INT68290

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.73
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 32
Total Number 34
Disease Relevance 7.36
Pain Relevance 11.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Accn1) plasma membrane (Accn1)
Anatomy Link Frequency
DRG 5
epithelium 3
nociceptors 3
bladder 2
skin 2
Accn1 (Mus musculus)
Pain Link Frequency Relevance Heat
ASIC 163 100.00 Very High Very High Very High
nociceptor 111 99.96 Very High Very High Very High
c fibre 51 99.60 Very High Very High Very High
Inflammation 165 99.28 Very High Very High Very High
allodynia 1 98.80 Very High Very High Very High
Root ganglion neuron 5 98.60 Very High Very High Very High
Neuropeptide 35 97.92 Very High Very High Very High
Nav1.9 28 95.12 Very High Very High Very High
Hyperalgesia 51 95.04 Very High Very High Very High
hyperexcitability 4 92.80 High High
Disease Link Frequency Relevance Heat
Aids-related Complex 16 99.52 Very High Very High Very High
Nociception 51 99.30 Very High Very High Very High
INFLAMMATION 171 99.28 Very High Very High Very High
Neuropathic Pain 1 98.80 Very High Very High Very High
Ganglion Cysts 227 98.40 Very High Very High Very High
Acidosis 38 97.68 Very High Very High Very High
Targeted Disruption 57 96.16 Very High Very High Very High
Hyperalgesia 68 95.04 Very High Very High Very High
Pain 63 91.60 High High
Nervous System Injury 2 91.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the mucosa, the ASIC1 gene was more highly expressed in male than in female mice, whereas the expression level of ASIC2 in the bladder muscle was higher in female than in male mice.
Gene_expression (expression) of ASIC2 in bladder
1) Confidence 0.73 Published 2009 Journal BJU Int. Section Body Doc Link 19493263 Disease Relevance 0.13 Pain Relevance 0
RESULTS: ASIC1 was the dominant ASIC subunit expressed in bladder epithelium, whereas both ASIC1 and ASIC2 were expressed in bladder smooth muscle.
Gene_expression (expressed) of ASIC2 in epithelium
2) Confidence 0.73 Published 2009 Journal BJU Int. Section Body Doc Link 19493263 Disease Relevance 0.15 Pain Relevance 0
ASIC is expressed in dorsal root ganglia and is also distributed widely throughout the brain.
Gene_expression (expressed) of ASIC in dorsal root ganglia associated with asic
3) Confidence 0.73 Published 1997 Journal Nature Section Abstract Doc Link 9062189 Disease Relevance 0.30 Pain Relevance 0.42
Localization of ASIC expression in DRG was determined with fluorescence in situ hybridization (FISH) and retrograde tracing.
Gene_expression (expression) of ASIC in DRG associated with asic
4) Confidence 0.73 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17177258 Disease Relevance 0 Pain Relevance 0.33
Similarly, FISH of all neurons in thoracolumbar DRG demonstrated that ASIC2 was expressed in the most (40 +/- 1%) neurons, followed by ASIC3 (24 +/- 1%), then ASIC1 (18 +/- 1%).
Gene_expression (expressed) of ASIC2 in DRG
5) Confidence 0.73 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17177258 Disease Relevance 0 Pain Relevance 0.32
We examined the expression of ASIC1, ASIC2, and ASIC3 mRNAs in lumbar dorsal root ganglion neurons before and 24 hours after carrageenan-induced muscle inflammation.
Spec (examined) Gene_expression (expression) of ASIC2 in muscle associated with ganglion cysts, inflammation and root ganglion neuron
6) Confidence 0.72 Published 2010 Journal J Pain Section Abstract Doc Link 20015700 Disease Relevance 0.96 Pain Relevance 0.44
CONCLUSIONS: We conclude that ASIC2 and ASIC3 channels are not directly involved in the development or maintenance of neuropathic pain after spinal nerve ligation.
Gene_expression (channels) of ASIC2 in spinal nerve
7) Confidence 0.65 Published 2010 Journal Anesthesiology Section Body Doc Link 20693874 Disease Relevance 0 Pain Relevance 0
BACKGROUND: Acid-sensing ion channels 2 and 3 (ASIC2 and ASIC3, respectively) have been implicated as putative mechanotransducers.
Gene_expression (respectively) of ASIC2
8) Confidence 0.65 Published 2010 Journal Anesthesiology Section Abstract Doc Link 20693874 Disease Relevance 0.27 Pain Relevance 0.17
RESULTS: ASIC1 was the dominant ASIC subunit expressed in bladder epithelium, whereas both ASIC1 and ASIC2 were expressed in bladder smooth muscle.
Gene_expression (expressed) of ASIC in epithelium
9) Confidence 0.64 Published 2009 Journal BJU Int. Section Body Doc Link 19493263 Disease Relevance 0.15 Pain Relevance 0
CONCLUSION: The expression of ASIC subunit in the bladder was abundant and showed significant sex differences.
Gene_expression (expression) of ASIC in bladder
10) Confidence 0.64 Published 2009 Journal BJU Int. Section Body Doc Link 19493263 Disease Relevance 0 Pain Relevance 0
The gene expressions of ASIC subunits, TRPV1, TRPA1 and TRPM8 were quantified using real-time reverse transcriptase-polymerase chain reaction.
Gene_expression (expressions) of ASIC
11) Confidence 0.64 Published 2009 Journal BJU Int. Section Body Doc Link 19493263 Disease Relevance 0.18 Pain Relevance 0
Heterologous expression of ASIC induces an amiloride-sensitive cation (Na+ > Ca2+ > K+) channel which is transiently activated by rapid extracellular acidification.
Gene_expression (expression) of ASIC associated with asic
12) Confidence 0.64 Published 1997 Journal Nature Section Abstract Doc Link 9062189 Disease Relevance 0.34 Pain Relevance 0.43
ASIC is expressed in dorsal root ganglia and is also distributed widely throughout the brain.
Gene_expression (expressed) of ASIC in dorsal root ganglia associated with asic
13) Confidence 0.63 Published 1997 Journal Nature Section Abstract Doc Link 9062189 Disease Relevance 0.30 Pain Relevance 0.42
We found that neuropeptide FF (Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe amide) and FMRFamide (Phe-Met-Arg-Phe amide) generated no current on their own but potentiated H+-gated currents from cultured sensory neurons and heterologously expressed ASIC and DRASIC channels.
Gene_expression (expressed) of ASIC in sensory neurons associated with neuropeptide and asic
14) Confidence 0.60 Published 2000 Journal Neuron Section Abstract Doc Link 10798398 Disease Relevance 0.43 Pain Relevance 0.45
In addition, the mechanical thresholds of C fibre units decrease and ASIC2 expression is increased at the RNA and protein levels.
Gene_expression (expression) of ASIC2 associated with c fibre
15) Confidence 0.58 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.39
For ASIC2 expression, a strong effect of GDNF overexpression in vivo is observed and correlates with alterations in mechanical sensitivity of C fibres.
Gene_expression (expression) of ASIC2 associated with c fibre
16) Confidence 0.58 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.31
Conversely, gastroesophageal afferents are less sensitive to benzamil, and its action depends less on ASIC expression. mRNA for ASIC3 showed higher and ASIC1a showed lower relative expression in colonic afferents from thoracolumbar dorsal root ganglia than in gastric afferents from nodose (vagal) ganglia.
Gene_expression (expression) of ASIC in ganglia associated with asic
17) Confidence 0.58 Published 2007 Journal Pain Section Abstract Doc Link 17467171 Disease Relevance 0.06 Pain Relevance 0.31
RESULTS: ASIC1 was the dominant ASIC subunit expressed in bladder epithelium, whereas both ASIC1 and ASIC2 were expressed in bladder smooth muscle.
Gene_expression (expressed) of ASIC in epithelium
18) Confidence 0.56 Published 2009 Journal BJU Int. Section Body Doc Link 19493263 Disease Relevance 0.15 Pain Relevance 0
ASIC2 and ASIC3 are functionally expressed in cochlear spiral ganglia[17], [23].
Gene_expression (expressed) of ASIC2 in ganglia
19) Confidence 0.54 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714966 Disease Relevance 0.17 Pain Relevance 0
In contrast to whole DRG, FISH of colonic neurons showed ASIC3 expression in 73 +/- 2%, ASIC2 in 47 +/- 0.5%, and ASIC1 in 30 +/- 2%.
Gene_expression (expression) of ASIC2 in DRG
20) Confidence 0.49 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17177258 Disease Relevance 0 Pain Relevance 0.41

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox