INT68243

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Context Info
Confidence 0.44
First Reported 1997
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 4.93
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
B cells 2
plaques 2
CII 2
respiratory 2
IgG (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 94 100.00 Very High Very High Very High
Arthritis 81 100.00 Very High Very High Very High
cytokine 23 100.00 Very High Very High Very High
Enkephalin 7 99.68 Very High Very High Very High
narcan 1 98.44 Very High Very High Very High
methotrexate 15 90.60 High High
dexamethasone 5 90.40 High High
rheumatoid arthritis 101 86.64 High High
cINOD 1 69.24 Quite High
Etanercept 22 60.28 Quite High
Disease Link Frequency Relevance Heat
Arthritis 112 100.00 Very High Very High Very High
INFLAMMATION 99 100.00 Very High Very High Very High
Penile Induration 11 100.00 Very High Very High Very High
Malaria 50 99.80 Very High Very High Very High
Lower Respiratory Tract Infection 6 99.28 Very High Very High Very High
Influenza Virus Infection 33 99.06 Very High Very High Very High
Autoimmune Disease 8 98.68 Very High Very High Very High
Infection 52 94.32 High High
Hypergammaglobulinemia 1 91.96 High High
Idiopathic Thrombocytopenic Purpura 1 89.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, Hamilton et al74 demonstrated such an immune response to injection of CHC for the treatment of PD plaques: pretreatment, anticollagenase IgG was detected in 34% of the healthy controls vs 58% of untreated PD patients.
Regulation (response) of Gene_expression (detected) of IgG in plaques associated with penile induration
1) Confidence 0.44 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2988615 Disease Relevance 0.27 Pain Relevance 0
The synthesis of IgG is driven by immunogenic stimulation and is not affected by the rate of catabolism [46].
Neg (not) Regulation (affected) of Gene_expression (synthesis) of IgG
2) Confidence 0.26 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 0.76 Pain Relevance 0.08
D-PA failed to influence anti-OVA IgG, IgG2a and IgG1 production as well as IFN-gamma and IL-10 secretion.
Neg (failed) Regulation (influence) of Gene_expression (production) of IgG
3) Confidence 0.19 Published 2005 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 15698518 Disease Relevance 0.58 Pain Relevance 0.58
Hormonal status does not affect arthritis-induced increased levels of pro-inflammatory cytokines, IgG and CII antibodies
Neg (not) Regulation (affect) of Gene_expression (levels) of IgG in CII associated with inflammation, cytokine and arthritis
4) Confidence 0.16 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175035 Disease Relevance 1.34 Pain Relevance 0.45
On day 21, the impairment of humoral responses was more pronounced with respect to influenza as compared with the pneumococcal vaccine and affected both IgG and light-chain production.
Regulation (affected) of Gene_expression (production) of IgG associated with influenza virus infection
5) Confidence 0.13 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2911904 Disease Relevance 0.84 Pain Relevance 0.21
Ultralow concentrations of proenkephalin and [met5]-enkephalin differentially affect IgM and IgG production by B cells.
Regulation (affect) of Gene_expression (production) of IgG in B cells associated with enkephalin
6) Confidence 0.11 Published 1997 Journal J. Neuroimmunol. Section Title Doc Link 9058757 Disease Relevance 0 Pain Relevance 0.68
Effects of nano particles on adjuvant activity for total IgE and antigen-specific production of IgG and IgE
Regulation (Effects) of Gene_expression (production) of IgG
7) Confidence 0.09 Published 2005 Journal Respir Res Section Body Doc Link PMC1242256 Disease Relevance 0 Pain Relevance 0
Relationship between R0-GLURP IgG levels and Plasmodium falciparum density in Mgome (high transmission village)
Regulation (Relationship) of Gene_expression (levels) of IgG associated with malaria
8) Confidence 0.07 Published 2005 Journal Malar J Section Body Doc Link PMC1262760 Disease Relevance 0.10 Pain Relevance 0
Lagged analysis of the longitudinal data showed that salivary IgA and IgG levels were primarily affected by the number of respiratory infections in the preceding 2 months.
Regulation (affected) of Gene_expression (levels) of IgG in respiratory associated with lower respiratory tract infection
9) Confidence 0.05 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC3017893 Disease Relevance 0.67 Pain Relevance 0
Patient 2 showed no relevant variations regarding IgG and IgA levels.
Neg (no) Regulation (regarding) of Gene_expression (levels) of IgG
10) Confidence 0.03 Published 2009 Journal The Open Rheumatology Journal Section Body Doc Link PMC2684711 Disease Relevance 0.38 Pain Relevance 0.03

General Comments

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