INT68248

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Context Info
Confidence 0.61
First Reported 1997
Last Reported 2008
Negated 1
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.02
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ighg1)
Ighg1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 50 99.32 Very High Very High Very High
Osteoarthritis 21 99.04 Very High Very High Very High
Enkephalin 7 95.56 Very High Very High Very High
cytokine 45 80.72 Quite High
anesthesia 3 38.52 Quite Low
narcan 1 25.00 Low Low
Inflammation 7 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 50 99.32 Very High Very High Very High
Frailty 22 99.04 Very High Very High Very High
Lewis Lung Carcinoma 136 96.76 Very High Very High Very High
Sprains And Strains 49 95.56 Very High Very High Very High
Infection 30 91.52 High High
Cancer 73 80.36 Quite High
Disease 8 75.16 Quite High
Anaerobic Bacterial Infections 5 68.52 Quite High
Hypersensitivity 15 50.00 Quite Low
Lung Cancer 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, PENK induced no change in the production of Ig isotypes at any time point of addition, with the exception of IgG1 and IgG2a that were enhanced when PENK was added 6 h after cell activation.
Neg (exception) Transcription (exception) of IgG1
1) Confidence 0.61 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9058757 Disease Relevance 0 Pain Relevance 0.43
IgE, IgG1 and IgG2a anti-OVA antibodies were detected in a capture ELISAs as previously described [19,53], as modified in [54].
Transcription (detected) of IgG1
2) Confidence 0.41 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1182367 Disease Relevance 0.24 Pain Relevance 0.04
mRNA expression levels, and serum IgG1 and IgG2a titers as compared to TG-injected mice.
Transcription (expression) of IgG1
3) Confidence 0.29 Published 2007 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2694397 Disease Relevance 1.07 Pain Relevance 0
To distinguish between these two possibilities, qPCR was used to determine mRNA levels for constant regions of IgM and IgG1 heavy chains in RA and OA synovia.
Spec (determine) Transcription (levels) of IgG1 associated with rheumatoid arthritis and osteoarthritis
4) Confidence 0.21 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592782 Disease Relevance 1.71 Pain Relevance 0.79

General Comments

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