Relevance 0.09 Pain Relevance 1.63
In nucleus accumbens and the temporal-parietal cortex the changes in the prodynorphin gene expression and the dynorphin levels did not correlate.
Regulation (changes) of Gene_expression (expression) of prodynorphin in parietal cortex associated with nucleus accumbens and dynorphin
5) Confidence 0.62 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 16861108 Disease Relevance 0.05 Pain Relevance 1.66
In the hippocampus both oxycodone-6-oxime and 14-methoxymetopon enhanced, whereas morphine did not alter the prodynorphin gene expression.
Neg (not) Regulation (alter) of Gene_expression (expression) of prodynorphin in hippocampus associated with oxycodone, hippocampus and morphine
6) Confidence 0.62 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 16861108 Disease Relevance 0.07 Pain Relevance 1.74
Thus, chronic inhibition of serotonin uptake can regulate prodynorphin gene expression in the hypothalamus, caudate putamen, and nucleus accumbens.
Regulation (regulate) of Gene_expression (expression) of prodynorphin in nucleus accumbens associated with nucleus accumbens and serotonin
7) Confidence 0.62 Published 2004 Journal J. Mol. Neurosci. Section Abstract Doc Link 14997015 Disease Relevance 0 Pain Relevance 0.85
Role of serotonin on cocaine-mediated effects on prodynorphin gene expression in the rat brain.
Regulation (Role) of Gene_expression (expression) of prodynorphin in brain associated with enkephalin, serotonin and cocaine
8) Confidence 0.62 Published 2004 Journal J. Mol. Neurosci. Section Title Doc Link 14997015 Disease Relevance 0 Pain Relevance 0.94
Because we previously reported that continuous infusion of cocaine for 7 d (which inhibits dopamine, serotonin, and norepinephrine uptake), or GBR 12909 (a selective dopamine uptake inhibitor), produced significant decreases in the hypothalamus and cocaine also produced a significant increase in prodynorphin gene expression in caudate putamen, regulation of prodynorphin gene expression by fluoxetine is suggested to be different from that by cocaine.
Regulation (regulation) of Gene_expression (expression) of prodynorphin in caudate putamen associated with dopamine, serotonin, fluoxetine and cocaine
9) Confidence 0.62 Published 2004 Journal J. Mol. Neurosci. Section Abstract Doc Link 14997015 Disease Relevance 0 Pain Relevance 1.06
These findings suggest that regulation of prodynorphin gene expression by cocaine in the caudate putamen may be mediated by the inhibition of norepinephrine or serotonin uptake, by a combination of effects on two or three monoamine transporters, or by a mechanism unrelated to transporter inhibition.
Regulation (regulation) of Gene_expression (expression) of prodynorphin gene in caudate putamen associated with serotonin, monoamine and cocaine
10) Confidence 0.62 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11226394 Disease Relevance 0 Pain Relevance 0.52
We investigated the effect of long-term administration of opioid antagonists on the regulation of prodynorphin gene expression in rat brain.
Regulation (regulation) of Gene_expression (expression) of prodynorphin gene in brain associated with antagonist and opioid
11) Confidence 0.62 Published 1995 Journal Brain Res. Section Abstract Doc Link 7749752 Disease Relevance 0 Pain Relevance 0.78
Identification of multiple DNA elements regulating basal and protein kinase A-induced transcriptional expression of the rat prodynorphin gene.
Regulation (regulating) of Gene_expression (expression) of prodynorphin gene associated with enkephalin
12) Confidence 0.62 Published 1994 Journal Mol. Endocrinol. Section Title Doc Link 8015551 Disease Relevance 0 Pain Relevance 0.24
Much is known regarding the physiological and receptor-mediated events that regulate prodynorphin gene expression in vivo.
Regulation (regulate) of Gene_expression (expression) of prodynorphin gene
13) Confidence 0.62 Published 1994 Journal Mol. Endocrinol. Section Abstract Doc Link 8015551 Disease Relevance 0 Pain Relevance 0.14
Prenatal cocaine did not affect the expression of proenkephalin mRNA, but males showed higher expression than females.
Neg (not) Regulation (affect) of Gene_expression (expression) of proenkephalin mRNA associated with cocaine
14) Confidence 0.62 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17574751 Disease Relevance 0 Pain Relevance 0.35
The effect of a chronic morphine treatment on prodynorphin gene expression has been studied.
Regulation (effect) of Gene_expression (expression) of prodynorphin gene associated with morphine
15) Confidence 0.62 Published 1990 Journal Ann. Ist. Super. Sanita Section Abstract Doc Link 2393216 Disease Relevance 0 Pain Relevance 0.55
These results indicate that continuously infused cocaine is able to modulate expression of the prodynorphin gene in opposite directions or has no effect on prodynorphin expression, depending on the brain region analysed.
Regulation (modulate) of Gene_expression (expression) of prodynorphin gene in brain associated with cocaine
16) Confidence 0.62 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8840025 Disease Relevance 0 Pain Relevance 0.56
Chronic intracerebroventricular cocaine differentially affects prodynorphin gene expression in rat hypothalamus and caudate-putamen.
Regulation (affects) of Gene_expression (expression) of prodynorphin gene in hypothalamus associated with enkephalin, intracerebroventricular and cocaine
17) Confidence 0.62 Published 1996 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 8840025 Disease Relevance 0 Pain Relevance 0.62
We investigated the effects of sustained administration of cocaine on the regulation of prodynorphin gene expression in rat brain.
Regulation (regulation) of Gene_expression (expression) of prodynorphin gene in brain associated with cocaine
18) Confidence 0.62 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8840025 Disease Relevance 0 Pain Relevance 0.35
These data demonstrate that the regulation of preprodynorphin gene expression is dissociable from that of c-fos and zif/268 in dorsal striatum following short-term cocaine self-administration.
Regulation (regulation) of Gene_expression (expression) of preprodynorphin gene in striatum associated with cocaine
19) Confidence 0.62 Published 1995 Journal Brain Res. Bull. Section Abstract Doc Link 7633900 Disease Relevance 0 Pain Relevance 0.18
Regulated expression of the prodynorphin gene in the R2C Leydig tumor cell line.
Regulation (Regulated) of Gene_expression (expression) of prodynorphin in R2C associated with cancer and enkephalin
20) Confidence 0.62 Published 1989 Journal Endocrinology Section Title Doc Link 2462494 Disease Relevance 0.19 Pain Relevance 0.10

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