INT6830

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Context Info
Confidence 0.55
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 7.91
Pain Relevance 1.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Notch1) Golgi apparatus (Notch1) plasma membrane (Notch1)
nucleus (Notch1) embryo development (Notch1) cytoplasm (Notch1)
Anatomy Link Frequency
Notch 8
dendrites 1
astrocyte 1
Notch1 (Mus musculus)
Pain Link Frequency Relevance Heat
Demyelination 6 99.92 Very High Very High Very High
tail-flick 1 98.72 Very High Very High Very High
opioid receptor 2 98.60 Very High Very High Very High
Central nervous system 24 97.08 Very High Very High Very High
analgesia 2 95.12 Very High Very High Very High
Morphine 2 94.40 High High
COX2 4 87.96 High High
cytokine 55 86.44 High High
Antinociceptive 1 85.64 High High
narcan 3 77.56 Quite High
Disease Link Frequency Relevance Heat
Demyelinating Disease 7 99.92 Very High Very High Very High
Stress 65 99.76 Very High Very High Very High
Cancer 291 99.44 Very High Very High Very High
Genetic Translocation 1 99.42 Very High Very High Very High
Infection 37 99.06 Very High Very High Very High
Epstein-barr Virus 64 98.86 Very High Very High Very High
Creutzfeldt Jakob Disease 288 98.80 Very High Very High Very High
Papillomavirus Infection 76 98.72 Very High Very High Very High
Congenital Anomalies 6 95.00 High High
Disease 286 93.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot for activated Notch1
Positive_regulation (activated) of Notch1
1) Confidence 0.55 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2841166 Disease Relevance 0.05 Pain Relevance 0.06
Based upon these studies, USC-HN1 demonstrated an increased level of activated Notch1 protein at levels equal to or higher than the Karpas 299 positive control (Figure 9).


Positive_regulation (activated) of Notch1
2) Confidence 0.55 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2841166 Disease Relevance 0.72 Pain Relevance 0.11
Based upon these studies, USC-HN1 demonstrated an increased level of activated Notch1 protein at levels equal to or higher than the Karpas 299 positive control (Figure 9).


Positive_regulation (increased) of Notch1
3) Confidence 0.55 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2841166 Disease Relevance 0.78 Pain Relevance 0.11
In the regulation of the nicotinic acetylcholine receptor gene, Gabpa recruits the histone acetyl transferase p300 when the promoter is activated, and recruits the histone deacetylase HDAC1 when the promoter is not activated [35].
Positive_regulation (activated) of p300
4) Confidence 0.49 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.08 Pain Relevance 0
In this scenario, without periostin, Notch1 precursor can not be well folded under the stress condition, causing the insufficient S1-cleaved heterodimeric Notch1 that is probably easily degraded, resulting in reduction of the N1™ level.
Positive_regulation (causing) of Notch1 associated with stress
5) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0.63 Pain Relevance 0
This result supports the periostin function for maintenance of Notch1 protein shown in Fig. 3A, suggesting that periostin maintains both Notch1 protein expression and subsequent signaling under the stress condition.
Positive_regulation (maintenance) of Notch1 protein associated with stress
6) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0.50 Pain Relevance 0
Activation of Notch-1 and Notch-3 in embryonic progenitors promotes radial glial fate and astrocyte fate postnatally (Gaiano et al., 2000).
Positive_regulation (Activation) of Notch-1 in astrocyte
7) Confidence 0.44 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 0.36 Pain Relevance 0.05
Viral screening revealed no HPV or EBV infection, while western blotting displayed significant upregulation of activated, cleaved Notch1.


Positive_regulation (upregulation) of Notch1 associated with papillomavirus infection, epstein-barr virus and infection
8) Confidence 0.37 Published 2010 Journal Head Neck Oncol Section Abstract Doc Link PMC2841166 Disease Relevance 0.67 Pain Relevance 0.04
Although the SH group of TAN were required for the covalent interaction with opioid receptors, the site of TAN's interaction appears to involve other than protein SH groups.
Positive_regulation (required) of TAN associated with opioid receptor
9) Confidence 0.31 Published 1992 Journal Neurochem. Res. Section Abstract Doc Link 1334238 Disease Relevance 0 Pain Relevance 0.66
These include chromosomal translocations, gain-of-function mutations activating NOTCH1, deletion of tumour suppressor gene CDKN2A, 6q interstitial losses, and SIL-TAL1 rearrangement [196,198].
Positive_regulation (activating) of NOTCH1 associated with cancer and genetic translocation
10) Confidence 0.30 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.77 Pain Relevance 0
Third, genotypic expression of B2A1 cells as seen with RT-PCR analysis demonstrates mRNA for nestin, Notch1, and PDGFR-?
Positive_regulation (demonstrates) of Notch1
11) Confidence 0.26 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2826742 Disease Relevance 0.17 Pain Relevance 0.09
Another transcription regulator, c-Jun, is similarly elevated in the Schwann cells of injured nerves, and as with Notch 1, demyelination is delayed when this elevation is prevented [12]. c-Jun is also required for the generation of the characteristic molecular and morphological phenotype of the dedifferentiated cell [28].
Positive_regulation (elevated) of Notch 1 in Notch associated with demyelination
12) Confidence 0.14 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948355 Disease Relevance 0.52 Pain Relevance 0.23
Activation of Notch-1 stimulates the HES and HERP families of inhibitor effecter proteins [38], which in turn inhibit pro-neuronal genes that maintain the length and branching of dendrites.
Positive_regulation (Activation) of Notch-1 in dendrites
13) Confidence 0.14 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2825502 Disease Relevance 0.24 Pain Relevance 0.09
Nicastrin carries the truncated Notch-1 into the ?
Positive_regulation (truncated) of Notch-1 in Notch
14) Confidence 0.14 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2825502 Disease Relevance 0.32 Pain Relevance 0.07
This information is a prerequisite to the second half of this review in which we present evidence that rPrPSc accumulation in synaptic regions links Notch-1 signaling with the dendritic degeneration.
Positive_regulation (links) of Notch-1 in Notch
15) Confidence 0.14 Published 2010 Journal Mol Neurodegener Section Abstract Doc Link PMC2825502 Disease Relevance 0.60 Pain Relevance 0
Nicastrin, the molecule that transports truncated Notch-1 to the ?
Positive_regulation (transports) of Notch-1 in Notch
16) Confidence 0.14 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2825502 Disease Relevance 0.20 Pain Relevance 0
Nicastrin transports the truncated Notch-1 to the ?
Positive_regulation (truncated) of Notch-1 in Notch
17) Confidence 0.14 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2825502 Disease Relevance 0.34 Pain Relevance 0
The truncated Notch-1 is a specific ligand for Nicastrin, which is 1 of the 4 proteins that comprise ?
Positive_regulation (truncated) of Notch-1 in Notch
18) Confidence 0.14 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2825502 Disease Relevance 0.27 Pain Relevance 0.07
This suggests that between 60 and 100 days truncated Notch-1 was being formed at a faster rate than Nicastrin could transport it to ?
Positive_regulation (formed) of Notch-1 in Notch
19) Confidence 0.14 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2825502 Disease Relevance 0.13 Pain Relevance 0
PrPSc accumulation in neuronal plasma membranes links Notch-1 activation to dendritic degeneration in prion diseases

Prion diseases are disorders of protein conformation in which PrPC, the normal cellular conformer, is converted to an abnormal, protease-resistant conformer rPrPSc.

Positive_regulation (activation) of Notch-1 in Notch associated with creutzfeldt jakob disease
20) Confidence 0.13 Published 2010 Journal Mol Neurodegener Section Title Doc Link PMC2825502 Disease Relevance 0.55 Pain Relevance 0

General Comments

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