INT68277

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Context Info
Confidence 0.56
First Reported 1997
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 6.98
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CXCL1) signal transduction (CXCL1) extracellular space (CXCL1)
extracellular region (CXCL1) intracellular (CXCL1)
Anatomy Link Frequency
limbs 2
endothelial cell 1
T cell 1
CXCL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 74 100.00 Very High Very High Very High
addiction 1 100.00 Very High Very High Very High
Arthritis 2 99.96 Very High Very High Very High
ischemia 21 99.66 Very High Very High Very High
chemokine 12 98.54 Very High Very High Very High
Pain 5 97.32 Very High Very High Very High
cINOD 2 96.56 Very High Very High Very High
rheumatoid arthritis 3 93.28 High High
cytokine 9 83.44 Quite High
Inflammatory mediators 2 81.72 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 77 100.00 Very High Very High Very High
Adhesions 1 100.00 Very High Very High Very High
Arthritis 3 99.96 Very High Very High Very High
Cv General 4 Under Development 8 99.84 Very High Very High Very High
Cv Unclassified Under Development 14 99.66 Very High Very High Very High
Colorectal Cancer 16 98.44 Very High Very High Very High
Increased Venous Pressure Under Development 6 98.12 Very High Very High Very High
Pain 5 97.32 Very High Very High Very High
Cancer 19 97.24 Very High Very High Very High
Fever 1 97.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results of this study confirm previous findings from animal models and humans, that CXCL1 is increased in cerebral ischemia [28].
Positive_regulation (increased) of CXCL1 associated with cv general 4 under development and ischemia
1) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2993950 Disease Relevance 1.26 Pain Relevance 0.45
Endothelins modulate inflammatory reaction in zymosan-induced arthritis: participation of LTB4, TNF-alpha, and CXCL-1.
Positive_regulation (participation) of CXCL-1 associated with chemokine, inflammation and arthritis
2) Confidence 0.49 Published 2008 Journal J. Leukoc. Biol. Section Title Doc Link 18515326 Disease Relevance 1.17 Pain Relevance 0.59
Wang et al. (2006) [18] reported that expression of CXCL1 induced by PGE2 was linked to angiogenesis in colorectal cancer in vitro and in vivo and thus provided a link between COX-2 up-regulation and chemokine induced tumour associated endothelial cell migration.
Positive_regulation (induced) of CXCL1 in endothelial cell associated with colorectal cancer, chemokine and cancer
3) Confidence 0.40 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017541 Disease Relevance 1.59 Pain Relevance 0.22
Critically ischemic limbs have increased FSP in the dependent position.
Positive_regulation (increased) of FSP in limbs
4) Confidence 0.19 Published 1997 Journal Ann Vasc Surg Section Abstract Doc Link 9061139 Disease Relevance 0.71 Pain Relevance 0.13
Limbs with critical ischemia demonstrated an increase in FSP with dependency (supine 4.0 +/- 1.0 ml/min/100 g) versus dependent (8.4 +/- 1.8 ml/min/100 g) and was present in both diabetic and nondiabetic limbs.
Positive_regulation (increase) of FSP in limbs associated with diabetes mellitus and ischemia
5) Confidence 0.11 Published 1997 Journal Ann Vasc Surg Section Abstract Doc Link 9061139 Disease Relevance 0.91 Pain Relevance 0.19
Therefore, we have used adenoviral overexpression to demonstrate NF-kappaB and IKK2 dependence of key inflammatory genes, including intercellular adhesion molecule (ICAM)-1, cyclooxygenase-2, IL-6, IL-8, granulocyte macrophage-colony-stimulating factor (GM-CSF), regulated on activation normal T cell expressed and secreted (RANTES), monocyte chemotactic protein-1 (MCP-1), growth-regulated oncogene-alpha (GROalpha), neutrophil-activating protein-2 (NAP-2), and epithelial neutrophil activating peptide 78 (ENA-78) in primary human airways smooth muscle cells.
Positive_regulation (dependence) of GROalpha in T cell associated with addiction, inflammation and adhesions
6) Confidence 0.08 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16687566 Disease Relevance 1.35 Pain Relevance 0.56

General Comments

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