INT68297

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Context Info
Confidence 0.47
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 4.45
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPT) cell death (MAPT) plasma membrane (MAPT)
cytoskeleton (MAPT) enzyme binding (MAPT) cytoplasm (MAPT)
Anatomy Link Frequency
neuronal 2
tubule 1
MAPT (Homo sapiens)
Pain Link Frequency Relevance Heat
glial activation 2 99.88 Very High Very High Very High
Neurotransmitter 7 91.32 High High
Acute pain 2 87.36 High High
Pain 4 84.00 Quite High
cINOD 3 80.72 Quite High
Hippocampus 59 79.40 Quite High
Potency 2 50.00 Quite Low
anticonvulsant 1 37.68 Quite Low
Central nervous system 30 18.00 Low Low
Inflammation 62 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 234 100.00 Very High Very High Very High
Disease 314 99.90 Very High Very High Very High
Stress 23 99.48 Very High Very High Very High
Death 43 98.48 Very High Very High Very High
Targeted Disruption 214 97.04 Very High Very High Very High
Aging 24 93.00 High High
Shock 6 91.44 High High
Pain 6 87.36 High High
Tauopathy 82 80.48 Quite High
INFLAMMATION 69 80.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Instead, the hyperphosphorylated Tau proteins bind to each other and tie themselves into “knots” known as NFTs [36].
Tau Binding (bind) of
1) Confidence 0.47 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.45 Pain Relevance 0.11
These two approaches may lead to the discovery of site-specific inhibitors for tau and cdk5 interactions rather than competitive inhibitors for ATP binding.
tau Binding (interactions) of
2) Confidence 0.47 Published 2007 Journal Current Alzheimer research Section Abstract Doc Link 18220519 Disease Relevance 0.32 Pain Relevance 0.14
However, in AD the Tau proteins become hyperphosphorylated and lose the ability to bind to microtubules.
Tau Binding (bind) of associated with disease
3) Confidence 0.36 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.49 Pain Relevance 0.12
We are working to discover specific inhibitors that might disrupt the interaction of tau and cdk5 at sites other than the ATP binding site.
tau Spec (might) Binding (interaction) of
4) Confidence 0.36 Published 2007 Journal Current Alzheimer research Section Abstract Doc Link 18220519 Disease Relevance 0.40 Pain Relevance 0.17
METHODS: We determined the induction potency and emergence time for isoflurane, halothane, and sevoflurane using the minimum alveolar anesthetic concentration for loss of righting reflex as an end point in 12- to 14-mo-old triple transgenic Alzheimer (3xTgAD) mice and wild type C57BL6 controls. 3xTgAD mice model AD by harboring three distinct mutations: the APP(Swe), Tau, and PS1 human transgenes, each of which has been associated with familial forms of human AD.
Tau Binding (associated) of
5) Confidence 0.36 Published 2010 Journal Anesth. Analg. Section Body Doc Link 19820240 Disease Relevance 0.08 Pain Relevance 0
Tau is a phosphoprotein that belongs to the family of the microtubule-associated proteins; it binds to tubulin and facilitates tubule polymerization [61].
Tau Binding (binds) of in tubule
6) Confidence 0.36 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.29 Pain Relevance 0
The alternative explanation, i.e. that wild-type and mutant full-length Tau but not truncated Tau255 interact with cellular proteins other than microtubuli, remains open for experimental verification.
Tau Binding (interact) of
7) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748684 Disease Relevance 0.24 Pain Relevance 0
The alternative explanation, i.e. that wild-type and mutant full-length Tau but not truncated Tau255 interact with cellular proteins other than microtubuli, remains open for experimental verification.
Tau Binding (interact) of
8) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748684 Disease Relevance 0.24 Pain Relevance 0
Increased AGE levels explain many of the neuropathological and biochemical features of AD such as extensive protein crosslinking (beta-amyloid and MAP-tau), oxidative stress and neuronal cell death.
tau Binding (crosslinking) of in neuronal associated with stress, alzheimer's dementia, disease and death
9) Confidence 0.35 Published 1997 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 9063589 Disease Relevance 1.01 Pain Relevance 0.08
Increased AGE levels explain many of the neuropathological and biochemical features of AD such as extensive protein crosslinking (beta-amyloid and MAP-tau), glial activation, oxidative stress and neuronal cell death.
tau Binding (crosslinking) of in neuronal associated with stress, alzheimer's dementia, disease, death and glial activation
10) Confidence 0.35 Published 2002 Journal J. Neural Transm. Suppl. Section Abstract Doc Link 12456073 Disease Relevance 0.92 Pain Relevance 0.13
Mutations in tau gene associated with FTDP-17 fall into two broad mechanistic groups.
FTDP-17 Binding (associated) of
11) Confidence 0.30 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1563447 Disease Relevance 0 Pain Relevance 0

General Comments

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