INT68245

Context Info Confidence 0.38 First Reported 1997 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 1.78 Pain Relevance 1.73

Anatomy Link Frequency CII 2 IgG2a (Mus musculus)

Pain Link Frequency Relevance Heat Arthritis 90 99.48 Enkephalin 7 98.00 cINOD 5 97.68 dexamethasone 5 94.80 methotrexate 5 94.40 Inflammation 35 86.64 rheumatoid arthritis 76 84.24 cytokine 25 72.92 agonist 8 72.16 transdermal 7 50.00

Disease Link Frequency Relevance Heat Arthritis 90 99.48 INFLAMMATION 48 92.92 Immunization 60 88.44 Rheumatoid Arthritis 78 84.24 Influenza Virus Infection 35 82.96 Pressure And Volume Under Development 8 75.52 Autoimmune Disease 18 58.04 Graft Vs Host Disease 3 34.08 Infection 5 31.04 Disease 36 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Administration of indomethacin resulted in suppression of antigen (OVA)-induced arthritis that was associated with inhibition of anti-OVA IgG2a but not IgG1 production.

Negative_regulation (inhibition) of Gene_expression (production) of IgG2a associated with arthritis

1) Confidence 0.38 Published 2003 Journal J Pharm Sci Section Abstract Doc Link 12884258 Disease Relevance 0.33 Pain Relevance 0.38

Administrations of all the drugs used resulted in suppression of antigen (OVA)-induced arthritis in mice which was associated with inhibition of anti-OVA IgG2a but not IgG1 production.

Negative_regulation (inhibition) of Gene_expression (production) of IgG2a associated with arthritis

2) Confidence 0.36 Published 2005 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 15698518 Disease Relevance 0.62 Pain Relevance 0.57

Results show that proliferation was not affected by either peptide, but that IgM, IgG3 and IgG2a production were inhibited in a concentration- and time-dependent manner by MENK.

Negative_regulation (inhibited) of Gene_expression (production) of IgG2a associated with enkephalin

3) Confidence 0.25 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9058757 Disease Relevance 0 Pain Relevance 0.45

production after IM vaccination is consistent with the heightened Th1-like response indicated by the reduced IgG1/IgG2a ratio in the IM groups, since IFN-?

Negative_regulation (reduced) of Gene_expression (ratio) of IgG2a

4) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651574 Disease Relevance 0.16 Pain Relevance 0

Furthermore, B7-H4Ig plasmid treatment suppressed the production of total IgG (Figure 5C) and IgG1, IgG2a, and IgG2b autoantibodies to CII (Figure S7).

Negative_regulation (suppressed) of Gene_expression (production) of IgG2a in CII

5) Confidence 0.17 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 0.68 Pain Relevance 0.30

In addition, one mouse exhibited high IgG2a production after twelve weeks.

Negative_regulation (exhibited) of Gene_expression (production) of IgG2a

6) Confidence 0.10 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1459156 Disease Relevance 0 Pain Relevance 0.04

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