INT68255

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Context Info
Confidence 0.41
First Reported 1997
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 5.71
Pain Relevance 3.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL8) extracellular space (IL8) extracellular region (IL8)
intracellular (IL8)
Anatomy Link Frequency
neutrophils 6
THP-1 2
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 17 99.76 Very High Very High Very High
Calcitonin gene-related peptide 12 99.60 Very High Very High Very High
Morphine 206 99.30 Very High Very High Very High
Inflammation 113 99.28 Very High Very High Very High
Paracetamol 3 98.98 Very High Very High Very High
antagonist 10 98.60 Very High Very High Very High
chemokine 17 97.68 Very High Very High Very High
Opioid 10 97.24 Very High Very High Very High
cytokine 246 97.08 Very High Very High Very High
Neuropeptide 3 87.12 High High
Disease Link Frequency Relevance Heat
Infection 50 99.32 Very High Very High Very High
INFLAMMATION 138 99.28 Very High Very High Very High
Sprains And Strains 178 99.16 Very High Very High Very High
Overdose 2 99.16 Very High Very High Very High
Disease 44 98.62 Very High Very High Very High
Solid Tumor 1 98.06 Very High Very High Very High
Nicotine Addiction 10 97.12 Very High Very High Very High
Reprotox - General 1 54 95.28 Very High Very High Very High
Hypoxia 11 95.16 Very High Very High Very High
Malignant Neoplastic Disease 12 92.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CGRP stimulation had no effect on the half-life of IL-8 mRNA while increasing IL-8 pre-mRNA synthesis >2-fold.
Neg (no) Regulation (effect) of Positive_regulation (half-life) of IL-8 associated with calcitonin gene-related peptide
1) Confidence 0.41 Published 2000 Journal J. Immunol. Section Abstract Doc Link 10754330 Disease Relevance 0.15 Pain Relevance 0.80
A study of acetaminophen overdose in a clinical population demonstrated an increase in IL8, IL6, and MCP-1 in the most severely affected patients (based on serum ALT), yet only MCP-1 had a good correlation (R2 = 0.607) over the range of severity (James et al., 2005).
Regulation (affected) of Positive_regulation (increase) of IL8 associated with paracetamol and overdose
2) Confidence 0.34 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2923281 Disease Relevance 0.41 Pain Relevance 0.49
In conclusion, the present results demonstrate that human neutrophils secrete morphine via a Ca2+-dependent mechanism in response to LPS or IL-8 stimulation.


Regulation (response) of Positive_regulation (stimulation) of IL-8 in neutrophils associated with morphine
3) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808358 Disease Relevance 0 Pain Relevance 0.91
Figure 5A shows that ISO photochemical products induced a greater change in IL-8 expression (IL-8 protein induced) compared with clean air control.
Regulation (change) of Positive_regulation (induced) of IL-8
4) Confidence 0.27 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
Whilst smoking cessation and abstinence provide the best approach for the treatment of this disease the pharmaceutical industry are developing molecules which target a number of mediators including LTB4, IL-8, TNF-?
Regulation (number) of Positive_regulation (mediators) of IL-8 associated with nicotine addiction and disease
5) Confidence 0.19 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695611 Disease Relevance 1.62 Pain Relevance 0.38
In stimulated monocytic cells (THP-1), lornoxicam showed a marked inhibition of IL-6 formation (IC50 54 microM) while the formation ofTNF-alpha, IL-1beta and IL-8 was only moderately affected.
Regulation (affected) of Positive_regulation (formation) of IL-8 in THP-1
6) Confidence 0.17 Published 1999 Journal Inflamm. Res. Section Body Doc Link 10450786 Disease Relevance 0 Pain Relevance 0
This IL-8 induction was dependent on the AR as the inhibition of AR expression by siRNA prevented IL-8 secretion following androgen stimulation (Figure 5C).
Regulation (dependent) of Positive_regulation (induction) of IL-8
7) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.37 Pain Relevance 0.15
2-integrins on neutrophils upon IL-8 or LTB4 stimulation
Regulation (integrins) of Positive_regulation (stimulation) of IL-8 in neutrophils
8) Confidence 0.10 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2020438 Disease Relevance 0.13 Pain Relevance 0.04
2-integrin up-regulation on neutrophils upon IL-8 or LTB4 stimulation
Regulation (regulation) of Positive_regulation (stimulation) of IL-8 in neutrophils
9) Confidence 0.10 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2020438 Disease Relevance 0.33 Pain Relevance 0.12
Growth of solid tumors is a multistage process that begins with an avascular stage followed by a vascular phase, which depends on the induction of angiogenic factors VEGF and IL-8.
Regulation (depends) of Positive_regulation (induction) of IL-8 associated with solid tumor
10) Confidence 0.06 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923369 Disease Relevance 1.13 Pain Relevance 0.16
In both groups, surgery evoked the expected glucose, cortisol and interleukin-6 response but no increase in interleukin-8 was detected.
Regulation (response) of Neg (no) Positive_regulation (increase) of interleukin-8
11) Confidence 0.05 Published 1997 Journal Anaesthesia Section Abstract Doc Link 9059091 Disease Relevance 0 Pain Relevance 0.21
We examined the effects of the supplementation of inhalational anaesthesia with either 3 or 15 micrograms.kg-1 fentanyl on the circulating interleukin-6, interleukin-8, C-reactive protein, cortisol and glucose concentrations in 16 patients undergoing pelvic surgery.
Spec (examined) Regulation (effects) of Positive_regulation (circulating) of interleukin-8
12) Confidence 0.05 Published 1997 Journal Anaesthesia Section Abstract Doc Link 9059091 Disease Relevance 0 Pain Relevance 0.20
In addition, a previous study has demonstrated that the induction of CXCL8 from INT407 cells may be regulated by two independent mechanisms, one of which requires adherence and/or invasion and the other requires cytolethal distending toxin (CDT) [29].
Spec (may) Regulation (regulated) of Positive_regulation (induction) of CXCL8
13) Confidence 0.05 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2443369 Disease Relevance 0.65 Pain Relevance 0.38
This secondary IL-8 induction was not affected by deletion of this strain's TnPZ (Fig. 6B), and thus may be due to another virulence determinant, such as the oipA or homB genes [45], [46].
Neg (not) Regulation (affected) of Positive_regulation (induction) of IL-8 associated with sprains and strains
14) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731543 Disease Relevance 0.93 Pain Relevance 0.06

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