INT68279

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Context Info
Confidence 0.67
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 30
Total Number 31
Disease Relevance 16.31
Pain Relevance 6.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Csf2) extracellular region (Csf2)
Anatomy Link Frequency
cervical lymph nodes 9
granulocyte 6
hepatocytes 4
CSF 4
tubes 4
Csf2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 108 100.00 Very High Very High Very High
cva 56 100.00 Very High Very High Very High
Neuropathic pain 5 99.98 Very High Very High Very High
Central nervous system 349 99.56 Very High Very High Very High
ischemia 48 99.48 Very High Very High Very High
antagonist 4 97.32 Very High Very High Very High
intrathecal 41 97.00 Very High Very High Very High
cytokine 36 96.12 Very High Very High Very High
fibrosis 9 95.24 Very High Very High Very High
agonist 6 94.92 High High
Disease Link Frequency Relevance Heat
Multiple Sclerosis 632 100.00 Very High Very High Very High
Hemorrhagic Shock 35 100.00 Very High Very High Very High
Pressure And Volume Under Development 33 100.00 Very High Very High Very High
Shock 17 100.00 Very High Very High Very High
Hemorrhage 14 100.00 Very High Very High Very High
Neuropathic Pain 7 99.98 Very High Very High Very High
Cv Unclassified Under Development 41 99.48 Very High Very High Very High
Disease 118 99.00 Very High Very High Very High
Cv General 4 Under Development 7 98.96 Very High Very High Very High
Hypoxia 17 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that G-CSF production specific for the hemorrhage component of shock is dependent on resuscitation.
Positive_regulation (dependent) of Gene_expression (production) of G-CSF associated with shock and cva
1) Confidence 0.67 Published 1997 Journal Arch Orthop Trauma Surg Section Abstract Doc Link 9061173 Disease Relevance 1.04 Pain Relevance 0.28
We have recently reported that in the lung and the liver of rats resuscitated after hemorrhagic shock (HS) G-CSF mRNA expression is induced.
Positive_regulation (induced) of Gene_expression (expression) of G-CSF mRNA in liver associated with hemorrhagic shock
2) Confidence 0.67 Published 1997 Journal Arch Orthop Trauma Surg Section Abstract Doc Link 9061173 Disease Relevance 0.65 Pain Relevance 0.22
The present study was designed to test the hypothesis that the upregulation of G-CSF mRNA expression is the consequence of HS followed by resuscitation and that ischemia alone is insufficient to induce G-CSF mRNA expression in the affected organs.
Positive_regulation (induce) of Gene_expression (expression) of G-CSF mRNA associated with ischemia and hemorrhagic shock
3) Confidence 0.67 Published 1997 Journal Arch Orthop Trauma Surg Section Abstract Doc Link 9061173 Disease Relevance 0.83 Pain Relevance 0.26
The present study was designed to test the hypothesis that the upregulation of G-CSF mRNA expression is the consequence of HS followed by resuscitation and that ischemia alone is insufficient to induce G-CSF mRNA expression in the affected organs.
Positive_regulation (upregulation) of Gene_expression (expression) of G-CSF mRNA associated with ischemia and hemorrhagic shock
4) Confidence 0.67 Published 1997 Journal Arch Orthop Trauma Surg Section Abstract Doc Link 9061173 Disease Relevance 0.76 Pain Relevance 0.25
G-CSF improves functional outcome after cerebral ischemia
Positive_regulation (improves) of Gene_expression (improves) of G-CSF associated with cv general 4 under development and ischemia
5) Confidence 0.50 Published 2006 Journal BMC Biol Section Body Doc Link PMC1633735 Disease Relevance 0.64 Pain Relevance 0.13
Granulocyte colony-stimulating factor (G-CSF) production in hemorrhagic shock requires both the ischemic and resuscitation phase.
Positive_regulation (requires) of Gene_expression (production) of G-CSF in Granulocyte associated with hemorrhagic shock
6) Confidence 0.48 Published 1997 Journal Arch Orthop Trauma Surg Section Title Doc Link 9061173 Disease Relevance 0.69 Pain Relevance 0.23
Since overproduction of CSF is relatively rare, most investigators have focused on CSF malabsorption as the most likely cause of hydrocephalus.
Positive_regulation (overproduction) of Gene_expression (overproduction) of CSF associated with hydrocephalus
7) Confidence 0.47 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2831828 Disease Relevance 0.50 Pain Relevance 0.03
These results suggest that chronic neuropathic pain produces increased CSF levels of secretogogues for chromaffin cells, and illustrates the importance of host microenvironmental factors in determining graft function.
Positive_regulation (increased) of Gene_expression (produces) of CSF in CSF associated with neuropathic pain
8) Confidence 0.46 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10825645 Disease Relevance 0.57 Pain Relevance 0.71
These results suggest that chronic neuropathic pain produces increased CSF levels of secretogogues for chromaffin cells, and illustrates the importance of host microenvironmental factors in determining graft function.
Positive_regulation (increased) of Gene_expression (levels) of CSF in CSF associated with neuropathic pain
9) Confidence 0.46 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10825645 Disease Relevance 0.56 Pain Relevance 0.71
PCNA was increased in the EPO and GM-CSF+ EPO groups, while there was no increase in the GM-CSF group.


Positive_regulation (increased) of Gene_expression (groups) of GM-CSF
10) Confidence 0.46 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2917416 Disease Relevance 0 Pain Relevance 0
Moreover, ethanol fractions potently suppressed the expression of cycloxygenase (COX)-2 and granulocyte-macrophage colony-stimulating factor (GM-CSF), which are stimulated by LPS in RAW264.7 cells.
Positive_regulation (stimulated) of Gene_expression (expression) of GM-CSF in granulocyte
11) Confidence 0.46 Published 2008 Journal Phytother Res Section Abstract Doc Link 18688813 Disease Relevance 0.52 Pain Relevance 0.40
Moreover, ethanol fractions potently suppressed the expression of cycloxygenase (COX)-2 and granulocyte-macrophage colony-stimulating factor (GM-CSF), which are stimulated by LPS in RAW264.7 cells.
Positive_regulation (stimulated) of Gene_expression (expression) of granulocyte-macrophage colony-stimulating factor in granulocyte
12) Confidence 0.46 Published 2008 Journal Phytother Res Section Abstract Doc Link 18688813 Disease Relevance 0.52 Pain Relevance 0.40
Moreover, addition of PD98059, a MAPK kinase inhibitor, significantly suppressed the LPS-induced NF-kappaB nuclear translocation and GM-CSF production, suggesting that the PPF-attenuated GM-CSF production in hepatocytes may be attributed to its suppressive effect on MAPK/ERK signaling pathway.
Spec (may) Positive_regulation (attributed) of Gene_expression (production) of GM-CSF in hepatocytes
13) Confidence 0.45 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18387647 Disease Relevance 0.20 Pain Relevance 0.07
This occurred despite a significant increase in vascular endothelial cell growth factor expression in lung and right ventricle in rats given ANTU alone and even more in rats given ANTU plus G-CSF.
Positive_regulation (increase) of Gene_expression (expression) of G-CSF in endothelial cell
14) Confidence 0.44 Published 2003 Journal J. Appl. Physiol. Section Abstract Doc Link 12524378 Disease Relevance 0.77 Pain Relevance 0.09
Moreover, addition of PD98059, a MAPK kinase inhibitor, significantly suppressed the LPS-induced NF-kappaB nuclear translocation and GM-CSF production, suggesting that the PPF-attenuated GM-CSF production in hepatocytes may be attributed to its suppressive effect on MAPK/ERK signaling pathway.
Positive_regulation (induced) of Gene_expression (production) of GM-CSF in hepatocytes
15) Confidence 0.42 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18387647 Disease Relevance 0.27 Pain Relevance 0.12
However, it is possible that the impediment to lymphatic CSF transport may be a local phenomenon with CSF clearance increasing at other absorption sites to compensate, such that global CSF absorption is relatively unchanged.
Positive_regulation (increasing) of Gene_expression (clearance) of CSF
16) Confidence 0.41 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2831828 Disease Relevance 0.34 Pain Relevance 0.11
The intra-CSF injection of DCs in EAE rats induced an exacerbation of clinical signs and an increased systemic antibody response against MOG.
Positive_regulation (induced) of Gene_expression (injection) of intra-CSF associated with multiple sclerosis
17) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2552991 Disease Relevance 0.40 Pain Relevance 0.30
The collected CSF was transferred to centrifuge tubes and processed in an identical manner to the cyst fluid.


Positive_regulation (transferred) of Gene_expression (transferred) of CSF in tubes associated with cyst
18) Confidence 0.39 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2898803 Disease Relevance 0.67 Pain Relevance 0
Astrocytes and oligodendrocytes can be induced to secrete NGF and NT-3 [13,14], and these cells are the most likely the source of NGF and NT-3 in CSF.
Positive_regulation (induced) of Gene_expression (source) of CSF in oligodendrocytes associated with nerve growth factor
19) Confidence 0.38 Published 2001 Journal BMC Pediatr Section Body Doc Link PMC57003 Disease Relevance 0.64 Pain Relevance 0.80
Seemingly, bulk flow of CSF plus any edema fluid formed within the parenchyma is needed to transport IGF-1 as widely as appears to be the case in the hypoxia-ischemia model [37].
Positive_regulation (transport) of Gene_expression (transport) of CSF in parenchyma associated with pressure and volume under development, hypoxia and ischemia
20) Confidence 0.36 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1190198 Disease Relevance 0.36 Pain Relevance 0.12

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