INT68299

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Context Info
Confidence 0.39
First Reported 1996
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 18
Disease Relevance 12.55
Pain Relevance 7.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Tnf) signal transduction (Tnf) extracellular space (Tnf)
extracellular region (Tnf) plasma membrane (Tnf) intracellular (Tnf)
Anatomy Link Frequency
synovial fluid 1
macrophages 1
monocyte 1
cartilage 1
nucleus 1
Tnf (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 137 100.00 Very High Very High Very High
rheumatoid arthritis 90 100.00 Very High Very High Very High
antagonist 6 100.00 Very High Very High Very High
Paracetamol 9 99.36 Very High Very High Very High
Infliximab 19 99.20 Very High Very High Very High
spinal inflammation 10 99.16 Very High Very High Very High
allodynia 2 98.80 Very High Very High Very High
Inflammation 54 98.32 Very High Very High Very High
Thermal hyperalgesia 1 97.80 Very High Very High Very High
chemokine 16 97.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 93 100.00 Very High Very High Very High
Necrosis 11 100.00 Very High Very High Very High
Cancer 11 100.00 Very High Very High Very High
Low Back Pain 11 99.16 Very High Very High Very High
Neuropathic Pain 5 98.80 Very High Very High Very High
Injury 9 98.60 Very High Very High Very High
INFLAMMATION 82 98.32 Very High Very High Very High
Hyperalgesia 3 97.80 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 2 97.72 Very High Very High Very High
Toxicity 12 97.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previously, we generated an alpha2M derivative (alpha(2)-macroglobulin activated for cytokine binding; MAC) similar in structure to alpha(2)M conformational intermediates, which binds tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and inhibits endotoxin toxicity.
tumor necrosis factor-alpha Binding (binds) of associated with toxicity, necrosis, cancer and cytokine
1) Confidence 0.39 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17725582 Disease Relevance 1.18 Pain Relevance 0.55
Lipopolysaccharide induced protection against sulfur mustard cytotoxicity in RAW264.7 cells through generation of TNF-alpha.
TNF-alpha Binding (generation) of
2) Confidence 0.37 Published 2010 Journal J Toxicol Sci Section Title Doc Link 20519843 Disease Relevance 0.41 Pain Relevance 0.26
Infliximab is a chimeric monoclonal antibody that binds to tumour necrosis factor-alpha (TNFalpha) and neutralises its effects.
TNFalpha Binding (binds) of associated with necrosis, infliximab and cancer
3) Confidence 0.36 Published 2002 Journal BioDrugs Section Abstract Doc Link 11985485 Disease Relevance 0.72 Pain Relevance 0.40
It binds to TNFalpha and blocks its biological activity.
TNFalpha Binding (binds) of
4) Confidence 0.36 Published 2004 Journal BioDrugs Section Abstract Doc Link 15161337 Disease Relevance 0.75 Pain Relevance 0.59
Two serious adverse events occurred, namely, acute bacterial pneumonia and recurrent impetigo; in both cases the outcome was promptly favorable after a brief interruption of the TNFalpha antagonist.
TNFalpha Binding (interruption) of
5) Confidence 0.36 Published 2009 Journal Joint Bone Spine Section Body Doc Link 19070529 Disease Relevance 0 Pain Relevance 0
It has also been reported that LIF is found in high concentrations in cartilage and synovial fluid of patients with RA.16 IL-1 and TNF-?
TNF Binding (concentrations) of in synovial fluid associated with rheumatoid arthritis
6) Confidence 0.36 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017685 Disease Relevance 1.27 Pain Relevance 0.82
[Current therapy with TNFalpha blocking agents for ankylosing spondylitis and undifferentiated spondyloarthritis].
TNFalpha Binding (therapy) of associated with spinal inflammation
7) Confidence 0.36 Published 2004 Journal Z Rheumatol Section Title Doc Link 15224223 Disease Relevance 0.71 Pain Relevance 0.54
Infliximab is a chimeric human-murine monoclonal antibody of the IgG1 type with a high affinity and specificity for tumor necrosis factor alpha (TNFalpha).
tumor necrosis factor Binding (specificity) of associated with necrosis, infliximab and cancer
8) Confidence 0.35 Published 2005 Journal J Fr Ophtalmol Section Abstract Doc Link 15851955 Disease Relevance 1.09 Pain Relevance 0.40
OBJECTIVES: To develop recommendations for TNFalpha antagonist therapy in patients with spondyloarthropathies.
TNFalpha Binding (recommendations) of associated with antagonist
9) Confidence 0.34 Published 2006 Journal Joint Bone Spine Section Abstract Doc Link 16843030 Disease Relevance 0.15 Pain Relevance 0.20
Furthermore, Cardiospermum halicacabum L. ethanol extract inhibited the TNF-alpha induced DNA binding activity of NF-kappaB, which was associated with decreased p65 protein level in the nucleus in Jurkat cells.
TNF-alpha Binding (binding) of in nucleus
10) Confidence 0.32 Published 2009 Journal J Ethnopharmacol Section Body Doc Link 19393729 Disease Relevance 0.06 Pain Relevance 0
Furthermore, immunoreactivity for the proinflammatory cytokine tumor necrosis factor-alpha (TNF) was reduced in mice treated with the highest dose of anti-IL-1RI.
tumor necrosis factor-alpha Binding (immunoreactivity) of associated with necrosis, cancer and cytokine
11) Confidence 0.30 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10454137 Disease Relevance 1.07 Pain Relevance 0.80
Previously, we generated an alpha2M derivative (alpha(2)-macroglobulin activated for cytokine binding; MAC) similar in structure to alpha(2)M conformational intermediates, which binds tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and inhibits endotoxin toxicity.
TNF-alpha Binding (binds) of associated with toxicity, necrosis, cancer and cytokine
12) Confidence 0.30 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17725582 Disease Relevance 1.18 Pain Relevance 0.55
In part they appear to mediate their effects due to their ability to suppress the release of cytokines such as TNF alpha and IL-1 from macrophages, as well as the binding of these cytokines to high-affinity receptors on target cells involved in the inflammation process.
TNF alpha Binding (binding) of in macrophages associated with inflammation and cytokine
13) Confidence 0.29 Published 1996 Journal Int J Tissue React Section Abstract Doc Link 9063766 Disease Relevance 0.45 Pain Relevance 0.32
Treatment of mice with the protein before administration of acetaminophen also reduced serum nitrite and TNF-alpha formation.
TNF-alpha Binding (formation) of associated with paracetamol
14) Confidence 0.24 Published 2009 Journal Chem. Biol. Interact. Section Abstract Doc Link 18835260 Disease Relevance 0.44 Pain Relevance 0.62
Interleukin-8 (IL-8/KC), monocyte chemotactic protein-1 (MCP-1) and tumor necrosis factor alpha (TNF-?)
tumor necrosis factor alpha Binding (Interleukin-8) of in monocyte associated with necrosis and cancer
15) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2756629 Disease Relevance 1.33 Pain Relevance 0.43
It has also been reported that LIF is found in high concentrations in cartilage and synovial fluid of patients with RA.16 IL-1 and TNF-?
TNF Binding (concentrations) of in cartilage associated with rheumatoid arthritis
16) Confidence 0.12 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017685 Disease Relevance 1.27 Pain Relevance 0.82
Only CRP and TNFalpha were significantly associated with UBMA scores in an ordinal logistic regression analysis in which age and BMI (body mass index) were covariates.
TNFalpha Binding (associated) of in body associated with obesity
17) Confidence 0.05 Published 2007 Journal Clin. Sci. Section Abstract Doc Link 17064252 Disease Relevance 0.47 Pain Relevance 0.19
The E. coli XerC and XerD proteins convert dimeric chromosomes to monomers before cell division by acting in a complex with the cell septation protein FtsK on dif site DNA: XerD forms Holliday junctions using one strand of the interacting dif sites if it is activated by FtsK protein; and XerC then forms these junctions using the other strand [48].
dif Binding (interacting) of
18) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731543 Disease Relevance 0 Pain Relevance 0

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