INT683

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1978
Last Reported 2011
Negated 5
Speculated 6
Reported most in Abstract
Documents 173
Total Number 181
Disease Relevance 74.55
Pain Relevance 46.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (AVP) cell-cell signaling (AVP) response to stress (AVP)
signal transducer activity (AVP) cytosol (AVP) extracellular space (AVP)
Anatomy Link Frequency
plasma 56
blood 9
heart 7
neurons 5
hypothalamus 4
AVP (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 434 100.00 Very High Very High Very High
noradrenaline 370 100.00 Very High Very High Very High
Dopamine 89 100.00 Very High Very High Very High
depression 44 100.00 Very High Very High Very High
Opioid 32 100.00 Very High Very High Very High
Somatostatin 29 100.00 Very High Very High Very High
Serotonin 29 100.00 Very High Very High Very High
Enkephalin 18 100.00 Very High Very High Very High
Buprenorphine 17 100.00 Very High Very High Very High
substance P 15 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv General 2 Under Development 1015 100.00 Very High Very High Very High
Heart Rate Under Development 418 100.00 Very High Very High Very High
Syndrome 316 100.00 Very High Very High Very High
Natriuresis 135 100.00 Very High Very High Very High
Depression 53 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 323 99.98 Very High Very High Very High
Stress 218 99.98 Very High Very High Very High
Hypoglycemia 27 99.98 Very High Very High Very High
Pressure And Volume Under Development 204 99.96 Very High Very High Very High
Hepatotoxicity 15 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When given alone, naloxone and ethanol did not modify AVP secretion, whereas nicotine increased plasma AVP levels by about 2.5-fold.
Positive_regulation (increased) of AVP in plasma associated with nicotine and narcan
1) Confidence 0.70 Published 1987 Journal Metab. Clin. Exp. Section Abstract Doc Link 3600293 Disease Relevance 0.26 Pain Relevance 0.70
The results suggest either that circulating AVP is taken up and accumulated by the human vas deferens, and/or that AVP is synthesized locally.
Positive_regulation (accumulated) of AVP in vas deferens
2) Confidence 0.70 Published 1988 Journal J. Urol. Section Abstract Doc Link 3172359 Disease Relevance 0 Pain Relevance 0.27
Physical exercise significantly increased the AVP levels.
Positive_regulation (increased) of AVP
3) Confidence 0.70 Published 2010 Journal Regul. Pept. Section Abstract Doc Link 20346989 Disease Relevance 0 Pain Relevance 0.36
This results in a 100-fold increase in AVP mRNA in the BNST and a massive increase in AVP peptide in the BNST and its projections to the lateral septum and lateral habenula.
Positive_regulation (increase) of AVP mRNA
4) Confidence 0.70 Published 1996 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 8818400 Disease Relevance 0.67 Pain Relevance 0.42
Infusions of 0.01–0.04 U/min vasopressin in septic shock patients increase plasma vasopressin concentrations.
Positive_regulation (increase) of vasopressin in plasma associated with cv general 2 under development
5) Confidence 0.70 Published 2005 Journal Crit Care Section Abstract Doc Link PMC1175907 Disease Relevance 0.60 Pain Relevance 0
They found that plasma vasopressin levels are increased at the initial phase of septic shock in almost all cases, which could contribute to the maintenance of arterial blood pressure, and that the levels decreased afterward.
Positive_regulation (increased) of vasopressin in blood associated with cv general 2 under development
6) Confidence 0.70 Published 2005 Journal Crit Care Section Body Doc Link PMC1175907 Disease Relevance 0.71 Pain Relevance 0
Although it has been demonstrated that suppression of the baroreflex increases considerably the vasoconstrictor power of vasopressin, this phenomenon is probably multifactorial [67,97].
Positive_regulation (increases) of vasopressin
7) Confidence 0.70 Published 2005 Journal Crit Care Section Body Doc Link PMC1175907 Disease Relevance 0.76 Pain Relevance 0.06
Surgical stimulation is capable of significantly increasing ADH levels.
Positive_regulation (increasing) of ADH
8) Confidence 0.70 Published 1980 Journal Contemp Anesth Pract Section Abstract Doc Link 7011672 Disease Relevance 0.26 Pain Relevance 0.34
Experiments in rats have shown that osmotic stimuli increase both AVP and prodynorphin in the hypothalamus.
Positive_regulation (increase) of AVP in hypothalamus
9) Confidence 0.69 Published 1990 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1974260 Disease Relevance 0 Pain Relevance 0.30
Naloxone both reduced resting levels of vasopressin and inhibited the rise in vasopressin induced by an orthostatic stimulus.
Positive_regulation (induced) of vasopressin associated with narcan
10) Confidence 0.69 Published 1980 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7358835 Disease Relevance 0 Pain Relevance 0.51
Plasma ADH levels increased postoperatively in all patients, but in patients given NLA followed by postoperative intramuscular narcotics, plasma levels of ADH were more than twice as great as in patients given epidural anesthesia followed by epidural fentanyl.
Positive_regulation (increased) of ADH in plasma associated with anesthesia and epidural
11) Confidence 0.69 Published 1983 Journal Anesth. Analg. Section Abstract Doc Link 6869858 Disease Relevance 0.31 Pain Relevance 0.86
Influence of epidural fentanyl on stress-induced elevation of plasma vasopressin (ADH) after surgery.
Positive_regulation (elevation) of ADH in plasma associated with stress and epidural
12) Confidence 0.69 Published 1983 Journal Anesth. Analg. Section Title Doc Link 6869858 Disease Relevance 0.36 Pain Relevance 0.83
Our findings contrast with previous studies with other anesthetics, including fentanyl, in which plasma levels of ADH and GH become markedly elevated during bypass.
Positive_regulation (elevated) of ADH in plasma
13) Confidence 0.68 Published 1982 Journal Anesth. Analg. Section Abstract Doc Link 6461279 Disease Relevance 0.09 Pain Relevance 0.56
The operation period was accompanied by elevated ADH-levels with a maximum of 500% above initial values. 5 patients having been antagonized postoperatively with naloxone 0.005 mg/kgbw showed marked increase in ADH-level.
Positive_regulation (increase) of ADH associated with narcan
14) Confidence 0.67 Published 1983 Journal Anaesthesist Section Abstract Doc Link 6869765 Disease Relevance 0.09 Pain Relevance 0.18
None of the drugs changed AVP.
Positive_regulation (changed) of AVP
15) Confidence 0.67 Published 2000 Journal Eur. J. Clin. Pharmacol. Section Body Doc Link 11009046 Disease Relevance 0 Pain Relevance 0
Vasopressin (AVP) in plasma was greatly increased (up to 76 pg/ml) in three of the six subjects after the higher dose of meptazinol, but remained on a low level in the other three and after all other drug doses.
Positive_regulation (increased) of AVP in plasma
16) Confidence 0.67 Published 1987 Journal Pharmacol. Toxicol. Section Abstract Doc Link 3438224 Disease Relevance 0.08 Pain Relevance 0.41
There was a small but significant increase in AVP in the placebo group and the 600 mg ibuprofen group, but not in the 1200 mg ibuprofen group.
Positive_regulation (increase) of AVP
17) Confidence 0.67 Published 2001 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 11768323 Disease Relevance 0.06 Pain Relevance 0.12
With respect to time course, earlier and more marked increases of epinephrine, norepinephrine, and antidiuretic hormone (ADH) levels were observed in the isoflurane groups compared to the halothane groups (P less than 0.01), representing the more rapid elimination of isoflurane.
Positive_regulation (increases) of ADH associated with halothane and isoflurane
18) Confidence 0.67 Published 1991 Journal Anaesthesist Section Abstract Doc Link 1952037 Disease Relevance 0.36 Pain Relevance 1.11
In Groups EP-L and IV-F, the plasma antidiuretic hormone (ADH) level increased more than in Group EP-F.
Positive_regulation (increased) of ADH in plasma associated with lidocaine
19) Confidence 0.67 Published 1995 Journal Anesth. Analg. Section Abstract Doc Link 7486099 Disease Relevance 0.09 Pain Relevance 1.36
Compared with control subjects, on admission patients showed increased plasma levels of ANP, as well as increased plasma renin activity (PRA), aldosterone, norepinephrine, epinephrine, dopamine, and antidiuretic hormone (ADH).
Positive_regulation (increased) of ADH in plasma associated with dopamine
20) Confidence 0.67 Published 1991 Journal Eur. Heart J. Section Abstract Doc Link 1829681 Disease Relevance 0.79 Pain Relevance 0.21

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox