INT68244

Context Info Confidence 0.61 First Reported 1997 Last Reported 2010 Negated 2 Speculated 0 Reported most in Body Documents 60 Total Number 60 Disease Relevance 48.86 Pain Relevance 5.01

extracellular space (Ighg1)

Anatomy Link Frequency salivary glands 4 lacrimal 4 glands 3 bars 2 plasma cells 1 Ighg1 (Mus musculus)

Pain Link Frequency Relevance Heat narcan 10 99.88 corticosteroid 28 99.00 Crohn's disease 50 98.08 diclofenac 22 97.42 fibrosis 33 97.04 Inflammation 300 96.40 cytokine 332 96.00 imagery 18 95.92 rheumatoid arthritis 138 95.44 Enkephalin 7 95.04

Disease Link Frequency Relevance Heat Immunization 531 99.98 Sprains And Strains 219 99.98 Disease 1682 99.84 Inflammatory Bowel Disease 39 99.52 Cold Sores 7 99.48 Anaphylaxis 6 99.44 Salivary Gland Disease 197 99.42 Aspergillus Infection 46 99.28 Disorders Of The Lacrimal System 351 99.02 Pressure And Volume Under Development 293 98.70

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

When 0.50 mg DF was co-injected with TNP-Ficoll, mice orally pretreated with DF, compared to vehicle-pretreated mice, and had a significantly greater increase in IgM anti-TNP AFCs on day 4, and a significant increase in both IgG1 and IgG3 anti-TNP AFCs on day 7.

Positive_regulation (increase) of IgG1 associated with diclofenac

1) Confidence 0.61 Published 2002 Journal Toxicology Section Abstract Doc Link 11893420 Disease Relevance 0 Pain Relevance 0.53

NLX also increased the IgG2a/IgG1 ratio, though it did not affect the production of HSV-1 antiserum.

Positive_regulation (increased) of IgG1 associated with cold sores and narcan

2) Confidence 0.49 Published 2009 Journal Int. Immunol. Section Abstract Doc Link 19174474 Disease Relevance 1.01 Pain Relevance 0.51

We have generated an immunoglobulin G1 (IgG1) murine monoclonal anti-idiotype antibody (Ab2) designated ACA125, which mimics a specific epitope on the tumor-associated antigen CA125.

Positive_regulation (generated) of immunoglobulin G1 associated with cancer

3) Confidence 0.47 Published 1997 Journal Hybridoma Section Abstract Doc Link 9085126 Disease Relevance 0.70 Pain Relevance 0

Microneedle vaccination without trehalose (MN) induced moderately high levels of IgG1 antibody as a dominant isotype in this group.

Positive_regulation (induced) of IgG1

4) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745577 Disease Relevance 0.81 Pain Relevance 0.09

In contrast, PENK induced no change in the production of Ig isotypes at any time point of addition, with the exception of IgG1 and IgG2a that were enhanced when PENK was added 6 h after cell activation.

Positive_regulation (enhanced) of IgG1

5) Confidence 0.44 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9058757 Disease Relevance 0 Pain Relevance 0.43

In the present study, the combined intratracheal administration of 14 nm nano particles and antigen showed a significant greater increase in total IgE and antigen-specific IgG1 and IgE than the other administration.

Positive_regulation (increase) of IgG1

6) Confidence 0.43 Published 2005 Journal Respir Res Section Body Doc Link PMC1242256 Disease Relevance 0.49 Pain Relevance 0.15

On day 21, anti-OVA IgG2a and interferon (IFN)-gamma as indicators of Th1 responses and anti-OVA IgG1 and interleukin (IL)-10 as those of Th2 responses were measured.

Positive_regulation (indicators) of IgG1

7) Confidence 0.42 Published 2005 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 15698518 Disease Relevance 0.34 Pain Relevance 0.45

Increases in serum IgG1 antibodies were also prominent in the group immunized by microneedle delivery after challenge infection (p<0.005 between MN and IM or IM+T for IgG1, Fig. 7B).

Positive_regulation (Increases) of IgG1 associated with immunization and infection

8) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745577 Disease Relevance 0.92 Pain Relevance 0.03

Our study demonstrates that CTH1/CAF01 vaccination induced high levels of CTH1 specific IgG1 and IgG2a both in blood and vaginal secretions.

Positive_regulation (levels) of IgG1 in blood

9) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2874006 Disease Relevance 0.41 Pain Relevance 0

Anticollagen IgG2a (regarded as a marker for a Th1 response) was reduced, and there was an increase in IgG1 (regarded as a marker for a Th2 response).

Positive_regulation (increase) of IgG1

10) Confidence 0.41 Published 2002 Journal Arthritis Res Section Body Doc Link PMC153843 Disease Relevance 0.57 Pain Relevance 0.09

Taken together, an increase in the IgG1:IgG2a ratio was observed, which may indicate a modulation of a Th1 to a Th2 immune response.

Positive_regulation (increase) of IgG1

11) Confidence 0.41 Published 2002 Journal Arthritis Res Section Body Doc Link PMC153843 Disease Relevance 0.60 Pain Relevance 0.12

With respect to the photooxidized human grafts, two of the seven mice showed high specific IgG1 titers, and one additional mouse showed an elevated IgG1 level.

Positive_regulation (elevated) of IgG1

12) Confidence 0.38 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1459156 Disease Relevance 0 Pain Relevance 0.04

Bovine collagen-specific total IgG, IgG1 and IgG2a antibodies were not induced by the unprocessed or photooxidized bovine osteochondral grafts at either four or twelve weeks.

Neg (not) Positive_regulation (induced) of IgG1

13) Confidence 0.38 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1459156 Disease Relevance 0 Pain Relevance 0.03

However, a weak IgG1 response was generated by four weeks after implantation with the photooxidized human graft, with a further increase in IgG1 levels at twelve weeks.

Positive_regulation (increase) of IgG1

14) Confidence 0.38 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1459156 Disease Relevance 0 Pain Relevance 0.04

Applying plain DT by M-TCI induced the same IgG1/IgG2a ratio as by s.c. injection.

Positive_regulation (induced) of IgG1 associated with immunization

15) Confidence 0.38 Published 2009 Journal Pharm Res Section Body Doc Link PMC2689355 Disease Relevance 0.30 Pain Relevance 0

Plain DT and DT-alum induced an IgG1 biased response when delivered via s.c. injection.

Positive_regulation (induced) of IgG1

16) Confidence 0.38 Published 2009 Journal Pharm Res Section Body Doc Link PMC2689355 Disease Relevance 0.24 Pain Relevance 0

IgG1/IgG2a ratios were calculated only using IgG2a responders.

Positive_regulation (calculated) of IgG1

17) Confidence 0.38 Published 2009 Journal Pharm Res Section Body Doc Link PMC2689355 Disease Relevance 0.41 Pain Relevance 0

Similarly to our previous findings [12,17], Af sensitization resulted in markedly increased serum IgE, IgG1 and IgG2a levels.

Positive_regulation (increased) of IgG1 associated with aspergillus infection

18) Confidence 0.38 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 1.27 Pain Relevance 0.04

In confirmation with others [16,17], we show an increase in Mycobacteria-specific IgG1 and IgG2 Abs in sera from patients with active CD or UC.

Positive_regulation (increase) of IgG1 associated with crohn's disease

19) Confidence 0.37 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 1.43 Pain Relevance 0.28

The induced levels of OVA-specific IgG1 appeared to be about 10 times higher in the surviving NIH mice than in BALB/cA mice (Figure 1B and 1E).

Positive_regulation (induced) of IgG1

20) Confidence 0.36 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1182367 Disease Relevance 0.88 Pain Relevance 0.07

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