INT68285

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Context Info
Confidence 0.75
First Reported 1997
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 25.40
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SERPINB3) cytoplasm (SERPINB3)
Anatomy Link Frequency
lung 4
blood 1
liver 1
brain 1
vulva 1
SERPINB3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cerebral cortex 1 81.52 Quite High
alcohol 11 79.32 Quite High
antagonist 3 76.84 Quite High
imagery 13 76.60 Quite High
Pain 9 72.56 Quite High
anesthesia 1 71.36 Quite High
gABA 1 60.00 Quite High
Serotonin 5 55.12 Quite High
Inflammation 8 49.76 Quite Low
Dismenorea 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 615 100.00 Very High Very High Very High
Squamous Cell Carcinoma 551 100.00 Very High Very High Very High
Skin Cancer 170 100.00 Very High Very High Very High
Basal And Squamous Cell Skin Cancer 142 100.00 Very High Very High Very High
Papillomavirus Infection 142 100.00 Very High Very High Very High
Carcinoma 26 100.00 Very High Very High Very High
Staphylococcus Infection 18 99.98 Very High Very High Very High
Diverticulitis 21 99.96 Very High Very High Very High
Small Cell Lung Carcinoma 18 99.64 Very High Very High Very High
Mouth Cancer 187 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite SCC histology, prostate-specific antigen (PSA) and androgen receptor (AR) were also expressed in -20% and -70% of tumor cells, respectively.
Gene_expression (expressed) of SCC associated with cancer and carcinoma
1) Confidence 0.75 Published 2007 Journal Hinyokika Kiyo Section Abstract Doc Link 17628942 Disease Relevance 1.43 Pain Relevance 0.09
The presence of the steroidogenic enzymes cytochrome P450(SCC), aromatase, 5alpha-reductase, 3alpha-hydroxysteroid dehydrogenase, and 17beta-hydroxysteroid dehydrogenase in the human brain has now been firmly established by molecular biological and biochemical studies.
Gene_expression (presence) of SCC in brain
2) Confidence 0.65 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 14993041 Disease Relevance 0 Pain Relevance 0.10
Of these patients 49% had elevated serum levels of SCC or CA 125.
Gene_expression (levels) of SCC
3) Confidence 0.58 Published 1997 Journal Gynecol. Oncol. Section Abstract Doc Link 9062153 Disease Relevance 0.71 Pain Relevance 0.07
In another study by Mullin and co-workers on histological normal surgical specimens from the left part of colon in patients with diverticular disease, SCC dropped initially from 250 to 50 ?
Gene_expression (dropped) of SCC in left part associated with diverticulitis
4) Confidence 0.49 Published 2007 Journal BMC Gastroenterol Section Body Doc Link PMC2064914 Disease Relevance 0.10 Pain Relevance 0
In the present study a case of a metastatic pure SCC of the rectum to the liver is presented.
Gene_expression (presented) of SCC in liver associated with skin cancer
5) Confidence 0.36 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1555584 Disease Relevance 0.71 Pain Relevance 0.07
The authors found temporal changes in the expression of five proteins (serpin B3, serpin B1, annexin A3, collagen ?
Gene_expression (expression) of serpin B3
6) Confidence 0.25 Published 2010 Journal Proteome Sci Section Body Doc Link PMC3016264 Disease Relevance 0.21 Pain Relevance 0.07
Although SCC and adenocarcinoma were the most common pathologies in both male and female groups, the proportion of SCC in female was lower than in male group.
Gene_expression (proportion) of SCC associated with adenocarcinoma and skin cancer
7) Confidence 0.21 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2864212 Disease Relevance 1.00 Pain Relevance 0.04
The proportion of SCC was higher in the age group of over 59 but rare in the young group (< 20 years).
Gene_expression (proportion) of SCC associated with skin cancer
8) Confidence 0.21 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2864212 Disease Relevance 0.94 Pain Relevance 0
The other explanation for a higher cost of male oral cancer patients is the higher proportion of SCC in male patients than in female patients.
Gene_expression (proportion) of SCC associated with mouth cancer and skin cancer
9) Confidence 0.21 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2864212 Disease Relevance 0.89 Pain Relevance 0
Five out of the 17 genes (CRABP2, CRIP2, FOS, JAG1, and MST1R) were among the differentially expressed markers between AD and SCC in the original report publishing the Database 1 [16].
Gene_expression (expressed) of SCC associated with squamous cell carcinoma and adenocarcinoma
10) Confidence 0.11 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2633354 Disease Relevance 1.48 Pain Relevance 0
Despite their differential expression among AD, SCC, and normal lung tissues, the 17-gene signature has no difference in expression in the airway epithelial cells taken from smokers diagnosed with AD or SCC, and most genes had reduced expression in the bronchoscopic specimens from patients with lung cancer, with a few exceptions such as FOS gene (Figure 6).
Gene_expression (expression) of SCC in lung associated with squamous cell carcinoma, adenocarcinoma, lung cancer and nicotine addiction
11) Confidence 0.11 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2633354 Disease Relevance 1.69 Pain Relevance 0
In fact, several genes in the signature were also identified as differentially expressed between AD and SCC previously (for example, genes that are marked with ยง in Table 2).
Gene_expression (expressed) of SCC associated with squamous cell carcinoma and adenocarcinoma
12) Confidence 0.11 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2633354 Disease Relevance 0.83 Pain Relevance 0
Two genes, BMP7 and JAG1, were also among the 23 genes that had 4-fold or greater expression in SCC than in AD reported in a separate paper [29].
Gene_expression (expression) of SCC associated with adenocarcinoma and squamous cell carcinoma
13) Confidence 0.10 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2633354 Disease Relevance 1.54 Pain Relevance 0
However, expression of the 17 core genes does not seem to associate with these factors, suggesting that this gene expression signature might be independent of histologic features of AD and SCC, degree of differentiation, and progression of disease, and might represent fundamental biologies of the subtypes, such as cellular origins.
Gene_expression (expression) of SCC associated with squamous cell carcinoma, adenocarcinoma and disease
14) Confidence 0.10 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2633354 Disease Relevance 1.38 Pain Relevance 0
This paper embarks a genome-scale meta-analysis strategy that has at least three advantages compared to either a direct profiling of miRNAs in lung cancers or a direct identifying differentially expressed mRNAs in AD and SCC.
Gene_expression (expressed) of SCC in lung associated with squamous cell carcinoma, adenocarcinoma and lung cancer
15) Confidence 0.10 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2633354 Disease Relevance 1.34 Pain Relevance 0
Among the 11 datasets, majority of them show that BMP7 is up-regulated and TGFBR2/FOS are down-regulated in both AD and SCC compared to normal lung, whereas between AD and SCC, BMP7 has an opposite expression pattern to TGFBR2/FOS (Figure 5).
Gene_expression (expression) of SCC in lung associated with squamous cell carcinoma and adenocarcinoma
16) Confidence 0.10 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2633354 Disease Relevance 1.09 Pain Relevance 0
Identification of differentially expressed genes marking AD and SCC may prove to be of diagnostic value and help unravel molecular basis of their histogenesis and biologies, and deliver more effective and specific systemic therapy.


Gene_expression (expressed) of SCC associated with squamous cell carcinoma and adenocarcinoma
17) Confidence 0.09 Published 2008 Journal BMC Med Genomics Section Abstract Doc Link PMC2633354 Disease Relevance 0.81 Pain Relevance 0
For the detail why AD and SCC were selected but not small cell lung carcinoma (SCLC) and large cell lung carcinoma (LCLC), see below and Additional file 2 for detail.


Neg (not) Gene_expression (selected) of SCC in lung associated with squamous cell carcinoma, adenocarcinoma, lung cancer, small cell lung carcinoma and small cell lung cancer
18) Confidence 0.09 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2633354 Disease Relevance 0.99 Pain Relevance 0
Mastitis produces an increased SCC in milk and may result in milk carrying more infectivity, since it has been shown that TSE can be transmitted in sheep by transfusion of blood and blood cells [19,20].
Gene_expression (produces) of SCC in blood cells associated with staphylococcus infection
19) Confidence 0.06 Published 2008 Journal BMC Vet Res Section Body Doc Link PMC2374774 Disease Relevance 1.05 Pain Relevance 0
The HPV vaccine is a promising new tool for prevention of this HPV related SCC of the vulva.
Neg (prevention) Gene_expression (prevention) of SCC in vulva associated with papillomavirus infection and basal and squamous cell skin cancer
20) Confidence 0.06 Published 2011 Journal Journal of Skin Cancer Section Abstract Doc Link PMC3003991 Disease Relevance 2.07 Pain Relevance 0

General Comments

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