INT68243

Context Info Confidence 0.44 First Reported 1997 Last Reported 2010 Negated 4 Speculated 0 Reported most in Body Documents 10 Total Number 10 Disease Relevance 4.93 Pain Relevance 2.04

Anatomy Link Frequency B cells 2 plaques 2 CII 2 respiratory 2 IgG (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 94 100.00 Arthritis 81 100.00 cytokine 23 100.00 Enkephalin 7 99.68 narcan 1 98.44 methotrexate 15 90.60 dexamethasone 5 90.40 rheumatoid arthritis 101 86.64 cINOD 1 69.24 Etanercept 22 60.28

Disease Link Frequency Relevance Heat Arthritis 112 100.00 INFLAMMATION 99 100.00 Penile Induration 11 100.00 Malaria 50 99.80 Lower Respiratory Tract Infection 6 99.28 Influenza Virus Infection 33 99.06 Autoimmune Disease 8 98.68 Infection 52 94.32 Hypergammaglobulinemia 1 91.96 Idiopathic Thrombocytopenic Purpura 1 89.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Indeed, Hamilton et al74 demonstrated such an immune response to injection of CHC for the treatment of PD plaques: pretreatment, anticollagenase IgG was detected in 34% of the healthy controls vs 58% of untreated PD patients.

Regulation (response) of Gene_expression (detected) of IgG in plaques associated with penile induration

1) Confidence 0.44 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2988615 Disease Relevance 0.27 Pain Relevance 0

The synthesis of IgG is driven by immunogenic stimulation and is not affected by the rate of catabolism [46].

Neg (not) Regulation (affected) of Gene_expression (synthesis) of IgG

2) Confidence 0.26 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 0.76 Pain Relevance 0.08

D-PA failed to influence anti-OVA IgG, IgG2a and IgG1 production as well as IFN-gamma and IL-10 secretion.

Neg (failed) Regulation (influence) of Gene_expression (production) of IgG

3) Confidence 0.19 Published 2005 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 15698518 Disease Relevance 0.58 Pain Relevance 0.58

Hormonal status does not affect arthritis-induced increased levels of pro-inflammatory cytokines, IgG and CII antibodies

Neg (not) Regulation (affect) of Gene_expression (levels) of IgG in CII associated with inflammation, cytokine and arthritis

4) Confidence 0.16 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175035 Disease Relevance 1.34 Pain Relevance 0.45

On day 21, the impairment of humoral responses was more pronounced with respect to influenza as compared with the pneumococcal vaccine and affected both IgG and light-chain production.

Regulation (affected) of Gene_expression (production) of IgG associated with influenza virus infection

5) Confidence 0.13 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2911904 Disease Relevance 0.84 Pain Relevance 0.21

Ultralow concentrations of proenkephalin and [met5]-enkephalin differentially affect IgM and IgG production by B cells.

Regulation (affect) of Gene_expression (production) of IgG in B cells associated with enkephalin

6) Confidence 0.11 Published 1997 Journal J. Neuroimmunol. Section Title Doc Link 9058757 Disease Relevance 0 Pain Relevance 0.68

Effects of nano particles on adjuvant activity for total IgE and antigen-specific production of IgG and IgE

Regulation (Effects) of Gene_expression (production) of IgG

7) Confidence 0.09 Published 2005 Journal Respir Res Section Body Doc Link PMC1242256 Disease Relevance 0 Pain Relevance 0

Relationship between R0-GLURP IgG levels and Plasmodium falciparum density in Mgome (high transmission village)

Regulation (Relationship) of Gene_expression (levels) of IgG associated with malaria

8) Confidence 0.07 Published 2005 Journal Malar J Section Body Doc Link PMC1262760 Disease Relevance 0.10 Pain Relevance 0

Lagged analysis of the longitudinal data showed that salivary IgA and IgG levels were primarily affected by the number of respiratory infections in the preceding 2 months.

Regulation (affected) of Gene_expression (levels) of IgG in respiratory associated with lower respiratory tract infection

9) Confidence 0.05 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC3017893 Disease Relevance 0.67 Pain Relevance 0

Patient 2 showed no relevant variations regarding IgG and IgA levels.

Neg (no) Regulation (regarding) of Gene_expression (levels) of IgG

10) Confidence 0.03 Published 2009 Journal The Open Rheumatology Journal Section Body Doc Link PMC2684711 Disease Relevance 0.38 Pain Relevance 0.03

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