INT68265

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Context Info
Confidence 0.46
First Reported 1997
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.08
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs2) nuclear envelope (Ptgs2) oxidoreductase activity (Ptgs2)
endoplasmic reticulum (Ptgs2) nucleus (Ptgs2) enzyme binding (Ptgs2)
Anatomy Link Frequency
plasma 2
uterine 2
Ptgs2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
acular 5 100.00 Very High Very High Very High
Potency 2 98.14 Very High Very High Very High
Paracetamol 1 87.12 High High
Dismenorea 1 84.04 Quite High
cytokine 5 75.00 Quite High
Cannabinoid receptor 1 67.48 Quite High
agonist 1 65.56 Quite High
Cannabinoid 1 65.24 Quite High
COX-2 inhibitor 1 62.00 Quite High
aspirin 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Dysmenorrhea 1 84.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The potency of ibuprofen as an inhibitor of anandamide metabolism was of the same order of magnitude as required for inhibition of cyclooxygenase-2 in cell-free systems and of the peak plasma concentrations of this drug following a 2 x 200 mg dose regimen.
Positive_regulation (required) of Negative_regulation (inhibition) of cyclooxygenase-2 in plasma associated with potency
1) Confidence 0.46 Published 1997 Journal Pharmacol. Toxicol. Section Abstract Doc Link 9060042 Disease Relevance 0 Pain Relevance 0.27
Cyclooxygenase-2 inhibition increases gastric tone and delays gastric emptying in rats.
Positive_regulation (increases) of Negative_regulation (inhibition) of Cyclooxygenase-2 associated with acular
2) Confidence 0.39 Published 2007 Journal Neurogastroenterol. Motil. Section Title Doc Link 17300293 Disease Relevance 0 Pain Relevance 0.44
By day 21, the control animals had significant increases (P < or = 0.05) in mRNA for OT, FP, PGHS2, and Cx-43, a decrease (P < or = 0.05) in iNOS, and an increase (P < or = 0.05) in uterine sensitivity and responsiveness to OT.
Positive_regulation (increases) of Negative_regulation (decrease) of PGHS2 in uterine
3) Confidence 0.05 Published 2005 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 15870103 Disease Relevance 0.08 Pain Relevance 0.22

General Comments

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