INT68247

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Context Info
Confidence 0.65
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 1.76
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Ighg3) cellular_component (Ighg3) biological_process (Ighg3)
Anatomy Link Frequency
plasma 1
T cell 1
Ighg3 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 7 97.40 Very High Very High Very High
Immobilon 1 89.84 High High
Morphine 4 88.88 High High
anesthesia 2 29.52 Quite Low
narcan 1 25.00 Low Low
isoflurane 1 5.12 Low Low
cytokine 38 5.00 Very Low Very Low Very Low
Inflammation 18 5.00 Very Low Very Low Very Low
chemokine 13 5.00 Very Low Very Low Very Low
agonist 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 98 99.70 Very High Very High Very High
Mitral Valve Prolapse 36 97.60 Very High Very High Very High
Vesicular Stomatitis 2 78.32 Quite High
Pressure And Volume Under Development 4 73.16 Quite High
Sprains And Strains 59 71.44 Quite High
General Immunology 6 69.40 Quite High
Immunization 57 66.68 Quite High
Splenomegaly 1 54.44 Quite High
American Trypanosomiasis 2 50.00 Quite Low
Autoimmune Disease 26 48.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
500), mouse IgG3 anti-MoPn-40 (1?
Gene_expression (anti) of IgG3
1) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671841 Disease Relevance 0.27 Pain Relevance 0.04
Results show that proliferation was not affected by either peptide, but that IgM, IgG3 and IgG2a production were inhibited in a concentration- and time-dependent manner by MENK.
Gene_expression (production) of IgG3 associated with enkephalin
2) Confidence 0.50 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9058757 Disease Relevance 0 Pain Relevance 0.45
Subclass determination showed that the clones produced IgG1, IgG2a, IgG3, and IgM types of antibody.
Gene_expression (produced) of IgG3
3) Confidence 0.39 Published 2002 Journal Hybrid. Hybridomics Section Abstract Doc Link 12165146 Disease Relevance 0.07 Pain Relevance 0.29
Later in the course of infection, (day 35–40 post-infection) IgG1, IGg2b, IgG3, and IgA were produced.
Gene_expression (produced) of IgG3 associated with infection
4) Confidence 0.26 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2852613 Disease Relevance 1.28 Pain Relevance 0
TI-2 antigens elicit robust IgM and IgG3 antibody production in a TI fashion, although the presence of noncognate T cell help promotes production of other IgG isotypes (Mongini et al., 1984).
Gene_expression (production) of IgG3 in T cell
5) Confidence 0.26 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2901065 Disease Relevance 0.08 Pain Relevance 0
The plasma levels of IgM, IgG1, IgG2a, IgG2b, IgG3, and IgA were determined simultaneously in the same sample using a bead-based assay with monoclonal anti-mouse antibodies conjugated to beads of different color regions (Biorad, USA), and acquired on a Bioplex reader (Biorad).
Spec (determined) Gene_expression (levels) of IgG3 in plasma
6) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0.07 Pain Relevance 0
The hydrolytic anti-DNA antibodies were reported to be IgG1 and IgG3 classes.
Gene_expression (classes) of IgG3
7) Confidence 0.18 Published 2010 Journal Autoimmune Diseases Section Body Doc Link PMC2989704 Disease Relevance 0 Pain Relevance 0

General Comments

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