INT6826

Context Info Confidence 0.71 First Reported 1987 Last Reported 2010 Negated 1 Speculated 5 Reported most in Abstract Documents 130 Total Number 135 Disease Relevance 22.19 Pain Relevance 54.88

extracellular region (Pdyn) plasma membrane (Pdyn)

Anatomy Link Frequency hippocampus 12 striatum 11 brain 8 nucleus accumbens 7 Fat 5 Pdyn (Rattus norvegicus)

Pain Link Frequency Relevance Heat Enkephalin 228 100.00 Dynorphin 227 100.00 Opioid 129 100.00 mu opioid receptor 9 100.00 Cholecystokinin 6 100.00 Hippocampus 72 99.90 Morphine 41 99.82 Kappa opioid receptor 27 99.80 cocaine 68 99.72 Dopamine 161 99.68

Disease Link Frequency Relevance Heat Diabetes Mellitus 22 100.00 Generalized Anxiety Disorder 10 100.00 Shock 24 99.82 Pain 9 99.66 Convulsion 61 99.54 Hyperphagia 9 99.52 Epilepsy 16 99.32 Sprains And Strains 6 99.26 Partial Seizures 6 99.00 Cancer 2 98.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

When compared with data from the literature, our results suggest that translation may immediately follow transcription of prodynorphin gene in the supraoptic nucleus.

Transcription (transcription) of prodynorphin gene in supraoptic nucleus

1) Confidence 0.71 Published 1993 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 8222211 Disease Relevance 0 Pain Relevance 0.16

Our results show an increase in the PDYN mRNA level in the CEA and NAcc shell and no changes of PENK gene expression after heroin self-administration.

Transcription (level) of PDYN in NAcc associated with nucleus accumbens and amygdala

2) Confidence 0.71 Published 2009 Journal Brain Res. Section Abstract Doc Link 19100723 Disease Relevance 0 Pain Relevance 0.51

The amounts of prodynorphin mRNA (DYN mRNA) and proenkephalin A mRNA (EK mRNA) in the hippocampus and entorhinal cortex were measured by RNA blot analysis.

Transcription (amounts) of prodynorphin in hippocampus associated with hippocampus

3) Confidence 0.69 Published 1990 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1970844 Disease Relevance 0.09 Pain Relevance 0.36

The effect of cycloheximide (CHX), a protein synthesis inhibitor, on the regulation of proenkephalin (proENK) and prodynorphin (proDYN) mRNA levels, proto-oncogenes, such as c-fos, 35-kDa fra and c-jun mRNA, and the levels of their products induced by kainic acid (KA) in rat hippocampus was studied.

Transcription (levels) of prodynorphin in hippocampus associated with hippocampus

4) Confidence 0.69 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221929 Disease Relevance 0 Pain Relevance 0.08

Both Northern blot and in situ hybridization methods were used to examine the proenkephalin (PENK) and prodynorphin (PDYN) mRNA levels in the rat hippocampus.

Spec (examine) Transcription (levels) of prodynorphin in hippocampus associated with hippocampus

5) Confidence 0.69 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9179861 Disease Relevance 0.44 Pain Relevance 0.77

Both Northern blot and in situ hybridization methods were used to examine the proenkephalin (PENK) and prodynorphin (PDYN) mRNA levels in the rat hippocampus.

Spec (examine) Transcription (levels) of PDYN in hippocampus associated with hippocampus

6) Confidence 0.69 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9179861 Disease Relevance 0.44 Pain Relevance 0.77

These observations suggest that, at variance with other experimental situations, Fos is not involved in the mechanisms of kindled seizure-induced activation of prodynorphin transcription in the rat forebrain.

Transcription (transcription) of prodynorphin in forebrain associated with convulsion

7) Confidence 0.69 Published 1996 Journal Eur. J. Neurosci. Section Abstract Doc Link 8921296 Disease Relevance 0.25 Pain Relevance 0.04

This study examined behavioral responses and the expression of preprodynorphin (PPD) mRNA at the spinal level during complete Freund's adjuvant-induced inflammation of the unilateral hind paw in male Fischer 344 (F344), Sprague-Dawley (SD), and Lewis (LEW) rats.

Transcription (expression) of preprodynorphin in paw associated with inflammation

8) Confidence 0.69 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14665419 Disease Relevance 0.49 Pain Relevance 0.43

The aim of the present study was to determine whether (1S,3R,4S)-1-aminocyclo-pentane-1,3,4-tricarboxylic acid (ACPT-1), an agonist of group III mGluRs, injected bilaterally into the globus pallidus (GP), striatum or substantia nigra pars reticulata (SNr), can attenuate the haloperidol-induced catalepsy in rats, and whether that effect was related to modulation of proenkephalin (PENK) or prodynorphin (PDYN) mRNA expression in the striatum.

Transcription (expression) of prodynorphin in striatum associated with catalepsy, substantia nigra and agonist

9) Confidence 0.69 Published 2007 Journal Neuroscience Section Abstract Doc Link 17224239 Disease Relevance 0.42 Pain Relevance 0.17

The aim of the present study was to determine whether (1S,3R,4S)-1-aminocyclo-pentane-1,3,4-tricarboxylic acid (ACPT-1), an agonist of group III mGluRs, injected bilaterally into the globus pallidus (GP), striatum or substantia nigra pars reticulata (SNr), can attenuate the haloperidol-induced catalepsy in rats, and whether that effect was related to modulation of proenkephalin (PENK) or prodynorphin (PDYN) mRNA expression in the striatum.

Transcription (expression) of PDYN in striatum associated with catalepsy, substantia nigra and agonist

10) Confidence 0.69 Published 2007 Journal Neuroscience Section Abstract Doc Link 17224239 Disease Relevance 0.42 Pain Relevance 0.17

At 3 h after the last dose of imipramine the prodynorphin mRNA level was decreased (by ca. 25%) in the striatum, but not in the nucleus accumbens, whereas at 24 h an up-regulation (by ca. 27%) of prodynorphin mRNA level could be observed in the nucleus accumbens only.

Transcription (level) of prodynorphin mRNA in nucleus accumbens associated with nucleus accumbens

11) Confidence 0.69 Published 1997 Journal Pol J Pharmacol Section Abstract Doc Link 9566035 Disease Relevance 0 Pain Relevance 0.41

In order to elucidate the activity of the endogenous prodynorphin system during opiate tolerance and dependence, we investigated the effect of single and repeated morphine administration on the alpha-neoendorphin tissue level, its in vitro release, and the prodynorphin messenger RNA level in the nucleus accumbens and striatum of the rat.

Transcription (level) of prodynorphin messenger RNA in striatum associated with nucleus accumbens, addiction, tolerance, opiate and morphine

12) Confidence 0.69 Published 1996 Journal Neuroscience Section Abstract Doc Link 9045086 Disease Relevance 0 Pain Relevance 1.06

While proenkephalin mRNA was widely distributed throughout the striatum, levels of prodynorphin mRNA were highest in the medial and ventral portions of the striatum.

Transcription (distributed) of proenkephalin mRNA in ventral

13) Confidence 0.69 Published 1989 Journal J. Mol. Neurosci. Section Abstract Doc Link 2561993 Disease Relevance 0 Pain Relevance 0.32

Within the L-DOPA-treated group, levels of preproenkephalin (PPE) mRNA, glutamic acid decarboxylase (GAD67) mRNA, and prodynorphin (PDyn) mRNA in the dopamine-denervated caudate-putamen, as well as GAD67 mRNA expression in the globus pallidus ipsilateral to the 6-hydroxydopamine (6-OHDA) lesion, were higher in dyskinetic than non-dyskinetic animals, and positively correlated with the rats' dyskinesia scores.

Transcription (mRNA) of PDyn in globus pallidus associated with dopamine and dyskinesias

14) Confidence 0.69 Published 1998 Journal Eur. J. Neurosci. Section Abstract Doc Link 9767399 Disease Relevance 0.32 Pain Relevance 0.12

Within the L-DOPA-treated group, levels of preproenkephalin (PPE) mRNA, glutamic acid decarboxylase (GAD67) mRNA, and prodynorphin (PDyn) mRNA in the dopamine-denervated caudate-putamen, as well as GAD67 mRNA expression in the globus pallidus ipsilateral to the 6-hydroxydopamine (6-OHDA) lesion, were higher in dyskinetic than non-dyskinetic animals, and positively correlated with the rats' dyskinesia scores.

Transcription (mRNA) of prodynorphin in globus pallidus associated with dopamine and dyskinesias

15) Confidence 0.69 Published 1998 Journal Eur. J. Neurosci. Section Abstract Doc Link 9767399 Disease Relevance 0.32 Pain Relevance 0.12

In the present study, involvement of Fos in the mechanism of the PENK and PDYN gene induction in the hippocampal dentate gyrus during seizures elicited by kainic acid was studied using a knock-down technique.

Transcription (mechanism) of PDYN gene in dentate gyrus associated with targeted disruption and convulsion

16) Confidence 0.68 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9555037 Disease Relevance 0.35 Pain Relevance 0.07

Evidence from the Northern blot analysis reveals that lithium increases the prodynorphin mRNA abundance in the striatum.

Transcription (abundance) of prodynorphin mRNA in striatum

17) Confidence 0.67 Published 1988 Journal Brain Res. Section Abstract Doc Link 2898269 Disease Relevance 0 Pain Relevance 0.26

The effect of L-arginine (L-ARG), a nitric oxide donor, or Nomega-nitro-L-arginine (L-NAME), a nitric oxide synthase inhibitor, on the regulation of kainic acid (KA)-induced proenkephalin (proENK) and prodynorphin (proDYN) mRNA expressions in rat hippocampus was studied.

Transcription (expressions) of prodynorphin in hippocampus associated with hippocampus

18) Confidence 0.67 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602069 Disease Relevance 0 Pain Relevance 0.09

The distribution of prodynorphin (proDyn) messenger RNA (mRNA) was examined in the rat pituitary using Northern and in situ hybridization analysis.

Spec (examined) Transcription (distribution) of prodynorphin in pituitary

19) Confidence 0.67 Published 1993 Journal Endocrinology Section Abstract Doc Link 8243288 Disease Relevance 0 Pain Relevance 0.06

The effects of deep prepyriform cortex (DPC) kindling on the amount of proenkephalin and prodynorphin mRNAs, Met5-enkephalin (ME) and dynorphin (DYN) in rat brain were examined.

Transcription (amount) of prodynorphin in DPC associated with dynorphin and enkephalin

20) Confidence 0.67 Published 1989 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 2593781 Disease Relevance 0.90 Pain Relevance 0.53

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