INT68288

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Context Info
Confidence 0.51
First Reported 1997
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 16.87
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SERPINB3) cytoplasm (SERPINB3)
Anatomy Link Frequency
blood 2
ileum 1
tongue 1
lung 1
blood cells 1
SERPINB3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 3 98.72 Very High Very High Very High
imagery 5 94.40 High High
backache 1 92.40 High High
Pain 10 75.04 Quite High
anesthesia 1 71.96 Quite High
Serotonin 16 46.40 Quite Low
medulla 15 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
pruritus 5 5.00 Very Low Very Low Very Low
sodium channel 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Basal And Squamous Cell Skin Cancer 142 100.00 Very High Very High Very High
Skin Cancer 98 100.00 Very High Very High Very High
Squamous Cell Carcinoma 63 100.00 Very High Very High Very High
Cancer 327 99.80 Very High Very High Very High
Staphylococcus Infection 18 99.74 Very High Very High Very High
Metastasis 70 99.64 Very High Very High Very High
Recurrence 74 99.36 Very High Very High Very High
Disease 141 98.40 Very High Very High Very High
Adenocarcinoma 74 97.48 Very High Very High Very High
Carcinoma 7 97.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite a subsequently progressive increase in SCC and G, reproducible responses could be obtained for more than 6 hrs to theophylline and for up to 4 hrs for 5-HT.
Positive_regulation (increase) of SCC
1) Confidence 0.51 Published 2007 Journal BMC Gastroenterol Section Body Doc Link PMC2064914 Disease Relevance 0.06 Pain Relevance 0
Hence, an increase in the luminal conductance will increase the SCC, while a change in parallel conductances will have no effect on measured transmural SCC.
Positive_regulation (increase) of SCC
2) Confidence 0.51 Published 2007 Journal BMC Gastroenterol Section Body Doc Link PMC2064914 Disease Relevance 0 Pain Relevance 0
In general, SCC-increases in response to stimulators larger than 20 ?
Positive_regulation (increases) of SCC
3) Confidence 0.51 Published 2007 Journal BMC Gastroenterol Section Body Doc Link PMC2064914 Disease Relevance 0 Pain Relevance 0
Of these patients 49% had elevated serum levels of SCC or CA 125.
Positive_regulation (elevated) of SCC
4) Confidence 0.45 Published 1997 Journal Gynecol. Oncol. Section Abstract Doc Link 9062153 Disease Relevance 0.71 Pain Relevance 0.07
Blood examination revealed an elevated level of serum SCC antigen.
Positive_regulation (elevated) of SCC in Blood associated with skin cancer
5) Confidence 0.45 Published 2010 Journal J. UOEH Section Abstract Doc Link 20549904 Disease Relevance 1.21 Pain Relevance 0.26
This is somewhat surprising, but partially in agreement with a Ussing chamber study on human ileum, where transmucosal glucose fluxes were stable for 4 hrs despite progressive changes in SCC plus signs of epithelial histological changes after only 2 hrs [21].
Positive_regulation (changes) of SCC in ileum
6) Confidence 0.37 Published 2007 Journal BMC Gastroenterol Section Body Doc Link PMC2064914 Disease Relevance 0.08 Pain Relevance 0
Immunochemistry is helpful in diagnosing SCC using several markers (cytokeratins AE1/AE3, 34BE12, CK5, involucrin, etc) in order to differentiate it from other small cell undifferentiated tumors [20].
Positive_regulation (diagnosing) of SCC associated with cancer and skin cancer
7) Confidence 0.30 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1555584 Disease Relevance 2.03 Pain Relevance 0.08
In his study the SCC Ag was elevated at the time of recurrence and showed a partial response to combination chemotherapy, with a decrease in the serum level.
Positive_regulation (elevated) of SCC associated with skin cancer and recurrence
8) Confidence 0.28 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1555584 Disease Relevance 1.61 Pain Relevance 0
Six of these 17 genes have increased expression in all SCC, while 9 genes have higher expression in at least a subset of AD than in normal lung (Figure 2D).
Positive_regulation (increased) of SCC in lung associated with adenocarcinoma and squamous cell carcinoma
9) Confidence 0.10 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2633354 Disease Relevance 1.40 Pain Relevance 0
Mastitis produces an increased SCC in milk and may result in milk carrying more infectivity, since it has been shown that TSE can be transmitted in sheep by transfusion of blood and blood cells [19,20].
Positive_regulation (increased) of SCC in blood cells associated with staphylococcus infection
10) Confidence 0.06 Published 2008 Journal BMC Vet Res Section Body Doc Link PMC2374774 Disease Relevance 1.04 Pain Relevance 0
The SCC is also dependent on the stage of lactation and the time of milk collection [26].
Positive_regulation (dependent) of SCC
11) Confidence 0.04 Published 2008 Journal BMC Vet Res Section Body Doc Link PMC2374774 Disease Relevance 0.51 Pain Relevance 0
Somatic mutation of PTEN was also demonstrated in some cases of vulvar SCC and VIN, suggesting that PTEN mutation possibly played a role early in the carcinogenesis of vulvar SCC [37].
Positive_regulation (demonstrated) of SCC associated with cancer and basal and squamous cell skin cancer
12) Confidence 0.04 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC3003991 Disease Relevance 2.54 Pain Relevance 0
Somatic mutation of PTEN was also demonstrated in some cases of vulvar SCC and VIN, suggesting that PTEN mutation possibly played a role early in the carcinogenesis of vulvar SCC [37].
Positive_regulation (vulvar) of SCC associated with cancer and basal and squamous cell skin cancer
13) Confidence 0.04 Published 2011 Journal Journal of Skin Cancer Section Body Doc Link PMC3003991 Disease Relevance 2.47 Pain Relevance 0
The relationship between thickness of the primary tumour and occurrence of contralateral cervical metastasis were reported to increase by 5% in T1/T2 SCC of the oral tongue [31].
Positive_regulation (increase) of SCC in tongue associated with cancer and metastasis
14) Confidence 0.04 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2882907 Disease Relevance 2.15 Pain Relevance 0
Mastitis produces an increased SCC in milk and may result in milk carrying more infectivity, since it has been shown that TSE can be transmitted in sheep by transfusion of blood and blood cells [19,20].
Positive_regulation (increased) of SCC in blood associated with staphylococcus infection
15) Confidence 0.02 Published 2008 Journal BMC Vet Res Section Body Doc Link PMC2374774 Disease Relevance 1.04 Pain Relevance 0

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