INT68269

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Context Info
Confidence 0.77
First Reported 1997
Last Reported 2010
Negated 12
Speculated 0
Reported most in Abstract
Documents 49
Total Number 49
Disease Relevance 47.38
Pain Relevance 3.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (CD99) plasma membrane (CD99) cytoplasm (CD99)
Anatomy Link Frequency
smooth muscle 7
neuron 5
stroma 2
Thyroid 2
kidney 1
CD99 (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 11 98.96 Very High Very High Very High
vincristine 9 95.52 Very High Very High Very High
Pain 22 93.76 High High
backache 5 93.56 High High
abdominal pain 12 91.56 High High
Thoracotomy 2 90.44 High High
Central nervous system 11 89.44 High High
cva 10 89.04 High High
imagery 37 88.80 High High
Snapping jaw 1 85.12 High High
Disease Link Frequency Relevance Heat
Epstein-barr Virus 133 100.00 Very High Very High Very High
Infection 64 100.00 Very High Very High Very High
Cancer 523 99.96 Very High Very High Very High
Nasopharynx Cancer 290 99.84 Very High Very High Very High
Synovial Sarcoma 30 99.66 Very High Very High Very High
Fatigue 23 99.24 Very High Very High Very High
Neuroendocrine Cancer 34 99.20 Very High Very High Very High
Sarcoma 120 99.04 Very High Very High Very High
Primitive Neuroectodermal Tumors 157 98.96 Very High Very High Very High
Headache 10 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical study revealed that the tumor cells expressed positivity against CD99 (MIC2), neuron-specific enolase, synaptophysin and vimentin.
Gene_expression (expressed) of MIC2 in neuron associated with cancer
1) Confidence 0.77 Published 2000 Journal Pathol. Int. Section Abstract Doc Link 10849329 Disease Relevance 0.42 Pain Relevance 0.08
Immunohistochemical study revealed that the tumor cells expressed positivity against CD99 (MIC2), neuron-specific enolase, synaptophysin and vimentin.
Gene_expression (expressed) of CD99 in neuron associated with cancer
2) Confidence 0.77 Published 2000 Journal Pathol. Int. Section Abstract Doc Link 10849329 Disease Relevance 0.42 Pain Relevance 0.08
Immunohistochemical stains on paraffin-embedded tissue showed that the neoplastic cells expressed terminal deoxynucleotidyl transferase, CD43, vimentin, and CD99 (MIC2 gene product) in all cases.
Gene_expression (expressed) of MIC2
3) Confidence 0.75 Published 1998 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 9669342 Disease Relevance 1.00 Pain Relevance 0.09
Some of the cells formed a rosette structure and the tumor cells were positive for CD99, leading to diagnosis of PNET.
Gene_expression (positive) of CD99 associated with cancer and primitive neuroectodermal tumors
4) Confidence 0.68 Published 2010 Journal Int. J. Clin. Oncol. Section Abstract Doc Link 20186557 Disease Relevance 1.18 Pain Relevance 0.17
Immunohistochemically, the tumor cells were positive for vimentin, CD 99, BCL-2 protein and EMA.
Gene_expression (positive) of CD 99 associated with cancer
5) Confidence 0.65 Published 2006 Journal Intern. Med. Section Abstract Doc Link 16778340 Disease Relevance 0.52 Pain Relevance 0.08
Immunohistochemical study showed that lipid-laden cells expressed EMA, CD99, and progesteron receptor, favoring a meningothelial differentiation rather than an adipocytic lineage.
Gene_expression (expressed) of CD99
6) Confidence 0.61 Published 2008 Journal Surg Neurol Section Abstract Doc Link 17825370 Disease Relevance 1.03 Pain Relevance 0.08
Cytokeratin (CK), glial fibrillary acidic protein (GFAP), CD34, Desmin, CD99 and S-100 were negative in both components of lesion.
Neg (negative) Gene_expression (negative) of CD99
7) Confidence 0.61 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2904739 Disease Relevance 0.62 Pain Relevance 0
The tumor cells were positive for CD99 and bcl-2 in all cases and for CD56 in two cases and negative for CD34 and smooth muscle actin in all cases.
Neg (negative) Gene_expression (positive) of CD99 in smooth muscle associated with cancer
8) Confidence 0.58 Published 2004 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 15105652 Disease Relevance 1.07 Pain Relevance 0.06
Immunohistochemical studies demonstrated positive immunoreactivity for neuron-specific enolase, synaptophysin, chromogranin, vimentin, S-100 protein and p30-32 MIC-2 gene product.
Gene_expression (product) of MIC-2 in neuron
9) Confidence 0.58 Published 2005 Journal Acta Otolaryngol. Section Abstract Doc Link 15823816 Disease Relevance 0.72 Pain Relevance 0.13
In our case the presence of MIC-2 gene products, known also as CD99, 12E7, E2, 013 and HBA71, suggested a PNET diagnosis.
Gene_expression (products) of MIC-2 associated with primitive neuroectodermal tumors
10) Confidence 0.58 Published 2004 Journal BMC Cancer Section Body Doc Link PMC331414 Disease Relevance 1.67 Pain Relevance 0.03
Immunohistochemical stains on paraffin-embedded tissue showed that the neoplastic cells expressed terminal deoxynucleotidyl transferase, CD43, vimentin, and CD99 (MIC2 gene product) in all cases.
Gene_expression (product) of MIC2
11) Confidence 0.58 Published 1998 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 9669342 Disease Relevance 0.97 Pain Relevance 0.09
All neoplastic cells were stained positive for MIC2-protein (CD99).
Gene_expression (positive) of CD99
12) Confidence 0.55 Published 2006 Journal World J. Gastroenterol. Section Abstract Doc Link 17009412 Disease Relevance 1.16 Pain Relevance 0.09
The antibodies used included CD99 (Dako, M3601), pankeratin (Dako, M0821), cytokeratin AE1/AE3 (Dako, M3515), vimentin (Dako, M7010), desmin (Dako, M0760), S100 (Dako, Z0311), and chromogranin A (Dako, M0869), at suggested dilution.
Gene_expression (included) of CD99
13) Confidence 0.52 Published 2004 Journal BMC Cancer Section Body Doc Link PMC331414 Disease Relevance 0.80 Pain Relevance 0.08
Immunohistochemical staining showed that the cells expressed neuroendocrine markers (synaptophysin, chromogranin, NSE) and cytokeratin marker (CAM 5.2) but were negative for S100, HMB45, CD99 and CD117.
Neg (negative) Gene_expression (negative) of CD99
14) Confidence 0.43 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1971059 Disease Relevance 0.76 Pain Relevance 0.07
Pilot study of LMP-1 and CD99 expressions in NPC suggested that the LMP-1 induced down-regulation of the CD99 pathway was important in nasopharyngeal carcinogenesis, and that the expression of CD99 in lymphoid stroma might regulate immune response to NPC [80].
Gene_expression (expressions) of CD99 in stroma associated with nasopharynx cancer
15) Confidence 0.40 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 0.96 Pain Relevance 0.03
Pilot study of LMP-1 and CD99 expressions in NPC suggested that the LMP-1 induced down-regulation of the CD99 pathway was important in nasopharyngeal carcinogenesis, and that the expression of CD99 in lymphoid stroma might regulate immune response to NPC [80].
Gene_expression (expression) of CD99 in stroma associated with nasopharynx cancer
16) Confidence 0.40 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 0.96 Pain Relevance 0.03
CD34 and CD99 were negative in all cases.
Neg (negative) Gene_expression (negative) of CD99
17) Confidence 0.38 Published 1999 Journal J. Korean Med. Sci. Section Abstract Doc Link 10576153 Disease Relevance 0.88 Pain Relevance 0.08
MIC2 gene product expression and EWS/ETS gene rearrangement were detected in both case patients.
Gene_expression (expression) of MIC2 gene
18) Confidence 0.36 Published 2006 Journal Hum. Pathol. Section Abstract Doc Link 16784984 Disease Relevance 0.78 Pain Relevance 0.23
Another defining characteristic of pPNETs/ESFTs is their membranous expression of the MIC2 gene product.
Gene_expression (expression) of MIC2 gene
19) Confidence 0.36 Published 2006 Journal Hum. Pathol. Section Abstract Doc Link 16784984 Disease Relevance 0.79 Pain Relevance 0.20
The both types of cells were positive for CD99.
Gene_expression (positive) of CD99
20) Confidence 0.28 Published 2008 Journal Auris Nasus Larynx Section Abstract Doc Link 18262374 Disease Relevance 0.40 Pain Relevance 0.09

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